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Head-to-head comparison – definition written & reviewed by Australian experts Head-to-head comparison

A direct comparison in a clinical trial between two or more medicines.

Direct comparisons provide more reliable information about how two medicines compare. Such trials don’t always happen before a medicine is approved and made available — at this point, many medicines have been compared with placebo, but not with other medicines.

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Date published: 2011-01-24 00:00:00

Reasonable care is taken to provide accurate information at the date of creation. This information is not intended as a substitute for medical advice from a qualified health professional. Health professionals should rely on their own expertise and enquiries. Where permitted by law, NPS disclaims all liability (including for negligence) for any loss, damage or injury resulting from reliance on or use of this information. Read our full disclaimer.

References to brands should not be taken as an endorsement by NPS.