Antidepressants and driving

Some antidepressants make you drowsy, dizzy or less alert, and if you’re affected this way, it can make driving or operating machinery unsafe. Wait to see how the medicine affects you before you drive or use machinery.

Tricyclic antidepressants (TCAs), mianserin and mirtazapine are more likely to affect your ability to drive than are selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs). See Types of antidepressants for the individual medicines in these groups.

Antidepressants that cause drowsiness are best taken at night — ask your doctor or pharmacist for information about your medicine, or check the consumer medicine information (CMI) for your medicine.

Read more about medicines, machinery and driving.

For more information

  • Psychotropic Expert Group. Therapeutic Guidelines: Psychotropic, Version 6. In: eTG complete. Melbourne: Therapeutic Guidelines Limited; 2008. (Accessed 9 February 2012).
  • Rossi S, ed. eAMH [online]. Adelaide: Australian Medicines Handbook, 2012. (Accessed 9 February 2012).