Types of antidepressants

Antidepressants can be grouped according to how they work. The different types are:

The individual medicines and types are shown in the table below. Follow the links to the active ingredient to find brand names and see the consumer medicine information (CMI).

The different types of antidepressants are about as effective as each other, but the type and severity of side effects can be quite different between them and between individual medicines of the same type. See How do the side effects of different antidepressants compare?

Types of antidepressants

Antidepressant typeActive ingredient
SSRIs (selective serotonin reuptake inhibitors)Citalopram
Escitalopram
Fluoxetine
Fluvoxamine
Paroxetine
Sertraline
SNRIs (serotonin and noradrenaline reuptake inhibitors)Duloxetine
Venlafaxine
Desvenlafaxine
Noradrenaline reuptake inhibitorReboxetine
TCAs (tricyclic antidepressants)Amitriptyline
Nortriptyline
Clomipramine
Dothiepin
Doxepin
Imipramine
Trimipramine*
RIMA (reversible inhibitor of monoamine oxidase A)Moclobemide
Tetracyclic antidepressantMianserin
Tetracyclic analogue of mianserin (sometimes called noradrenergic and specific serotonergic antidepressant [NaSSA])Mirtazapine
MAOIs (monoamine oxidase inhibitors)Phenelzine
Tranylcypromine
Melatonergic antidepressantAgomelatine*

*Not available on the PBS

References