Phenergan Injection

Phenergan Injection is a brand of medicine containing the active ingredient promethazine (antihistamine medicines).

Find out more about active ingredients.

Consumer medicine information (CMI) leaflet

Developed by the pharmaceutical company responsible for this medicine in Australia, according to TGA regulations.

Phenergan Injection®

Promethazine hydrochloride


Consumer Medicine Information

What is in this leaflet

This leaflet answers some common questions about Phenergan Injection.

It does not contain all the available information.

It does not take the place of talking to your doctor or pharmacist.

All medicines have risks and benefits. Your doctor has weighed the risks of you being given Phenergan Injection against the benefits this medicine is expected to have for you.

If you have any concerns about being given this medicine, ask your doctor or pharmacist.

Keep this leaflet in a safe place. You may need to read it again.

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What Phenergan Injection is used for

Phenergan Injection is an antihistamine used to treat allergic reactions, and to relieve nausea, vomiting and dizziness. It is also used as a premedication before surgery.

Your doctor may have prescribed Phenergan Injection for another reason.

Ask your doctor if you have any questions about why Phenergan Injection has been prescribed for you.

This medicine is available only with a doctor's prescription.

There is no evidence that Phenergan Injection is addictive.

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Before you are given Phenergan Injection

When you must not be given it

You should not be given Phenergan Injection if you have an allergy to promethazine hydrochloride, other phenothiazine-derivative antihistamines, or any of the ingredients listed at the end of this leaflet.

Some of the symptoms of an allergic reaction may include:

  • asthma
  • swelling of the face, lips, tongue or throat which may cause difficulty in swallowing or breathing
  • skin rashes and itching.

You should not be given Phenergan Injection if you:

  1. are breastfeeding or intend to breastfeed.
Promethazine is excreted in breast milk and therefore should not be used in breastfeeding women
  1. have jaundice
  2. are taking monoamine oxidase inhibitors (MAOIs)
  3. have received high doses of other CNS depressants.

Do not give this medicine to a patient who is unconscious or in a coma.

Do not give this medicine to a newborn or premature infant.

Do not use for children under two years old, due to the potential for fatal respiratory depression.

Do not use if the the packaging is torn or shows signs of tampering.

Do not use after the expiry date (EXP) printed on the pack. If this medicine is used after the expiry date has passed, it may not work as well.

If you are not sure whether you should start treatment with Phenergan Injection, talk to your doctor.

Before you are given it

Tell your doctor if you are allergic to any ingredients listed at the end of this leaflet.

Tell your doctor if you have had any allergic reaction to phenothiazine or antihistamine medicines.

Tell your doctor if you have or have ever had any medical conditions especially the following:

  • cardiovascular disease
  • blood pressure problems
  • liver problems
  • kidney or bladder problems
  • breathing problems
  • glaucoma - an eye condition
  • prostate problems
  • stomach ulcer or blockage
  • epilepsy.

Tell your doctor if you are breastfeeding or planning to breastfeed. Promethazine is excreted in breast milk and therefore should not be used in breastfeeding women.

Tell your doctor if you are pregnant or plan to become pregnant. This medicine is not recommended to be used during pregnancy. Your doctor will discuss the risks and benefits of being given Phenergan Injection if you are pregnant.

Tell your doctor if you plan to have surgery.

If you have not told your doctor about any of the above, tell them before you are given Phenergan Injection.

Use in children

Children are more sensitive to the effects of antihistamines and Phenergan Injection should be administered with caution. Serious side effects, such as convulsions, are more likely to occur in younger patients and would be of greater risk to infants than to older children or adults. Also, nightmares or unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in children.

Children or adolescents who show signs of Reye's syndrome should not be given Phenergan Injection.

Do not give this medicine to a newborn or premature infant.

Do not use for children under two years old, due to the potential for fatal respiratory depression.

Use in the Elderly

The elderly are more sensitive to the effects of antihistamines, one of the major effects being low blood pressure.

The elderly are also more likely to have Central Nervous System (CNS) depressive side effects including confusion.

Taking other medicines

Tell your doctor if you are taking any other medicines, including medicines that you buy without a prescription from your pharmacy, supermarket or health food shop.

Some medicines may increase the sedative effect of Phenergan Injection. These include:

  • sedatives
  • pain relievers
  • other antihistamines
  • antidepressants
  • alcohol.

Your doctor or pharmacist has more information on medicines to be careful with or to avoid while being treated with Phenergan Injection.

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How Phenergan Injection is given

How it is given

Phenergan Injection is given as a deep injection into a large muscle.

Phenergan Injection must only be given by a doctor or a nurse.

Your doctor will decide what dose of Phenergan Injection you will receive and how long you will need treatment for.

This depends on your condition and other factors, such as your weight. Sometimes only a single dose of Phenergan Injection is required for the treatment of certain conditions.

If you receive too much (overdose)

Immediately telephone your doctor, or the Poisons Information Centre (telephone Australia 13 11 26), or go to Accident and Emergency at your nearest hospital, if you think you or anyone else may have been given too much Phenergan Injection. Your doctor will decide what dose of Phenergan Injection you need, and this will be given under close supervision, usually in a hospital setting. The risk of an overdosage in these circumstances is low.

Symptoms of an overdose of Phenergan Injection include unconsciousness, convulsions and hallucinations.

Your doctor or pharmacist has information on how to recognise and treat an overdose. Ask your doctor or pharmacist if you have any concerns.

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While you are being given Phenergan Injection

Things you must do

If you are about to start taking any new medicine, tell your doctor and pharmacist that you are being given Phenergan Injection.

Tell all the doctors, dentists and pharmacists who are treating you that you are being given Phenergan Injection.

If you have eczema or a tendency to rheumatism, Phenergan Injection may cause your skin to be more sensitive to the sun. You should protect your skin from exposure to bright sunlight.

If you plan to have surgery that needs a general anaesthetic, tell your doctor or dentist that you are being given Phenergan Injection.

If you become pregnant while you are being given this medicine, tell your doctor immediately.

Things to be careful of

Be careful driving or operating machinery until you know how Phenergan Injection affects you. Phenergan Injection may cause drowsiness, dizziness or sleepiness in some people and may affect alertness.

Avoid alcohol.

Children and the elderly are especially sensitive to the effects of antihistamines.

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Side Effects

Tell your doctor as soon as possible if you have any problems while being given Phenergan Injection, even if you do not think the problems are connected with the medicine or are not listed in this leaflet. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.

Ask your doctor or pharmacist to answer any questions you may have.

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While being given it

Tell your doctor if you notice any of the following and they worry you:

  • dry mouth
  • stomach upset
  • loss of appetite
  • nausea or vomiting
  • diarrhoea or constipation
  • excessive fatigue
  • restlessness
  • dizziness
  • blurred vision.

These are the more common side effects of Phenergan Injection.

Tell your doctor immediately or go to Accident and Emergency at your nearest hospital if you notice any of the following:

  • fever
  • difficulty breathing
  • irregular heartbeat
  • jaundice - yellow tinge to skin or eyes
  • tremors or convulsions
  • tinnitus - buzzing, hissing, ringing or other persistent noise in the ears
  • bruising.

These may be serious side effects. You may need urgent medical attention. Serious side effects are rare.

Other side effects not listed above may also occur in some patients. Tell your doctor if you notice anything else that is making you feel unwell.

Do not be alarmed by this list of possible side effects. You may not experience any of them.

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After being given Phenergan Injection

Storage

Phenergan Injection will be stored in the pharmacy or in the ward.

The injection is to be kept in a cool dry place where the temperature stays below 25°C.

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Product description

What it looks like

Phenergan Injection is a clear, colourless solution in 1 mL ampoules.

Phenergan Injection is available in packs of 10.

Ingredients

Active Ingredient: Phenergan Injection contains 25 mg/mL of promethazine hydrochloride.

Inactive Ingredients:

  • sodium sulphite
  • sodium metabisulfite
  • water for injections.

Phenergan Injection does not contain gluten, lactose, sucrose, tartrazine or any other azo dyes.

Supplier

Phenergan Injection is supplied in Australia by:

sanofi-aventis australia pty ltd
12-24 Talavera Road
Macquarie Park NSW 2113
Australia

This leaflet was prepared in August 2006.

Australian Register Number

AUST R 27545.

® Registered Trademark

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CMI provided by MIMS Australia, December 2014  

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