Agomelatine interactions

Do not take agomelatine with

  • the antidepressant fluvoxamine
  • the antibiotic ciprofloxacin.

See also

Agomelatine and alcohol

Avoid drinking alcohol while taking agomelatine.

Drinking excessive amounts of alcohol while taking agomelatine can cause a severe liver reaction. Symptoms of a severe liver reaction may include:

  • yellow colouring of the skin or whites of the eyes (jaundice)
  • abnormal bleeding or bruising
  • confusion, loss of consciousness or hallucinations.

Tell your doctor about other medicines you are taking

Always tell your doctor and pharmacist about all other medicines you are taking, including over-the-counter and complementary or alternative medicines, and medicines bought over the counter in a pharmacy, supermarket or other store (eg, paracetamol).

Who can I ask about interactions?

Call the NPS Medicines Line on 1300 MEDICINE (1300 633 424) to get information about your prescription, over-the-counter and complementary medicines (herbal, ‘natural’, vitamins and minerals) from a pharmacist. Your call will be answered by healthdirect Australia.

Find out more about

If you are starting agomelatine, see 10 things you should know about antidepressants.

You can also read more about depression and the options for treating it.

For more information

The consumer medicine information (CMI) for your brand of agomelatine is available from our website or a pharmacist. If you have any concerns about interactions, talk to your health professional. The CMI includes:

  • how to take this medicine
  • what to do if you forget to take it
  • if you take too much (overdose)
  • things you must and must not do while taking this medicine
  • signs of severe reactions and what to do.