Do not take agomelatine with
- the antidepressant fluvoxamine
- the antibiotic ciprofloxacin.
Agomelatine and alcohol
Avoid drinking alcohol while taking agomelatine.
Drinking excessive amounts of alcohol while taking agomelatine can cause a severe liver reaction. Symptoms of a severe liver reaction may include:
- yellow colouring of the skin or whites of the eyes (jaundice)
- abnormal bleeding or bruising
- confusion, loss of consciousness or hallucinations.
Tell your doctor about other medicines you are taking
Always tell your doctor and pharmacist about all other medicines you are taking, including over-the-counter and complementary or alternative medicines, and medicines bought over the counter in a pharmacy, supermarket or other store (eg, paracetamol).
Who can I ask about interactions?
Call the NPS Medicines Line on 1300 MEDICINE (1300 633 424) to get information about your prescription, over-the-counter and complementary medicines (herbal, ‘natural’, vitamins and minerals) from a pharmacist. Your call will be answered by healthdirect Australia.
Find out more about
- What agomelatine does and how effective it is
- Who agomelatine is for and who should be cautious
- Side effects of agomelatine
- Brands of agomelatine
If you are starting agomelatine, see 10 things you should know about antidepressants.
For more information
- Starting, switching and stopping antidepressants
- Managing side effects of antidepressants
- Psychological therapies
The consumer medicine information (CMI) for your brand of agomelatine is available from our website or a pharmacist. If you have any concerns about interactions, talk to your health professional. The CMI includes:
- how to take this medicine
- what to do if you forget to take it
- if you take too much (overdose)
- things you must and must not do while taking this medicine
- signs of severe reactions and what to do.
- Rossi S, ed. eAMH [online]. Adelaide: Australian Medicines Handbook, 2012. www.amh.net.au. (Accessed 9 February 2012).
- Servier Laboratories (Aust) Pty Ltd. Valdoxan consumer medicine information. July 2010.
- Servier Laboratories (Aust) Pty Ltd. Valdoxan product information. 8 July 2011. www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-07273-3 (Accessed 22 March 2012).
- Therapeutic Goods Administration. Australian Public Assessment Report for agomelatine. Canberra: TGA, 2010. www.tga.gov.au/pdf/auspar/auspar-valdoxan.pdf (Accessed 7 March 2012).