Clomipramine interactions

Do not take clomipramine with

  • any of the other medicines listed in the table Medicines that may increase risk of serotonin toxicity, unless under careful medical supervision
  • illegal drugs
  • moclobemide and wait at least 2 days after stopping moclobemide before taking clomipramine, because it may cause serotonin toxicity or a serious reaction with severe high blood pressure.

See also

Tell your doctor if you are taking any of the following

Always tell your doctor about all other medicines you are taking, including over-the-counter and complementary or alternative medicines. You may need careful monitoring or a change in dose to avoid side effects if you are taking other medicines, including:

  • sleeping tablets or sedatives
  • medicines for anxiety
  • antipsychotic medicines used to treat certain mental health conditions such as schizophrenia, eg, olanzapine (eg, Lanzek, Ozin, Zylap, Zypine, Zyprexa) and risperidone (eg, Ozidal, Resdone, Risperdal)
  • medicines for high blood pressure or irregular heart beats
  • cough and cold products including nose drops, such as those containing diphenhydramine (eg, in Benadryl) and chlorpheniramine (eg, in Demazin and Codral cold and flu preparations), and brompheniramine (eg, in Demazin and Dimetapp could and cold preparations)
  • antihistamines, medicines for allergy, hayfever or travel sickness (eg, Travacalm)
  • medicines to relieve stomach and bowel cramps or spasms, such as hyoscine (eg. Buscopan, Donnatabs, Kwells, Setacol, Stomex) and mebeverine (Colese, Colofac)
  • medicines for Parkinson’s disease, such as biperiden (Kineton) and benztropine (Benztrop, Cogentin)
    medicines for epilepsy, such as carbamazepine (eg, Teril, Tegretol) or phenytoin (eg, Dilantin)
    medicines to prevent blood clots, such as warfarin (Coumadin, Marevan)
  • cimetidine (eg, Tagamet, Magicul), a medicine used to treat gastric reflux and stomach ulcers
    methylphenidate (eg, Attenta, Ritalin), a medicine used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy
  • medicines containing oestrogen, such as birth control pills and hormone replacement therapy
  • nicotine in medicines used to help you quit smoking, such as nicotine gum, patches, lozenges or inhalers
  • diuretics (fluid tablets)
  • disulfiram (Antabuse), a medicine used to deter alcohol consumption
  • medicines for thyroid problems
  • antibiotics such as erythromycin (eg, EES, Eryc), clarithromycin (eg, Clarac, Klacid) and Rifampicin (Rifadin, Rimycin)
  • fluconazole (eg, Diflucan, Dizole, Fluzole, Ozole)
  • bupropion (Prexaton, Zyban), for quitting smoking.

Clomipramine and alcohol

Clomipramine can make the effects of alcohol stronger. Talk to your doctor about safe limits for you.

Who can I ask about interactions?

Call the NPS Medicines Line on 1300 MEDICINE (1300 633 424) to get information about your prescription, over-the-counter and complementary medicines (herbal, ‘natural’, vitamins and minerals) from a pharmacist. Your call will be answered by healthdirect Australia.

Find out more about

If you are starting clomipramine, see 10 things you should know about antidepressants.

You can also read more about depression and the options for treating it.

For more information

The consumer medicine information (CMI) for your brand of clomipramine is available from our website or a pharmacist. If you have any concerns about interactions, talk to your health professional. The CMI includes:

  • how to take this medicine
  • what to do if you forget to take it
  • if you take too much (overdose)
  • things you must and must not do while taking this medicine
  • signs of severe reactions and what to do.
  • Rossi S, ed. eAMH [online]. Adelaide: Australian Medicines Handbook, 2012. (Accessed 9 February 2012).
  • Psychotropic Expert Group. Therapeutic Guidelines: Psychotropic, Version 6. In: eTG complete [CD-ROM]. Melbourne: Therapeutic Guidelines Limited; 2008.
  • Alphapharm Pty Limited. Placil consumer medicine information. 5 May 2008. (Accessed 22 March 2012).