Desvenlafaxine interactions

Do not take desvenlafaxine with

  • any of the other medicines listed in the table Medicines that may increase risk of serotonin toxicity, unless under careful medical supervision
  • illegal drugs
  • moclobemide and wait at least 2 days after stopping moclobemide before taking desvenlafaxine, because it may cause serotonin toxicity or a serious reaction with severe high blood pressure.

See also

Tell your doctor if you are taking any of the following

Always tell your doctor about all other medicines you are taking, including over-the-counter and complementary or alternative medicines. You may need careful monitoring or a change in dose to avoid side effects if you are taking other medicines, including:

  • any medicines for bipolar disorder, anxiety, obsessive–compulsive disorder or pre-menstrual dysphoric disorder, including the herbal medicine St John's wort
  • medicines for weight loss, including phentermine (Duromine, Metermine)
  • the antibiotic linezolid (Zyvox)
  • bupropion (Prexaton, Zyban) for stopping smoking.

Who can I ask about interactions?

Call the NPS Medicines Line on 1300 MEDICINE (1300 633 424) to get information about your prescription, over-the-counter and complementary medicines (herbal, ‘natural’, vitamins and minerals) from a pharmacist. Your call will be answered by healthdirect Australia.

Desvenlafaxine and alcohol

Desvenlafaxine is not likely to increase the effects of alcohol, but but alcohol can make you feel worse if you are depressed.

Find out more about

If you are starting desvenlafaxine, see 10 things you should know about antidepressants.

You can also read more about depression and the options for treating it.

For more information

The consumer medicine information (CMI) for your brand of desvenlafaxine is available from our website or a pharmacist. If you have any concerns about interactions, talk to your health professional. The CMI includes:

  • how to take this medicine
  • what to do if you forget to take it
  • if you take too much (overdose)
  • things you must and must not do while taking this medicine
  • signs of severe reactions and what to do.
  • Rossi S, ed. eAMH [online]. Adelaide: Australian Medicines Handbook, 2012. (Accessed 9 February 2012).
  • Psychotropic Expert Group. Therapeutic Guidelines: Psychotropic, Version 6. In: eTG complete [CD-ROM]. Melbourne: Therapeutic Guidelines Limited; 2008.
  • Pfizer Australia Pty Ltd. Pristiq consumer medicine information. 2 May 2011. (Accessed 22 March 2012).