Do not take doxepin with
- any of the other medicines listed in the table Medicines that may increase risk of serotonin toxicity, unless under careful medical supervision
- illegal drugs
- moclobemide and wait at least 2 days after stopping moclobemide before taking doxepin, because it may cause serotonin toxicity or a serious reaction with severe high blood pressure.
Tell your doctor if you are taking any of the following
Always tell your doctor about all other medicines you are taking, including over-the-counter and complementary or alternative medicines. You may need careful monitoring or a change in dose to avoid side effects if you are taking other medicines, including:
- cough and cold products including nose drops, such as those containing diphenhydramine (in some Benadryl products), chlorpheniramine (in some Demazin and Codral cold and flu products) and brompheniramine (in some Demazin and Dimetapp cough and cold products)
- antihistamines, medicines for allergy, hayfever or travel sickness (eg, Travacalm)
- cimetidine (Magicul, Tagamet) a medicine for stomach ulcers or gastric reflux
- medicines for high blood pressure
- medicines for diabetes, such as glibenclamide (Daonil, Glimel, Glucovance) and glipizide (Melizide, Minidiab)
- anti-anxiety medicines, such as diazepam (eg, Valium, Serepax)
- medicines containing atropine (Atropt) or medicines for irritable bowel syndrome, such as propantheline (Pro-Banthine)
- medicines to relieve stomach and bowel cramps or spasms, such as hyoscine (Buscopan, Donnatab, Kwells, Setacol, Stomex) and mebeverine (Colese, Colofac)
- antipsychotic medicines used to treat certain mental health conditions such as schizophrenia, eg, olanzapine (eg, Lanzek, Ozin, Zylap, Zypine, Zyprexa) and risperidone (eg, Ozidal, Resdone, Risperdal)
- medicines for controlling irregular heart beats, such as flecainide (Flecatab, Tambocor)
- medicines for epilepsy such as carbamazepine (Tegretol, Teril), or phenytoin (Dilantin)
- medicines that contain or act like adrenaline or noradrenaline (eg, nasal drops, decongestants, some cough mixtures and some local anaesthetics)
- stimulant medicines containing amphetamines (eg, dexamphetamine)
- antibiotics such as erythromycin (eg, EES, Eryc) and clarithromycin (eg, Clarac, Klacid)
- bupropion (Prexaton, Zyban), for quitting smoking
- fluconazole (eg, Diflucan, Dizole, Fluzole, Ozole), for fungal infections.
Doxepin and alcohol
Doxepin can make the effects of alcohol stronger. Talk to your doctor about safe limits for you.
Who can I ask about interactions?
Call the NPS Medicines Line on 1300 MEDICINE (1300 633 424) to get information about your prescription, over-the-counter and complementary medicines (herbal, ‘natural’, vitamins and minerals) from a pharmacist. Your call will be answered by healthdirect Australia.
Find out more about
- What doxepin does and how effective it is
- Who doxepin is for and who should be cautious
- Side effects of doxepin
- Brands of doxepin
If you are starting doxepin, see 10 things you should know about antidepressants.
For more information
- Starting, switching and stopping antidepressants
- Managing side effects of antidepressants
- Psychological therapies
The consumer medicine information (CMI) for your brand of doxepin is available from our website or a pharmacist. If you have any concerns about interactions, talk to your health professional. The CMI includes:
- how to take this medicine
- what to do if you forget to take it
- if you take too much (overdose)
- things you must and must not do while taking this medicine
- signs of severe reactions and what to do.
- Rossi S, ed. eAMH [online]. Adelaide: Australian Medicines Handbook, 2012. www.amh.net.au. (Accessed 9 February 2012).
- Psychotropic Expert Group. Therapeutic Guidelines: Psychotropic, Version 6. In: eTG complete [CD-ROM]. Melbourne: Therapeutic Guidelines Limited; 2008.
- Pfizer Australia Pty Limited. Sinequan consumer medicine information. 16 April 2008. (Accessed 22 March 2012).