Imipramine interactions

Do not take imipramine with

  • any of the other medicines listed in the table Medicines that may increase risk of serotonin toxicity, unless under careful medical supervision
  • illegal drugs
  • moclobemide and wait at least 2 days after stopping moclobemide before taking imipramine, because it may cause serotonin toxicity or a serious reaction with severe high blood pressure.

See also

Tell your doctor if you are taking any of the following

Always tell your doctor about all other medicines you are taking, including over-the-counter and complementary or alternative medicines. You may need careful monitoring or a change in dose to avoid side effects if you are taking other medicines, including:

  • medicines for high blood pressure
  • medicines used to control an irregular heart beat, such as flecainide (Tambocor, Flecatab)
  • sleeping tablets or anti-anxiety medicines
  • antipsychotic medicines used to treat certain mental health conditions such as schizophrenia, eg, olanzapine (eg, Lanzek, Ozin, Zylap, Zypine, Zyprexa) and risperidone (eg, Ozidal, Resdone, Risperdal)
  • medicines for epilepsy, such as carbamazepine (Tegretol, Teril)
  • medicines that increase the risk of gastrointestinal bleeding such as warfarin (Coumadin, Marevan), ticlopidine (Tilodene), aspirin (eg, Aspro) and nonsteroidal anti-inflammatory drugs, used to treat pain and inflammation.
  • cough and cold products including nose drops, such as those containing diphenhydramine (eg, in some Benadryl products), chlorpheniramine (eg, in some Demazin and Codral cold and flu products) and brompheniramine (in some Demazin and Dimetapp cough and cold products)
  • antihistamines, medicines for allergy, hayfever or travel sickness (eg, Travacalm)
  • medicines for thyroid problems
  • medicines to relieve stomach and bowel cramps or spasms, such as hyoscine (eg, Buscopan, Donnatab, Kwells, Setacol, Stomex) and mebeverine (Colese, Colofac)
  • cimetidine (Magicul, Tagamet), a medicine for stomach ulcers or gastric reflux
  • medicines for Parkinson's disease
  • oestrogens (birth control pills, hormone replacement therapy)
  • nicotine in medicines used to help you quit smoking, such as nicotine patches or chewing gum
  • methylphenidate (Concerta, Ritalin), for attention deficit hyperactivity disorder or narcolepsy
  • disulfiram (Antabuse), a medicine for alcoholism
  • antibiotics such as erythromycin (eg, EES, Eryc) and clarithromycin (eg, Clarac, Klacid)
  • fluconazole (eg, Diflucan, Dizole, Fluzole, Ozole), for fungal infections
  • bupropion (Prexaton, Zyban), for quitting smoking.

Imipramine and alcohol

Imipramine can make the effects of alcohol stronger. Talk to your doctor about safe limits for you.

Who can I ask about interactions?

Call the NPS Medicines Line on 1300 MEDICINE (1300 633 424) to get information about your prescription, over-the-counter and complementary medicines (herbal, ‘natural’, vitamins and minerals) from a pharmacist. Your call will be answered by healthdirect Australia.

Find out more about

If you are starting imipramine, see 10 things you should know about antidepressants.

You can also read more about depression and the options for treating it.

For more information

The consumer medicine information (CMI) for your brand of imipramine is available from our website or a pharmacist. If you have any concerns about interactions, talk to your health professional. The CMI includes:

  • how to take this medicine
  • what to do if you forget to take it
  • if you take too much (overdose)
  • things you must and must not do while taking this medicine
  • signs of severe reactions and what to do.
  • Rossi S, ed. eAMH [online]. Adelaide: Australian Medicines Handbook, 2012. (Accessed 9 February 2012).
  • Psychotropic Expert Group. Therapeutic Guidelines: Psychotropic, Version 6. In: eTG complete [CD-ROM]. Melbourne: Therapeutic Guidelines Limited; 2008.
  • Link Medical Products Pty Ltd. Tofranil consumer medicine information. 20 July 2011. (Accessed 22 March 2012).