Mianserin interactions

Do not take mianserin with

  • any of the other medicines listed in the table Medicines that may increase risk of serotonin toxicity, unless under careful medical supervision
  • illegal drugs
  • moclobemide and wait at least 2 days after stopping moclobemide before taking mianserin, because it may cause serotonin toxicity or a serious reaction with severe high blood pressure.

See also

Tell your doctor if you are taking any of the following

Always tell your doctor or pharmacist about all other medicines you are taking, including over-the-counter and complementary or alternative medicines. You may need careful monitoring or a change in dose to avoid side effects if you are taking other medicines, including:

  • any other medicines for depression
  • medicines used to treat epilepsy such as barbiturates such as phenobarbitone and primidone (Mysoline), carbamazepine (Tegretol, Teril) or phenytoin (Dilantin)
  • medicines used to treat high blood pressure
  • oral antidiabetic medicines or insulin
  • medicines that increase the risk of gastrointestinal bleeding such as warfarin (Coumadin, Marevan), ticlopidine (Tilodene), aspirin (Aspro) and nonsteroidal anti-inflammatory drugs, used to treat pain and inflammation
  • bupropion (Prexaton, Zyban) for stopping smoking.

Mianserin and alcohol

Mianserin may increase the effects of alcohol. Talk to your doctor about safe limits for you.

Who can I ask about interactions?

Call the NPS Medicines Line on 1300 MEDICINE (1300 633 424) to get information about your prescription, over-the-counter and complementary medicines (herbal, ‘natural’, vitamins and minerals) from a pharmacist. Your call will be answered by healthdirect Australia.

Find out more about

If you are starting mianserin, see 10 things you should know about antidepressants.

You can also read more about depression and the options for treating it.

For more information

The consumer medicine information (CMI) for your brand of mianserin is available from our website or a pharmacist. If you have any concerns about interactions, talk to your health professional. The CMI includes:

  • How to take this medicine
  • What to do if you forget to take it
  • If you take too much (overdose)
  • Things you must and must not do while taking this medicine
  • Signs of severe reactions and what to do.
  • Rossi S, ed. eAMH [online]. Adelaide: Australian Medicines Handbook, 2012. www.amh.net.au. (Accessed 9 February 2012).
  • Psychotropic Expert Group. Therapeutic Guidelines: Psychotropic, Version 6. In: eTG complete [CD-ROM]. Melbourne: Therapeutic Guidelines Limited; 2008.
  • Merck Sharp and Dohme (Australia) Pty Ltd. Tolvon consumer medicine information. December 2011. (Accessed 22 March 2012).