Moclobemide interactions

Do not take moclobemide with

  • any of the other medicines listed in the table Medicines that may increase risk of serotonin toxicity, unless under careful medical supervision. Taking moclobemide with these medicines may cause a serious reaction called serotonin toxicity. This can cause a sudden increase in body temperature, high blood pressure and seizures
  • illegal drugs (e.g. ecstasy, LSD [acid, trips], amphetamines [speed, ice], cocaine
  • methylphenidate (Concerta, Ritalin), medicines for ADHD
  • pseudoephedrine (in many sinus and cold medicines) and ephedrine (prepared by pharmacists as a nasal medicine)
  • phenylephrine (in many cough and cold medicines).

Taking moclobemide with any of these medicines may cause a dangerous reaction with severe high blood pressure.

After you stop taking moclobemide, wait at least 2 days before taking any medicines in the list above because they may still cause an interaction resulting in severe high blood pressure or serotonin toxicity during this time.

See also

Tell your doctor if you are taking any of the following

Always tell your doctor or pharmacist about all other medicines you are taking, including over-the-counter and complementary or alternative medicines. You may need careful monitoring or a change in dose to avoid side effects if you are taking other medicines, including:

  • cimetidine (Magicul, Tagamet), for stomach disorders
  • metopropolol (Betaloc, Lopresor, Metrol, Toprol-XL), for heart conditions, high blood pressure or migraine
  • cough or cold medicines.

Moclobemide and alcohol

Moclobemide is unlikely to affect your response to alcohol. It is generally not a good idea to drink alcohol if you are depressed or taking antidepressants.

Who can I ask about interactions?

Call the NPS Medicines Line on 1300 MEDICINE (1300 633 424) to get information about your prescription, over-the-counter and complementary medicines (herbal, ‘natural’, vitamins and minerals) from a pharmacist. Your call will be answered by healthdirect Australia.

Find out more about

If you are starting moclobemide, see 10 things you should know about antidepressants.

You can also read more about depression and the options for treating it.

For more information

The consumer medicine information (CMI) for your brand of moclobemide is available from our website or a pharmacist. If you have any concerns about interactions, talk to your health professional. The CMI includes:

  • how to take this medicine
  • what to do if you forget to take it
  • if you take too much (overdose)
  • things you must and must not do while taking this medicine
  • signs of severe reactions and what to do.
  • Rossi S, ed. eAMH [online]. Adelaide: Australian Medicines Handbook, 2012. (Accessed 9 February 2012).
  • Psychotropic Expert Group. Therapeutic Guidelines: Psychotropic, Version 6. In: eTG complete [CD-ROM]. Melbourne: Therapeutic Guidelines Limited; 2008.
  • Meda Valeant Pharma Australia Pty Limited. Aurorix consumer medicine information. 18 March 2010 (accessed 22 March 2012).