Paroxetine interactions

Do not take paroxetine with

  • any of the other medicines listed in the table Medicines that may increase risk of serotonin toxicity, unless under careful medical supervision
  • illegal drugs
  • moclobemide and wait at least 2 days after stopping moclobemide before taking paroxetine, because it may cause serotonin toxicity or a serious reaction with severe high blood pressure.

See also

Tell your doctor if you are taking any of the following

Always tell your doctor about all other medicines you are taking, including over-the-counter and complementary or alternative medicines. You may need careful monitoring or a change in dose to avoid side effects if you are taking other medicines, including:

  • medicines for anxiety
  • antipsychotic medicines used to treat certain mental health conditions such as schizophrenia, e.g. olanzapine (e.g. Lanzek, Ozin, Zylap, Zypine, Zyprexa) and risperidone (e.g. Ozidal, Resdone, Risperdal)
  • atomoxetine (Strattera), for attention deficit hyperactivity disorder
  • medicines to lower blood pressure, such as metoprolol (Betaloc, Lopresor, Metohexal, Metrol, Minax, Toprol-XL)
  • medicines used to control an irregular heart beat, such as flecainide (Tambocor, Flecatab)
  • epilepsy medicines such as carbamazepine (Tegretol, Teril), or phenytoin (Dilantin)
  • medicines that increase the risk of gastrointestinal bleeding such as warfarin (Coumadin, Marevan), aspirin (e.g. Aspro) and NSAIDs, used to treat pain and inflammation
  • Parkinson’s disease medicines
  • cimetidine (Magicul, Tagamet), for stomach ulcers and gastric reflux
  • tamoxifen (Genox, Nolvadex, Tamosin, Tamoxen), to treat or prevent breast cancer
  • HIV medicines, such as darunavir (Prezista)
  • Galantamine (Galantyl, Reminyl), for Alzheimer’s disease
  • bupropion (Prexaton, Zyban) for stopping smoking.

Paroxetine and alcohol

Paroxetine is not likely to increase the effects of alcohol, but alcohol can make you feel worse if you are depressed.

Who can I ask about interactions?

Call the NPS Medicines Line on 1300 MEDICINE (1300 633 424) to get information about your prescription, over-the-counter and complementary medicines (herbal, ‘natural’, vitamins and minerals) from a pharmacist. Your call will be answered by healthdirect Australia.

Find out more about

If you are starting paroxetine, see 10 things you should know about antidepressants.

You can also read more about depression and the options for treating it.

For more information

The consumer medicine information (CMI) for your brand of paroxetine is available from our website or a pharmacist. If you have any concerns about interactions, talk to your health professional. The CMI includes:

  • how to take this medicine
  • what to do if you forget to take it
  • if you take too much (overdose)
  • things you must and must not do while taking this medicine
  • signs of severe reactions and what to do.
  • Rossi S, ed. eAMH [online]. Adelaide: Australian Medicines Handbook, 2012. (Accessed 9 February 2012).
  • Psychotropic Expert Group. Therapeutic Guidelines: Psychotropic, Version 6. In: eTG complete [CD-ROM]. Melbourne: Therapeutic Guidelines Limited; 2008.
  • GlaxoSmithKline Australia Pty Ltd. Aropax consumer medicine information. 2 January 2011. (Accessed 22 March 2012).