Sertraline interactions

Do not take sertraline with

  • any of the other medicines listed in the table Medicines that may increase risk of serotonin toxicity, unless under careful medical supervision
  • illegal drugs
  • moclobemide and wait at least 2 days after stopping moclobemide before taking sertraline, because it may cause serotonin toxicity or a serious reaction with severe high blood pressure.

See also

Tell your doctor if you are taking any of the following

Always tell your doctor about all other medicines you are taking, including over-the-counter and complementary or alternative medicines. You may need careful monitoring or a change in dose to avoid side effects if you are taking other medicines, including:

  • other medicines for the treatment of panic disorder, social anxiety disorder or obsessive illnesses or premenstrual dysphoric disorder
  • antipsychotic medicines used to treat certain mental health conditions such as schizophrenia, eg, olanzapine (eg, Lanzek, Ozin, Zylap, Zypine, Zyprexa) and risperidone (eg, Ozidal, Resdone, Risperdal)
  • medicines for irregular heart beat, such as flecainide (Flecatab, Tambocor)
  • medicines that increase the risk of gastrointestinal bleeding such as warfarin (Coumadin, Marevan), ticlopidine (Tilodene), aspirin (eg, Aspro) and NSAIDs, used to treat pain and inflammation
  • phenytoin (Dilantin), a medicine used to treat epilepsy
  • migraine medicines
  • diazepam (eg, Antenex, Ranzepam, Valium, Valpam) or oxazepam (eg, Alepam, Murelax, Serepax)
  • cimetidine (Magicul, Tagamet), a medicine used to treat gastric reflux and stomach ulcers
    diabetes medicines
  • methadone (Biodone), a medicine used to treat drug addiction
  • bupropion (Prexaton, Zyban) for stopping smoking.

Sertraline and alcohol

Sertraline is not likely to increase the effects of alcohol, but alcohol can make you feel worse if you are depressed.

Who can I ask about interactions?

Call the NPS Medicines Line on 1300 MEDICINE (1300 633 424) to get information about your prescription, over-the-counter and complementary medicines (herbal, ‘natural’, vitamins and minerals) from a pharmacist. Your call will be answered by healthdirect Australia.

Find out more about

If you are starting sertraline, see 10 things you should know about antidepressants.

You can also read more about depression and the options for treating it.

For more information

The consumer medicine information (CMI) for your brand of sertraline is available from our website or a pharmacist. If you have any concerns about interactions, talk to your health professional. The CMI includes:

  • how to take this medicine
  • what to do if you forget to take it
  • if you take too much (overdose)
  • things you must and must not do while taking this medicine
  • signs of severe reactions and what to do.
  • Rossi S, ed. eAMH [online]. Adelaide: Australian Medicines Handbook, 2012. (Accessed 9 February 2012).
  • Psychotropic Expert Group. Therapeutic Guidelines: Psychotropic, Version 6. In: eTG complete [CD-ROM]. Melbourne: Therapeutic Guidelines Limited; 2008.
  • Pfizer Australia Pty Ltd. Zoloft consumer medicine information. December 2011. (Accessed 22 March 2012).