Aloxi Solution for infusion

Aloxi Solution for infusion is a brand of medicine containing the active ingredient palonosetron.

Find out more about active ingredients.

Consumer medicine information (CMI) leaflet

Developed by the pharmaceutical company responsible for this medicine in Australia, according to TGA regulations.

ALOXI®

Palonosetron 250 mcg per 5 mL solution for injection


Consumer Medicine Information

What is in this leaflet

This leaflet answers some common questions about ALOXI. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist.

All medicines have risks and benefits. Your doctor has weighed the risks of you using this medicine against the benefits it is expected to have for you.

If you have any concerns about taking this medicine, ask your doctor or pharmacist.

Keep this leaflet. You may need to read it again.

Back to top

What ALOXI is used for

This medicine belongs to a group of medicines known as serotonin (5-HT3) antagonists and is a colourless solution for injection into a vein.

It is used for the prevention of nausea and vomiting associated with cancer chemotherapy.

Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed this medicine for another purpose.

Back to top

Before you are given ALOXI

When you must not be given it

Do not use this medicine if you have an allergy to:

  • palonosetron
  • any of the ingredients listed at the end of this leaflet.

Some of the symptoms of an allergic reaction may include:

  • shortness of breath
  • wheezing or difficulty breathing or a tight feeling in your chest
  • swelling of the face, lips, tongue or other parts of the body
  • rash, itching or hives on the skin

ALOXI should not be used to prevent or treat nausea and vomiting in the days following chemotherapy if not associated with another chemotherapy administration.

Before you are given it

You doctor must know about all of the following before you are given this medicine.

Tell your doctor or pharmacist if you have allergies to medicines or any other medicines, foods, preservatives or dyes.

Tell your doctor if you are pregnant or think you might be. Your doctor will not use this medicine unless it is clearly necessary as it is not known whether it will cause any harmful effects when used during pregnancy. You should always ask your doctor or pharmacist for advice before using any medicine if you are pregnant or think you might be.

Tell your doctor if you are breast-feeding. It is not known if this medicine is found in breast milk. You should ask your doctor or pharmacist for advice before using it if you are breast-feeding.

If you have not told your doctor about any of the above, tell him/her before you are given this medicine.

Taking or being given other medicines

Tell your doctor if you are taking any other medicines, including any that you get without a prescription from your pharmacy, supermarket or health food shop.

Some medicines may affect the way other medicines work. Your doctor or pharmacist will be able to tell you what to do when being given this medicine with other medicines.

Back to top

How ALOXI is given

This medicine is given as an injection into a vein. A doctor or nurse will normally inject it about 30 minutes before the start of chemotherapy.

Your doctor will decide how much of this medicine you will be given and for how long.

If you take too much (overdose)

As this medicine is given to you under the supervision of your doctor, it is very unlikely that you will receive too much. However, if you experience any side effects after being given it, tell your doctor immediately.

Back to top

While you are using ALOXI

Things you must do

If the medicine starts to upset you and your symptoms become worse, tell your doctor.

Tell any other doctors, dentists, and pharmacists who are treating you that you are being treated with this medicine.

Tell your doctor if you become pregnant during treatment with this medicine.

Things to be careful of

It is not known if this medicine has any effect on your ability to drive or use machines. You should be certain that you are able to drive and operate machines before you try.

Back to top

Side effects

Tell your doctor, nurse or pharmacist as soon as possible if you do not feel well while you are being given this medicine. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical attention if you get some of the side effects.

Do not be alarmed by the following lists of side effects. You may not experience any of them.

Ask your doctor or pharmacist to answer any questions you may have.

The following common side effects may occur.

  • Headache
  • Dizziness
  • Constipation
  • Diarrhoea

Tell your doctor, nurse or pharmacist if you notice any of the following and they worry you:

The following uncommon side effects may also occur.

  • Loss of appetite
  • Anxiety or euphoria
  • Sleep disturbances
  • Change of sensation in your limbs
  • Visual or hearing disturbances
  • Motion sickness
  • Change in heart rate
  • Prominent or discoloured veins
  • Hiccups, flatulence or dry mouth
  • Upset stomach or stomach pains
  • Rash
  • Joint pain
  • Difficulty passing water
  • Weakness or tiredness
  • Fever or a flu-like illness

The above list includes the more common side effects of your medicine. They are usually mild and short-lived.

You should tell your doctor if you notice any of the above effects.

Your doctor will tell you if the following uncommon side effects occur.

  • changes in the amounts of certain substances in your blood or urine
  • changes in your blood pressure

Other side effects not listed above may also occur in some people.

Tell your doctor if you notice any other effects.

Back to top

After receiving ALOXI

Storage

Store in the original container. Keep the container in the outer carton in order to protect from light.

Keep in a cool dry place where the temperature stays below 25°C.

Keep out of the reach and sight of children.

Do not use this medicine if the expiry date printed on the pack has passed.

Back to top

Product description

What it looks like

This medicine is a colourless solution. It is supplied in a pack of one glass vial, which contains 5 mL of the solution. Each vial contains enough for one dose.

Ingredients

ALOXI contains 250 mcg of Palonosetron (as the hydrochloride) as the active ingredient.

Inactive ingredients

  • Mannitol
  • Disodium edetate
  • Sodium citrate
  • Citric acid monohydrate
  • Sodium hydroxide
  • Hydrochloric acid
  • Water for injections

Supplier

ALOXI is supplied in Australia by:
Mundipharma Pty Limited
88 Phillip Street
Sydney NSW 2000
AUSTRALIA

In New Zealand:
Mundipharma New Zealand Limited
C/Pharmaco (NZ) Limited
Auckland, NEW ZEALAND

This leaflet was prepared in April 2016.

Australian Registration Number
ALOXI 250 mcg per 5 mL injection
AUST R 114185

® ALOXI is a registered trade mark of Helsinn Healthcare SA, Switzerland.

Orbis AU-3294

Back to top

CMI provided by MIMS Australia, January 2017  

Related information - Aloxi Solution for infusion

Audience:
       

(Medicine)
06 Jun 2016 Information on medicines available in Australia containing palonosetron, including our latest evidence-based information and resources for health professionals and consumers. The active ingredient is the chemical in a medicine that makes it work. Medicines that contain the same active ingredient can be available under more than one brand name. Brands include both active ingredients and inactive ingredients. You'll find information about brands of medicines that contain palonosetron below, including their consumer medicine information (CMI) leaflets.