Heartburn and reflux medicines

Proton pump inhibitors (PPIs)

Find reliable, independent information about heartburn and reflux medicines written by Australian experts.

About this medicine

Heartburn and reflux medicines may be recommended by your health professional if lifestyle changes have not been enough to help you manage the symptoms of reflux - also known as gastro-oesophageal reflux disease (or GORD).

Proton pump inhibitors (PPIs) are a type of heartburn and reflux medicine that work by reducing the amount of stomach acid produced. PPIs are generally safe to use and are more effective than other heartburn and reflux medicines.

PPIs are usually only needed short term, until your heartburn and reflux symptoms are under control. If you've been taking a PPI for more than 4-8 weeks, talk to your doctor about reviewing your medicines, as you may be able to reduce your dose or stop altogether.

Find out more

For health professionals  

Several studies suggest that a substantial proportion of proton pump inhibitor (PPI) use may not be appropriate. Review patients who have been taking a PPI long term to evaluate if ongoing treatment is still indicated

PPIs achieve prolonged and irreversible inhibition of gastric acid production, and are a generally safe class of medicine, which has contributed to their increasing use.

PPIs are used in the management of several acid–peptic disorders, including gastro-oesophageal reflux disease (GORD)  and peptic ulcer disease.

Our CPD activities

Consolidate your knowledge on PPIs, brush-up on current guidelines and practices and earn CPD points through our learning activities.

For your patients

Use the following resources in your consultations with your patient:

Clinical information

The information below uses the latest guidelines and evidence to help health professionals further understand the issues around PPI use. It also includes tools and resources to help educate patients and carers.

Other tools and resources

Related information - heartburn and reflux medicines


For health professionals
13 Oct 2016 Find out which tests, treatments or procedures healthcare providers and consumers should question, as recommended by Australian medical colleges.
For health professionals
14 Mar 2016 Proton pump inhibitors (PPIs) may be used to treat heartburn, reflux, gastro-oesophageal reflux disease (GORD) & peptic ulcers. Learn about PPIs and managing acid-peptic disorders.
For health professionals
14 Mar 2016 Proton pump inhibitors (PPIs) are indicated for heartburn, reflux, gastro-oesophageal reflux disease (GORD) and peptic ulcers. Learn more about prescribing PPIs.
14 Mar 2016 Heartburn and reflux medicines (proton pump inhibitors) are often only needed for a short time. Download a factsheet about managing heartburn and reflux.
For health professionals (CPD activity)
30 Jun 2015 This Clinical e-Audit is designed for GPs and helps identify which patients on long-term proton pump inhibitor (PPI) therapy could benefit from a step-down approach.
(Consumer publication)
27 May 2015 Medicines to treat heartburn and reflux may be recommended if changes to your diet and lifestyle have not been enough to manage symptoms. But you may not need them long-tern
22 Apr 2015
Recommendations from the Royal Australian College of General Practitioners (RACGP) on treating hypertension or hyperlipidaemia, prescribing benzodiazepines, self-monitoring of blood glucose, proton pump inhibitor therapy and screening for vascular disease.
(Media release)
02 Apr 2015 NPS MedicineWise today launches a new learning program and health professional tools on the use of proton pump inhibitors (PPIs) in the treatment of uncomplicated gastro-oesophageal reflux disease (GORD). The program focuses on optimal use of PPIs and provides practice points and tools to facilitate step-down therapy in patients whose symptoms are well controlled.
(Media release)
02 Apr 2015 Daily use of heartburn and reflux medicines (such as proton pump inhibitors or PPIs) for treatment of gastro-oesophageal reflux disease (GORD) symptoms may not be necessary. Read more.
For health professionals (Medicine)
01 Apr 2015 This poster for patients on use of heartburn and reflux medicines (such as proton pump inhibitors or PPIs) suggests review of medicine use with doctors.