Indosyl Combi 4/1.25 Tablets
Indosyl Combi 4/1.25 Tablets is a brand of medicine containing the active ingredients perindopril erbumine - indapamide hemihydrate.
Find out more about active ingredients.
Consumer medicine information (CMI) leaflet
Developed by the pharmaceutical company responsible for this medicine in Australia, according to TGA regulations.
INDOSYL® COMBI 4/1.25
perindopril (pronounced per-in-do-pril) and indapamide (pronounced in-dap-a-mide)
Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about INDOSYL COMBI 4/1.25. It does not contain all the available information about this medicine. Reading this leaflet does not take the place of talking to your doctor or pharmacist.
All medicines have risks and benefits. Your doctor has weighed the risks of you taking INDOSYL COMBI 4/1.25 against the expected benefits for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine. You may need to read it again.
What INDOSYL COMBI 4/1.25 is
The name of your medicine is INDOSYL COMBI 4/1.25. The medicine contains the active ingredients perindopril erbumine and indapamide hemihydrate. Perindopril belongs to a group of medicines called angiotensin converting enzyme (ACE) inhibitors. Indapamide belongs to a group of medicines called chlorosulphamoyl diuretics.
What INDOSYL COMBI 4/1.25 is used for
You have been prescribed INDOSYL COMBI 4/1.25 for high blood pressure.
INDOSYL COMBI 4/1.25 is available only with a doctor's prescription.
There is no evidence that INDOSYL COMBI 4/1.25 is addictive.
Why INDOSYL COMBI 4/1.25 is used for high blood pressure
Everyone has blood pressure. This pressure helps to circulate blood all around the body. Your blood pressure may be different at different times of the day, depending on how busy or stressed you are. You have high blood pressure (also known as hypertension) when your blood pressure stays higher than is needed, even when you are calm and relaxed.
If high blood pressure is not treated it can lead to serious health problems. You may feel fine and have no symptoms, but eventually it can cause stroke, heart disease and kidney failure.
INDOSYL COMBI 4/1.25 helps to lower your blood pressure.
Ask your doctor if you have any questions about why INDOSYL COMBI 4/1.25 has been prescribed for you.
Before you take INDOSYL COMBI 4/1.25
There are some people who should not take INDOSYL COMBI 4/1.25. Please read the lists below. If you think any of these situations apply to you, or you have any questions, please consult your doctor or pharmacist.
Do not take INDOSYL COMBI 4/1.25 if:
- You are allergic to perindopril, indapamide, or any of the other ingredients of INDOSYL COMBI 4/1.25 listed at the end of this leaflet.
- You are allergic to sulphonamide (sulpha) antibiotics, or to thiazide diuretics (a type of "fluid" or "water" tablet).
- You are allergic to another angiotensin converting enzyme (ACE) inhibitor.
- You are pregnant or trying to become pregnant.
- You are breastfeeding or plan to breast-feed.
- You undergo renal dialysis using polyacrylonitrile membranes.
- You have a narrowing of the blood vessels to one or both kidneys.
- You have narrowing of the main blood vessel leading from the heart and/or heart valve.
- You have experienced serious swelling of the face, tongue, lips or throat either suddenly or in response to another medicine in the past (a rare allergic condition known as angio-oedema).
- The packaging is damaged or shows signs of tampering, or the tablets do not look quite right.
- The expiry date (EXP) on the pack has passed.
Tell your doctor straight away if:
- You are pregnant or become pregnant while taking INDOSYL COMBI 4/1.25, as it may cause serious harm to your unborn baby.
- You are undergoing desensitisation treatment, or have had an allergic reaction during previous desensitisation treatment (e.g. treatments using bee, wasp or ant venom).
- You are undergoing, or have had an allergic reaction during previous, low-density lipoprotein (LDL) apheresis, a technique where LDL is ‘filtered’ out of a patient’s blood, using dextran sulphate.
- You have recently suffered from diarrhoea or vomiting.
- You are on a salt restricted diet or use salt substitutes which contain potassium.
- You have an intolerance to some sugars as INDOSYL COMBI 4/1.25 contains lactose.
- You have any other health problems, including:
- Kidney disease or if you are on renal dialysis.
- Liver disease.
- High or low levels of potassium, sodium, or other problems with salt balance.
- Heart disease.
- Systemic lupus erythematosus or scleroderma (a disease affecting the skin, joints and kidneys).
Taking other medicines
Tell your doctor if you are taking any other medicines, including medicines that you buy without a prescription from a pharmacy, supermarket or health food shop.
Taking INDOSYL COMBI 4/1.25 may change the effect of some medicines, and some medicines may affect how well INDOSYL COMBI 4/1.25 works. You may need different amounts of your medication or to take different medicines. The medicines that may interact with INDOSYL COMBI 4/1.25 include the following:
- Some anaesthetic drugs.
- Some antibiotic drugs.
- Some anti-inflammatory drugs (including high dose aspirin, ibuprofen) for pain relief.
- Some steroid medicines.
- Some drugs used to treat cancer or to suppress the immune system.
- Medicines used to treat mood swings and some types of depression (lithium, tricyclic antidepressants, antipsychotics).
- Sources of potassium, like potassium tablets and salt substitutes containing potassium.
- Some medications used to treat high blood pressure (including angiotensin receptor blocker, diuretics (sometimes called "fluid" or "water" tablets because they increase the amount of urine passed each day)
- Vasodilators including nitrates
- Heparin (used to thin blood).
- Immunosuppressants (medicines which reduces the activity of the body’s natural defences).
- Medicines which may affect the blood cells, such as allopurinol, procainamide.
- Medicines used to treat diabetes (tablets and insulin).
Your doctor or pharmacist has more information on medicines to be careful with or avoid while taking INDOSYL COMBI 4/1.25.
For older people or children
- Elderly people can generally use INDOSYL COMBI 4/1.25 safely. However, some older people have reduced kidney function - in which case additional care may be required.
- INDOSYL COMBI 4/1.25 is not recommended for use in children.
How to take INDOSYL COMBI 4/1.25
Follow all directions given to you by your doctor and pharmacist carefully. If you do not understand the instructions on the label, ask your doctor or pharmacist for help.
Your doctor will select a dose when they prescribe INDOSYL COMBI 4/1.25 for you. The usual dose is one tablet once daily.
Swallow your tablet(s) with water, preferably in the morning.
How long to take INDOSYL COMBI 4/1.25 for
INDOSYL COMBI 4/1.25 can help to control your blood pressure but cannot cure this condition. INDOSYL COMBI 4/1.25 treatment is usually for life - so you should keep taking the tablets regularly unless advised otherwise by your doctor.
If you forget to take INDOSYL COMBI 4/1.25
- If your next usual dose is less than 6 hours away, just leave out the dose that you missed. Take the next dose at the usual time and continue as normal.
- If your next dose is more than 6 hours away, take the dose you have missed as soon as you realise. Then take the next dose at the usual time and continue as normal.
Do not try to make up for missed doses by taking more than one dose at a time.
If you take too much INDOSYL COMBI 4/1.25
Taking too much INDOSYL COMBI 4/1.25 (an overdose) may cause low blood pressure (also known as hypotension). The most likely effect in case of overdose is low blood pressure which can make you feel dizzy or faint. If this happens, lying down with the legs elevated can help. Other effects like sickness, cramps, sleepiness, confusion, kidney problems, salt and water disturbances are possible. You may require urgent medical attention.
If you think that you or anyone else may have taken too much INDOSYL COMBI 4/1.25 then act immediately:
- Telephone your doctor or the Poisons Information Centre (13 11 26 in Australia; 03 474 7000 in New Zealand), or go to the Accident and Emergency department at your nearest hospital. Do this even if there are no signs of discomfort or poisoning.
While you are taking INDOSYL COMBI 4/1.25
Things you must do
Take INDOSYL COMBI 4/1.25 exactly as your doctor has prescribed. Otherwise you may not get the benefits from treatment. Tell all doctors, dentists and pharmacists who are involved with your treatment that you are taking INDOSYL COMBI 4/1.25.
Make sure you drink enough water during exercise and hot weather especially if you sweat a lot. This will help you avoid any dizziness or light-headedness caused by a sudden drop in blood pressure.
Tell your doctor straight away if you have excessive vomiting or diarrhoea while taking INDOSYL COMBI 4/1.25
Things you must not do
Do not give this medicine to anyone else, even they have the same condition as you.
Do not use INDOSYL COMBI 4/1.25 to treat any other complaints unless your doctor tells you to.
Do not stop taking INDOSYL COMBI 4/1.25 or change the dose, without checking with your doctor.
Things to be careful of
Be careful when driving or operating machinery until you know how INDOSYL COMBI 4/1.25 affects you. You may feel light-headed or dizzy when you begin to take INDOSYL COMBI 4/1.25. This is because your blood pressure is falling. If you have these symptoms when standing up or getting out of bed then getting up more slowly can help. This allows your body to get used to the change in position and blood pressure.
If you have these symptoms and they don't get better in a short time then talk to your doctor.
If you do not feel well while you are taking INDOSYL COMBI 4/1.25 then tell your doctor or pharmacist as soon as possible. All medicines can have side effects. Sometimes they are serious, most of the time they are not.
INDOSYL COMBI 4/1.25 helps most people with high blood pressure, but it may sometimes have unwanted side effects. These can include:
- A dry cough.
- Feeling tired or as if you have less energy.
- Feeling faint, light-headed, or dizzy.
- Feeling sick or having stomach pain.
- Muscle pain.
- An increased risk of becoming dehydrated (in elderly patients and in patients with heart failure).
- Low potassium levels. Symptoms of low potassium can include a number of those listed above, and very occasionally this may be severe.
Most of these side effects are mild when they occur. Do not be alarmed by this list of possible side effects. You may not experience any of them. However, if you do, or if you notice anything else that is making you feel unwell, you should consult your doctor or pharmacist.
If any of the signs below occur then tell your doctor immediately or go to the Accident and Emergency department at your nearest hospital. These side effects are extremely rare but can become serious.
- Swelling of your lips, face, mouth, tongue or throat.
- Purple spots with occasional blisters on the front of your arms and legs and/or around your neck and ears (a rare condition known as Stevens-Johnson Syndrome).
- A fast and irregular heart beat.
- Severe blisters, skin rash, itching or other allergic reactions.
After taking INDOSYL COMBI 4/1.25
Keep your INDOSYL COMBI 4/1.25 tablets where children cannot reach them. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
Keep your tablets in the pack until it is time to take them. INDOSYL COMBI 4/1.25 will not keep as well outside its blister packaging.
Heat and dampness can destroy some medicines. Keep them in a cool, dry place where the temperature stays below 30 degrees C. Do not store medicines in a bathroom or near a sink. Do not leave them in a car or on a windowsill.
If your doctor tells you to stop taking INDOSYL COMBI 4/1.25, or the tablets have passed their expiry date, return any leftover tablets to your pharmacist for disposal.
What INDOSYL COMBI 4/1.25 looks like
INDOSYL COMBI 4/1.25 tablets are white and rod shaped.
INDOSYL COMBI 4/1.25 tablets come in a blister strip. Each box contains 30 tablets.
Each tablet of INDOSYL COMBI 4/1.25 contains 4mg of perindopril erbumine and 1.25mg of indapamide hemihydrate as active ingredients.
The inactive ingredients in INDOSYL COMBI 4/1.25 tablets include microcrystalline cellulose, lactose, magnesium stearate, and colloidal anhydrous silica.
The tablets are gluten free.
INDOSYL COMBI 4/1.25 is distributed in Australia by:
Aspen Pharma Pty Ltd
34-36 Chandos Street
St Leonards NSW 2065
INDOSYL COMBI 4/1.25 is registered on the Australian Register of Therapeutic Goods. Australian Register Number: AUST R 74137
This leaflet was last revised in August 2012
CMI provided by MIMS Australia, March 2015