Lucassin Powder for injection

Lucassin Powder for injection is a brand of medicine containing the active ingredient terlipressin.

Find out more about active ingredients.

Consumer medicine information (CMI) leaflet

Developed by the pharmaceutical company responsible for this medicine in Australia, according to TGA regulations.


Terlipressin 0.85 mg powder for injection

Consumer Medicine Information

What is in this leaflet?

This leaflet answers some common questions about LUCASSIN. It does not contain all of the available information. It does not take the place of talking to your doctor, nurse or pharmacist.

All medicines have risks and benefits. Your doctor has weighed the expected benefits of you having LUCASSIN against the risks this medicine could have for you.

If you have any concerns about this medicine, ask your doctor, nurse or pharmacist.

Keep this leaflet. You may need to read it again.

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What is LUCASSIN used for?

This medicine is used to treat hepatorenal syndrome, type 1 (HRS-1). LUCASSIN is given when a patient with HRS-1 is being considered for a liver transplant. HRS-1 is a condition in which the kidneys suddenly fail to work in a person with severe liver disease. HRS-1 is a life-threatening complication of severe liver disease. The cause of HRS-1 is not fully understood. It is thought to be due to the kidneys drastically reducing their own blood flow, in response to large changes in blood flow in other parts of the body caused by severe liver disease.

LUCASSIN works by improving blood flow in the kidneys.

Your doctor may have prescribed LUCASSIN for another reason. Ask your doctor if you have any questions about why LUCASSIN has been prescribed for you.

LUCASSIN is only available with a doctor’s prescription.

LUCASSIN is not addictive.

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Before you are treated with LUCASSIN

Things to be aware of before you are treated with LUCASSIN include:

LUCASSIN should not be used in patients who have had an allergic reaction to terlipressin or any of the ingredients listed toward the end of this leaflet. (See “Ingredients”).

Use in pregnancy

LUCASSIN is not recommended for use in women who are pregnant or intend to become pregnant. If there is a need to consider using LUCASSIN during your pregnancy, your doctor will discuss with you the benefits and risks of using it.

Use in children

The safety and effectiveness of LUCASSIN in children have not been established.

If you are not sure whether you should have LUCASSIN, talk to your doctor, nurse or pharmacist.

Tell your doctor if:

You must tell your doctor if:

  • You are allergic to foods, dyes, preservatives or any other medicines.
  • You have ever had a heart attack or a history of heart problems.
  • You have asthma, chronic bronchitis, emphysema or a history of lung problems.
  • You are breast-feeding or intending to breast-feed.
  • You are taking any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food shop.

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How LUCASSIN is used

LUCASSIN is given as an injection, usually through an intravenous line, by a doctor or nurse.

Before LUCASSIN is used, it must be dissolved in sterile normal saline solution. LUCASSIN should not be mixed with dextrose solution for injection.

How much to use

Treatment with LUCASSIN is carried out in a hospital. You will not be taking the medicine by yourself. Instead, the medicine will be given to you as an injection by your doctor or nurse. The usual starting dose is one vial (0.85 mg terlipressin) injected into the vein every 6 hours. Your doctor may adjust the dose depending on how you are responding to the treatment.

How long to use it for

LUCASSIN is generally used for up to two weeks or less in treating an occurrence of HRS-1.

If you take too much (overdose)

As LUCASSIN will be given to you directly by your doctor or nurse in a hospital, it is unlikely that you will receive too much.

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What are the side effects?

Tell your doctor or nurse as soon as possible if you experience any problems after having LUCASSIN, even if the problems are not listed in this leaflet. Like all medicines, LUCASSIN can cause side effects, although not everybody gets them. Sometimes the side effects can be serious, although most of the time they are not.

The hospital staff will be monitoring you for possible side effects. If you get some of the side effects, your doctor and/or nurse will help you manage them while you are in the hospital.

Ask your doctor, nurse or pharmacist to answer any questions you may have.

Don’t be alarmed by the following list of side effects. You may not experience any of them.

Tell your doctor or nurse AT ONCE if you experience any of the following while you are receiving LUCASSIN:

  • Allergic reaction which can occur as skin rash; unusual wheezing or difficulty with breathing; swollen eyelids, lips or tongue; pain in muscles or joints; light-headedness or fainting.
  • Chest pain or tightness.
  • Any unusual feeling in your heart including irregular, fast or slow heart beat.
  • Stomach pain.
  • Passing out red or dark-coloured stool during bowel movement.
  • Pain in your hands or feet.
  • Skin turning blue or purple.
  • Shortness of breath, wheezing or trouble with breathing.
  • Feeling or being sick (nausea or vomiting).
  • Diarrhoea.
  • Swelling due to excess fluid in the body.
  • Tingling or numbness of the hands or feet.
  • Reddening and pain at the injection site.

This is not a complete list of all possible side effects. Others may occur in some people receiving LUCASSIN; and there may be some side effects not yet known.

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LUCASSIN is usually stored in the hospital pharmacy or in the hospital ward. It requires refrigeration between 2°C and 8°C.

After dissolving LUCASSIN in sterile normal saline, the solution may be refrigerated (2 - 8°C) for up to 24 hours before use.

Do not freeze. Prior to use, vials should be stored in original carton in order to protect from light.

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Product description

What LUCASSIN looks like

LUCASSIN is a sterile white to off-white powder supplied in single use vials. Each vial contains 0.85 mg terlipressin.

LUCASSIN is supplied as single vials, and also in packs of 12 vials.


LUCASSIN contains the active ingredient, terlipressin, and an inactive ingredient, mannitol. It may also contain acetic acid and/or sodium hydroxide.

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CMI provided by MIMS Australia, June 2013  

Related information - Lucassin Powder for injection


16 Sep 2015 Information on medicines available in Australia containing terlipressin, including our latest evidence-based information and resources for health professionals and consumers. The active ingredient is the chemical in a medicine that makes it work. Medicines that contain the same active ingredient can be available under more than one brand name. Brands include both active ingredients and inactive ingredients. You'll find information about brands of medicines that contain terlipressin below, including their consumer medicine information (CMI) leaflets.