Interactions with amoxycillin and clavulanic acid

What are the interactions with amoxycillin with clavulanic acid?

Tell your doctor about all the medicines you are taking

It is important that you tell your health professional about all the medicines you or anyone in your care is taking — including prescription, over-the-counter and complementary medicines (herbal, ‘natural’, vitamin and mineral supplements). This is because all medicines, including herbal and natural medicines, can cause side effects and may interact with other medicines.

Tell your doctor if you are taking:

  • allopurinol or probenecid (medicines used to treat gout): if you are taking allopurinol or probenecid there is an increased chance that you will develop a rash if you are also taking amoxycillin.

Medicinewise tip

To check if your medicine contains these active ingredients, look on the packaging of your medicine for the active ingredient name, or use our Medicines Finder.

Can I drink alcohol if I am taking amoxycillin with clavulanic acid?

Drinking alcohol in moderation is unlikely to interact with amoxycillin with clavulanic acid, or to cause additional side effects.

Find out more about drinking alcohol when you are taking antibiotics.

Will amoxycillin with clavulanic acid affect my contraceptive?

Amoxycillin with clavulanic acid won’t affect your contraceptive.

Rifampicin-like antibiotics (e.g. rifampicin and rifabutin) are the only types of antibiotic that are known to interact with hormone contraceptives, such as the combined contraceptive pill, making it less effective.

Find out more about antibiotics and contraception.

Phone for medicines information

Call NPS Medicines Line on 1300 MEDICINE (1300 633 424) to get information about your prescription, over-the-counter and complementary medicines (herbal, ‘natural’, vitamins and mineral supplements) from a pharmacist. Your call will be answered by healthdirect Australia (except Queensland and Victoria).

  • Rossi S, ed. Australian Medicines Handbook [online]. Adelaide: AMH, January 2012.
  • Sweetman S, ed. Martindale: The complete drug reference [online]. London: Pharmaceutical Press (accessed 18 October 2011).
  • Antibiotic Expert Group. Therapeutic Guidelines: Antibiotic version 14; Amoxycillin plus clavulanate. Melbourne: Therapeutic Guidelines Limited, 2012 (accessed 24 February2012).