Interactions with roxithromycin

What are the interactions with roxithromycin?

Tell your doctor about all the medicines you are taking.

It is important that you tell your health professional about all the medicines you are taking — including prescription, over-the-counter and complementary medicines (herbal,’natural’, and vitamin and mineral supplements). This is because all medicines, including herbal and natural medicines, can cause side effects and may interact with roxithromycin.

Tell your health professional if you are taking medicines containing any of these active ingredients.

  • Cabergoline (used to treat Parkinson’s disease): roxithromycin may increase the amount of cabergoline in the blood. This may increase the effect of the medicines and increase the chance of side effects. You may need to take a lower dose of cabergoline.
  • Midazolam (used as a sedative during short medical procedures): roxithromycin may increase the concentration of midozalam in the blood and increase its sedative and other side effects. You may need to take a lower dose of midazolam or a different sedative.
  • Warfarin (used to prevent blood clots): roxithromycin may affect the way warfarin is taken up by the body, increasing the risk of bleeding. You may need to take another type of antibiotic. Alternatively, your doctor will monitor your blood clotting, and your dose of warfarin may need to be adjusted accordingly.

Medicinewise tip

To check if your medicine contains this active ingredient, look on the packaging of your medicine for the active ingredient name, or use our Medicines Finder.

Can I drink alcohol if I am taking roxithromycin?

Drinking alcohol in moderation is unlikely to interact with roxithromycin or cause additional side effects.

Find out more about drinking alcohol when you are taking antibiotics.

Will roxithromycin affect my contraceptive?

Roxithromycin won’t affect your hormone contraceptive.

Rifampicin and rifabutin are the only types of antibiotic that are known to interact with some forms of hormone contraceptives, such as the combined contraceptive pill, making it less effective.

Find out more about antibiotics and contraception.

Phone for medicines information

Call NPS Medicines Line on 1300 MEDICINE (1300 633 424) to get information about your prescription, over-the-counter and complementary medicines (herbal, ‘natural’, vitamins and mineral supplements) from a pharmacist. Your call will be answered by healthdirect Australia.

  • Rossi S, ed. Australian Medicines Handbook [online]. Adelaide: AMH, July 2012.
  • Sweetman S, ed. Martindale: The complete drug reference [online]. London: Pharmaceutical Press (accessed 18 October 2011).
  • Antibiotic Expert Group. Therapeutic Guidelines: Antibiotic version 14; Roxithromycin. Melbourne: Therapeutic Guidelines Limited, 2012 (accessed 27 March 2012).