What are the side effects of roxithromycin?

It is important to tell your health professional about any medicines you may be taking, or if you have any current illness, allergies or long-term health conditions. This will help them decide if roxithromycin is suitable for you.

Side effects of roxithromycin

(1 to 10 in 100 people)
(fewer than 1 in 100 people)
(fewer than 1 in 1000 people at high doses)
Nausea or vomiting
Stomach pain and cramps
Thrush (candida infection)
Allergic reactions (e.g. anaphylactic shock)
Clostridium difficile-associated disease
Liver abnormalities (cholestatic hepatitis)
Inflamed pancreas (pancreatitis)
Ear problems (hearing loss, dizziness, noises or ringing in the ears or head [tinnitus])
Slowed heart rate
Blood problems (e.g. low numbers of cells that help blood to clot [thrombocytopenia])
Note: this is not a complete list of all the possible side effects of roxithromycin.

Heart problems

Roxithromycin can affect your heart rate, so you must tell your doctor if you have any heart problems (e.g. irregular heart beat or arrhythmia).

Antibiotics and allergic reactions

Some people experience an allergic reaction to roxithromycin or other antibiotics. This is due to an over-reaction of their immune system to the antibiotic.

Symptoms of an allergic reaction can include:

  • hives (large, red raised areas on the skin)
  • swollen lips, tongue or mouth
  • fever (a temperature of 38.5°C or higher)
  • breathing problems
  • fainting.

Seek medical advice if you experience any of these symptoms while you are taking an antibiotic.

It is not known why this happens to some people and not others, but it may mean that you will have to avoid taking the antibiotic in the future. There are other types of antibiotics which don’t cause this reaction that will be suitable for you.

Read more about the common side effects of antibiotics.

Who can I ask about side effects?

If you’re concerned that you or someone in your care may have had side effects related to a medicine, seek medical advice. People with questions about their medicines or seeking general information about side effects can also call the NPS Medicines Line on 1300 633 424 (Monday-Friday, 9am-5pm AEST). To report possible side effects call the Adverse Medicine Events (AME) line on 1300 134 237 from anywhere in Australia (Monday–Friday, 9am–5pm AEST).

  • Rossi S, ed. Australian Medicines Handbook [online]. Adelaide: AMH, July 2012.
  • Sweetman S, ed. Martindale: The complete drug reference [online]. London: Pharmaceutical Press (accessed 18 October 2011).
  • Antibiotic Expert Group. Therapeutic Guidelines: Antibiotic version 14; Roxithromycin. Melbourne: Therapeutic Guidelines Limited, 2012 (accessed 27 March 2012).