Interactions with aspirin

It’s important that you tell your health professional about all the medicines you are taking — including prescription, over-the-counter and complementary (herbal, ‘natural’, vitamins or mineral supplements) medicines — as they may interact with ibuprofen.

Keep a list of all your medicines and take it with you when you visit the doctor or pharmacist.

The following medicines may interact with aspirin:

  • corticosteroids — taken at high doses these can decrease the amount of aspirin in the blood. They can also increase the risk of stomach problems including bleeding.
  • other NSAIDs: aspirin increases the risk of stomach ulcers and bleeding if it is taken with other NSAIDs — even at low doses.
  • probenecid (used to treat gout) — low-dose aspirin won’t have an effect, but regular use of high doses of aspirin may make probenecid less effective.
  • valproate (prevents seizures) — low-dose aspirin won’t have an effect, but high doses of aspirin can increase the concentration of valproate in the blood, so you may need a lower dose of valproate. Valproate can increase the risk of bleeding if you are also taking aspirin.
  • warfarin (prevents blood clots) — aspirin can increase the risk of bleeding.

Always check with your doctor or pharmacist about whether your medicines are safe to take with aspirin. You can also read the consumer medicines information (CMI) leaflet for your medicine (if available).

Phone for medicines information

Call NPS Medicines Line on 1300 MEDICINE (1300 633 424) to get information about your prescription, over-the-counter and complementary medicines (herbal, ‘natural’, vitamins and mineral supplements) from a pharmacist. Your call will be answered by healthdirect Australia (except Queensland and Victoria).

Find out more about aspirin, who can take aspirin and the side effects of aspirin.