Interactions with paracetamol

It’s important that you tell your health professional about all the medicines you are taking — including prescription, over-the-counter and complementary (herbal, ‘natural’, vitamins or mineral supplements) medicines — as they may interact with paracetamol.

Keep a list of all your medicines and take it with you when you visit the doctor or pharmacist.

Paracetamol may interact with the following medicines:

  • warfarin (Coumadin, Marevan) (used to prevent blood clotting). If you start taking more than 3.5 g of paracetamol per week regularly, this can affect your blood clotting, and your doctor may need to adjust your dose of warfarin; though this is not thought to happen if you take occasional doses of paracetamol.
  • some medicines for epilepsy (e.g. carbamazepine, brand names Tegretol, Teril) and phenytoin (e.g. Dilantin).

Check whether your medicines are safe to take with paracetamol by asking your doctor or pharmacist or by reading the consumer medicines information (CMI) leaflet for your medicine if available.

Find out more about paracetamol, who can take paracetamol and the side effects of paracetamol.