Rivaroxaban (Xarelto) for preventing blood clots after hip or knee replacement surgery

Published in Medicine Update

Date published: About this date

Health and medicines information in this article may have changed since the date published. This information does not replace advice from a health professional.

This Medicine Update is for people who have been prescribed rivaroxaban to prevent a blood clot after hip or knee replacement surgery.


Rivaroxaban is a new medicine to prevent blood clots forming after hip or knee replacement surgery. It works by thinning the blood.

Rivaroxaban is available as tablets. It is important that you take one rivaroxaban tablet every day for the prescribed number of days.

Rivaroxaban appears to be as safe and effective as other blood thinning medicines but, as with these other medicines, you need to be aware of the signs of bleeding.


What rivaroxaban is

The active ingredient of this medicine is rivaroxaban (pronounced riv-ah-ROCKS-a-ban). It is also known by the brand name Xarelto.

What rivaroxaban is for

Rivaroxaban is used to prevent blood clots forming in the leg veins after hip or knee replacement surgery. The medical term for these blood clots is deep vein thrombosis (DVT).

A blood clot in the legs can travel through the bloodstream to the lungs, where it can block an artery. This is a serious condition known as a pulmonary embolism. It may be life threatening.

Who can take rivaroxaban

People can be prescribed rivaroxaban through the Pharmaceutical Benefits Scheme (PBS) to prevent blood clots forming after hip or knee replacement surgery.

You may be given another medicine instead to prevent blood clots (see Other medicines available).

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When to take rivaroxaban

You will usually be given this medicine 6 to 10 hours after surgery. You will need to continue taking it every day for the prescribed number of days.

Rivaroxaban must be taken each day at about the same time for:

  • 35 days following a hip replacement
  • 14 days following a knee replacement.

You may be given enough rivaroxaban tablets to complete your course of treatment when you leave hospital.

Other hospitals will give you only a small supply of rivaroxaban tablets and you will need to either:

  • visit your GP to get a prescription to complete your course, or
  • visit your local pharmacist to fill the rivaroxaban prescription given to you in hospital.

It is important that you do not accidentally take rivaroxaban tablets from the hospital and rivaroxaban tablets you get from your GP or pharmacist at the same time.

Finish the rivaroxaban tablets from the hospital before you start taking the tablets from your GP or pharmacist.

Make sure you tell your GP or pharmacist the date of your surgery and ask them the date when you should stop taking the tablets. Write this date on the box and do not take any rivaroxaban tablets after this date.

How to take rivaroxaban

Always take rivaroxaban exactly as prescribed.

The daily dose is one 10 milligram tablet.

You should take the tablet at about the same time each day. Swallow it whole with water. It can be taken with or without food.

If you forget to take a rivaroxaban tablet, do not take a double dose the next day because this will increase the risk of bleeding.

Important side effects of rivaroxaban to consider

Ask your health professional about the possible side effects of this medicine before you take it. Always tell them about any changes to your condition if you're taking a new medicine.

To report possible side effects call the NPS Adverse Medicine Events (AME) Line on 1300 134 237 from anywhere in Australia (Monday–Friday, 9am–5pm AEST).

People with questions about their medicines or seeking general information about side effects can call the NPS Medicines Line on 1300 633 424 (Monday–Friday, 9am–5pm AEST).

For rivaroxaban and other blood thinning medicines, the main risk is bleeding.

You may find that some blood seeps through the dressing after your operation. Some seepage is normal, but if you think that the bleeding is excessive speak to your doctor about it.

You should seek urgent medical attention if you have:

  • bleeding that won’t stop
  • nosebleeds that last for longer than 10 minutes
  • unexplained or severe bruising.

Internal bleeding is harder to detect, but can be very serious. If you experience any of the following, contact your doctor immediately or go to the emergency department at your nearest hospital:

  • blood in your urine
  • red or black faeces
  • headaches that are unusual for you.

If you experience any serious injury, you are at greater risk of internal bleeding. You must get immediate medical attention, particularly if you hit your head.

For a more complete list of possible side effects for Xarelto  (rivaroxaban), see the consumer medicine information (CMI) leaflet available on our Medicines search page.

Rivaroxaban has been tested in clinical trials, but it is a new medicine so the full range of side effects is not known. You should be aware of this and see your doctor straight away if you have any concerns.

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What else you should know about rivaroxaban

If you stop taking rivaroxaban too early you are at greater risk of developing a blood clot in the veins of your leg. Make sure that you take it for the number of days that your doctor, pharmacist or nurse has told you.

While you are taking rivaroxaban, you should talk to your doctor before taking other medicines that can increase your risk of bleeding. These include:

  • aspirin
  • medicines that reduce pain and inflammation like:
    • ibuprofen (Advil, Brufen, Nurofen, Rafen)
    • diclofenac (Fenac, Voltaren)
    • naproxen (Naprogesic, Naproleve, Naprosyn, Proxen).

If you have a mild headache or other pain, or fever associated with a cold, you may use paracetamol (Panadol, Panamax).

Some other medicines can interact with rivaroxaban. You should talk to your doctor before taking any other medicine from a pharmacy, supermarket or health food store.

Use a medicines list to help keep track of the medicines you are taking. Take it with you each time you visit a health professional, or if you go into hospital.

Get an NPS Medicines List or download the free iPhone app.

Your hospital doctor will consider any other health problems you might have before prescribing rivaroxaban for you.

Rivaroxaban may not be suitable for you if you have:

  • severely reduced kidney function
  • severe liver disease
  • had a stroke in the previous 6 months
  • very high blood pressure
  • a medical condition that increases your risk of bleeding.

Other medicines available

Some medicines to prevent blood clots after hip or knee replacement surgery are given as a daily injection. They include dalteparin (Fragmin), enoxaparin (Clexane) and fondaparinux (Arixtra).

Rivaroxaban is a new blood thinning (anticoagulant) medicine that is available in tablet form. Another new anticoagulant — called dabigatran (Pradaxa) — is available as a capsule that you swallow. These two medicines work in slightly different ways, but in clinical trials both were found to be about as effective as a daily injection of enoxaparin. The risk of bleeding was also similar.

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What does rivaroxaban cost?

If you get rivaroxaban through the Pharmaceutical Benefits Scheme (PBS), the Australian Government pays most of the cost and you will pay only a part, called the co-payment. for more information see pbs.gov.au.

The full cost of rivaroxaban to the Australian Government varies depending on the size of the pack:

  • $148.66 for 10 mg rivaroxaban tablets (pack size 15 tablets)
  • $279.89 for 10 mg rivaroxaban tablets (pack size 30 tablets).

At the time of publication, the co-payment for people who are entitled to get rivaroxaban through the PBS was:

  • $33.30 for people without a concession card
  • $5.40 for concession card holders.

If you are not eligible to get rivaroxaban through the PBS, you will need to pay the full price for a prescription.

Other ways to prevent blood clots

In addition to taking an anticoagulant medicine such as rivaroxaban, you should wear compression stockings while you are recovering from hip or knee replacement surgery. These further reduce your risk of blood clots.

You will also be given a program of exercises to help with your recovery.

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Where to find more information about rivaroxaban

You can find more information in the consumer medicine information (CMI). This will tell you:

  • who should not use the medicine
  • which other medicines should be avoided
  • how to take the medicine
  • most of the possible side effects
  • the ingredients.

You can get the CMI leaflet for Xarelto from:

  • your doctor or pharmacist
  • our Medicines Finder page
  • Bayer, the makers of Xarelto (rivaroxaban), on 1800 672 270.

Information over the phone

NPS works with healthdirect Australia to provide the Medicines Line phone service for consumers.

To get more information about any medicine call 1300 MEDICINE (1300 633 424). This service is available from anywhere in Australia, Monday to Friday, 9am to 5pm AEST excluding NSW public holidays.

To report a side effect

Call the NPS Adverse Medicine Events (AME) Line on 1300 134 237, Monday to Friday, 9am to 5pm AEST excluding public holidays.

The AME Line is a service where you can report possible side effects of your medicine and contribute to national medicine safety efforts. Information on medicine-related side effects is passed on to the Therapeutic Goods Administration (TGA) for assessment, but your personal details will remain confidential and your privacy maintained.

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