Be aware: perindopril + amlodipine PBS listing differs from label
Published in Health News and Evidence
Date published: About this date
Clinical content may change after this date. This information is not intended as a substitute for medical advice from a qualified health professional. Health professionals should rely on their own expertise and enquiries when providing medical advice or treatment.
A potential for confusion may arise when prescribing fixed dose combination (FDC) products containing perindopril and amlodipine (Coveram and Reaptan) due to a discrepancy in the order in which the components appear in the PBS listing compared with the manufacturer’s labelling.
These FDC products were first listed on the PBS in June 2010 with the perindopril component listed first, and the current Product Information and label for each also list the components in this order.1,2 However the PBS listing was changed in December 2012 to reflect the preferred name under the Australian Medicines Terminology (AMT) i.e. amlodipine+perindopril.3
These products are available in four strength combinations of perindopril/amlodipine: 5mg/5mg, 5mg/10mg, 10mg/5mg, 10mg/10mg. Potential for confusion arises especially when prescribing and dispensing the 5mg/10mg and 10mg/5mg combinations and caution is required to ensure the intended combination is accurately prescribed and dispensed.
Coveram and Reaptan are PBS listed as substitution therapy for the treatment of hypertension in a patient who is not adequately controlled with either of the drugs in the combination and/or stable coronary heart disease in a patient who is stabilised on treatment with perindopril and amlodipine at the same doses.3
- Servier Laboratories (Australia) Pty Ltd. Coveram (perindopril arginine/amlodipine besylate) Product Information. January 2013. 2013. https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2011-PI-02600-3 (accessed 6 May 2013).
- Servier Laboratories (Australia) Pty Ltd. Reaptan (perindopril arginine/amlodipine besylate) Product Information. January 2013. 2013. https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2011-PI-02422-3 (accessed 6 May, 2013).
- Australian Government Department of Health and Ageing. PBS listing for amlodipine + perindopril. 2013. http://www.pbs.gov.au/medicine/item/9346X-9347Y-9348B-9349C (accessed 6 May 2013).