NPS RADAR December 2011

Title Why read this
Asenapine Information about asenapine sublingual wafers (Saphris) for schizophrenia and acute and maintenance treatment of manic and mixed episodes in bipolar I disorder. Asenapine has a similar spectrum of benefits and harms to that of other antipsychotics.
Oxycodone with naloxone Information about oxycodone-with-naloxone controlled-release (CR) tablets (Targin) for chronic severe pain. The tablets provide equivalent analgesia to that of oxycodone CR tablets, with reduced opioid-induced constipation.
Indacaterol Information on indacaterol as a once-daily, maintenance bronchodilator treatment of airflow limitation in patients with chronic obstructive pulmonary disease (COPD).
Ticagrelor Ticagrelor (Brilinta) and aspirin reduces the incidence of vascular deaths and myocardial infarctions more than clopidogrel and aspirin, but this must be weighed against an increased risk of adverse events.
Brief item: losartan Generic losartan (Cozavan) was PBS listed on 1 December 2011. It is the first generic angiotensin II-receptor antagonist to be listed.
Brief item: budesonide with eformoterol Information on budesonide with eformoterol in treatment of moderate to severe chronic obstructive pulmonary disease in people with frequent symptoms despite long-acting bronchodilator use and/or a history of recurrent exacerbations.
Brief item: paliperidone Long-acting intramuscular injectable form of paliperidone (Invega Sustenna) for schizophrenia.
Brief item: dabigatran safety update The Therapeutic Goods Administration published a Safety Advisory on 3 November 2011 regarding the risk of bleeding in people using dabigatran.
NPS RADAR December 2011 NPS RADAR articles provide timely, independent, evidence-based assessment of new drugs, new PBS listings and research for health professionals.