NPS RADAR December 2006

Title Why read this
Amlodipine with atorvastatin (Caduet) for dyslipidaemia with concomitant hypertension or angina Reviews use of amlodipine/atorvastatin combination for concurrent dyslipidaemia, hypertension, and angina in comparison with use as single agent therapy.
Imiquimod cream (Aldara) for superficial basal cell carcinoma Reviews topical use of imiquimod for superficial basal cell carcinoma, including indications for use and comparison with other treatments.
Insulin glargine (Lantus) for type 1 and 2 diabetes mellitus Reviews use of insulin glargine for diabetes mellitus, including comparison with isophane insulin and risk of hypoglycemia.
Pimecrolimus (Elidel) cream for facial atopic dermatitis Reviews use of pimecrolimus cream for facial atopic dermatitis when topical corticosteroids are contraindicated.
Rosuvastatin (Crestor) for dyslipidaemia Reviews use of rosuvastatin for dyslipidaemia, including target LDL-C levels, dosage guidelines, and safety profile.
Brief item: Trastuzumab (Herceptin) PBS listed for early breast cancer Trastuzumab is listed on the PBS as an authority prescription for the initial and continuing treatment of HER2-positive early breast cancer, starting concurrently with adjuvant chemotherapy after surgical excision.
Brief item: Rosiglitazone with metformin combination tablets (Avandamet) listed on the PBS Rosiglitazone with metformin in a fixed-dose combination tablet (Avandamet) was listed on the PBS as a third-line choice, after metformin and/or a sulfonylurea.
Brief item: Exemestane (Aromasin) and letrozole (Femara) listings extended to early breast cancer in postmenopausal women The PBS restriction for exemestane and letrozole was extended to include adjuvant treatment of hormone-dependent early breast cancer in postmenopausal women.
Brief item: Hydroxocobalamin should be given every 2-3 months The maximum quantity of hydroxocobalamin has been increased from 2 to 3 ampoules, so that it may be given every 2-3 months for prevention of vitamin B12 deficiency.
Erratum: Fentanyl patches (Durogesic) for chronic pain Information about equi-analgesic doses of methadone have been removed from 'Table 1: Equipotency of opioid analgesics to oral morphine 30 mg', in the Dosing Issues section of this NPS RADAR review published in the August 2006 issue.
NPS RADAR December 2006 NPS RADAR articles provide timely, independent, evidence-based assessment of new drugs, new PBS listings and research for health professionals.