Definition of fixed-dose combination medicines

Combination medicines (or fixed-dose combination [FDC] medicines) are:

  • medicines containing two or more active components in fixed proportions in a single dosage form
  • several medications in fixed combination to be taken together, presented in composite packaging (co-pack).1

Examples of fixed-dose combination medicines2

Two or more medicines in single dosage form

Individual dosage forms in a co-pack

  • paracetamol 500 mg
  • pseudoephedrine hydrochloride 30 mg
  • codeine phosphate 6 mg

(Codral Original Cold & Flu tablets)

  • esomeprazole 20 mg
  • clarithromycin 500 mg
  • amoxycillin 500 mg

(Nexium Hp7 )

  • eformoterol 6 micrograms/dose
  • budesonide 200 micrograms/dose

(Symbicort 200/6 Turbuhaler)

  • alendronate 70 mg
  • cholecalciferol 140 micrograms
  • calcium 500 mg

(Fosamax Plus D-Cal)

For more information

References
  1. Australian Government Department of Health and Ageing. Compliance Medicines Working Group Report to Pharmaceutical Benefits Advisory Committee. April 2010. [Online] (accessed 11 December 2012).
  2. Australian medicines handbook. Adelaide: Australian Medicines Handbook Ltd, 2012.