The Editorial Executive Committee welcomes letters, which should be less than 250 words. Before a decision to publish is made, letters which refer to a published article may be sent to the author for a response. Any letter may be sent to an expert for comment. When letters are published, they are usually accompanied in the same issue by their responses or comments. The Committee screens out discourteous, inaccurate or libellous statements. The letters are sub-edited before publication. Authors are required to declare any conflicts of interest. The Committee's decision on publication is final.
Letter to the editor
Editor, -There has been some adverse publicity regarding the long-term use of nitrofurantoin. Some of my patients who require long-term prophylactic antibiotics, usually for urinary tract infection, are asking to come off this medication.
I find nitrofurantoin is a very useful antibiotic which is readily available (30 tablets with one repeat helps to ensure that patients do actually stay on it!). Nitrofurantoin is rapidly absorbed and rapidly excreted with high urinary concentrations and has good activity against Gram negative bacteria. It has a very low incidence of fungal problems especially vaginal candidiasis and a low incidence of gastrointestinal adverse effects.
It would be useful to know how these benefits can be weighed up against the risk of harm.