Prescribing by numbers
- Eve Hurley
- Aust Prescr 2000;23:38
- 1 February 2000
- DOI: 10.18773/austprescr.2000.038
The results of clinical studies are often presented in terms of the relative risk reduction achieved with an active treatment over a control. The relative risk reduction is usually expressed as a percentage and can appear impressive but, as it is isolated from the underlying incidence of the event being prevented, it has little value in the clinical situation.
Absolute risk reduction is the difference in event rates between active and control groups, but it can be difficult to visualise its clinical relevance. The reciprocal of the absolute risk reduction gives the number of patients who need to be treated to prevent one event. This is the number needed to treat and is a more useful measure which can be used to compare a range of interventions.1
The results of the Helsinki heart study2 (see box) were generally presented as a reduction of 34% in the incidence of coronary heart disease with gemfibrozil treatment.
Expressing results as the number of patients who need to be treated to prevent one event (or for one patient to benefit) is much more meaningful. It can be useful when discussing treatment options with patients.
Helsinki heart study
Subjects: 4081 asymptomatic men aged 40-55 with dyslipidaemia (total cholesterol minus HDL ≥5.2 mmol/L).
Treatment: gemfibrozil 600 mg twice daily (2051 men) or matched placebo (2030 men) in a five year
randomised double-blind study.
Results: number of events (fatal, non-fatal myocardial infarction or cardiac death)
gemfibrozil - 56 events, placebo - 84 events.
Senior Editor, Australian Medicines Handbook, Adelaide