Ulipristal

There are a few details concerning the new drug comment about ulipristal¹ that need to be clarified.

First, the copper intrauterine device is no longer the only option for emergency contraception after 72 hours as ulipristal is indicated for up to 120 hours after unprotected sex.

While the liver enzyme inducer interactions of ulipristal are mentioned, there is no mention that levonorgestrel emergency contraceptive pills have similar interactions.

There have been additional large postmarketing studies on pregnancy safety risks that are not mentioned in the comment, but would be useful for healthcare professionals to know about.²

Finally, the statement ‘it will be less effective if ovulation has already occurred’ differs from the Australian product information. This states, ‘if ovulation has already occurred, ulipristal is no longer effective’.

Philip Goldstone
Medical Director
Maries Stopes Australia
Melbourne