Autoimmune disorder occurs when the body's immune system attacks and destroys healthy body tissue by mistake. Examples associated with immune deficiencies include Crohn’s disease and ulcerative colitis.
Immunoglobulins, also known as antibodies, are protein molecules produced by plasma cells (white blood cells). They act as a critical part of the immune response by specifically recognising and binding to specific foreign substances, such as bacteria or viruses, and aiding in their destruction.
Immunoglobulin modulation therapy (IMT) is used to treat people with autoimmune and inflammatory conditions. This is where the immune system mistakenly attacks and destroys healthy tissue. IMT can help reduce the symptoms and change how these conditions develop, although how this works is not completely understood.
Immunoglobulin replacement therapy (IRT) is used to treat people who are unable to make enough of their own immunoglobulins, or whose immunoglobulins don’t work properly. Used in a number of primary and secondary immune deficiency disorders to help protect against infection and prevent long term damage from ongoing infections (such as chronic lung disease).
Intravenous immunoglobulin (IVIg) is a product made up of immunoglobulins (antibodies) that can be given intravenously (through a vein).
Primary immune deficiency disorders are a group of disorders caused by inherited or genetic defects in the cells and tissues of the immune system. These are grouped according to what part of the immune system is affected (such as the B cells or T cells).
Secondary immune deficiency disorders are more common than primary immune deficiency disorders. They can happen as a result of a person’s main medical condition, or because of damage to the immune system from environmental factors such as some cancer treatments. They are often resolved by treating the main medical condition.
Subcutaneous immunoglobulin therapy (SCIg) is a form of immunoglobulin treatment given by slowly injecting an immunoglobulin product into tissue just underneath the skin, usually on the abdomen or thigh.
Find out more about Immunoglobulins