December 2022 edition of Australian Prescriber out now

Administration of medicines to children: a practical guide

Giving medicines to infants and children can be a struggle, as parents and caregivers understand all too well. Pharmacist Lucinda Smith and colleagues from the Women’s and Children’s Hospital in Adelaide discuss practical techniques and strategies to improve palatability and acceptance of medicines by children. There is no ‘one-size-fits-all’ approach and often parents and caregivers may need to implement several strategies.

Coronary artery disease in women

Cardiovascular disease is the leading cause of death in women worldwide, yet it remains underdiagnosed and undertreated compared to the disease in men. Cardiologists Drs Natalie Montarello and Wai Ping (Alicia) Chan from Adelaide write about the sex-specific differences in cardiovascular disease assessment. Pregnancy history and early-onset menopause should be considered in addition to traditional risk factors.

Diuretics in the management of chronic heart failure: when and how

In heart failure management, priority should be given to medicines that reduce heart failure-related mortality, however diuretics are still important. Cardiology advanced trainee Dr Joseph Magdy and colleagues from the Prince of Wales Hospital in Sydney discuss the key role of diuretics in managing clinical congestion in heart failure.

Blood pressure elevations in hospital

Acute and asymptomatic in-hospital blood pressure elevations may not necessarily reflect poor pre-admission control of blood pressure requiring antihypertensives. Inappropriate use of these drugs can have harmful effects. Pharmacologist Dr Arduino Mangoni from Flinders University and colleagues review the evidence regarding the benefits of pharmacological treatment, highlighting the need for robust post-discharge assessments of blood pressure rather than routine drug treatment during hospitalisation.

Also in this issue:

Medicinal mishap – Osteonecrosis of the jaw and denosumab

A case of medication-related osteonecrosis of the jaw (presented by Emeritus Professor of Oral and Maxillofacial Surgery Alastair Goss from University of Adelaide) highlights the need to consider the timing of denosumab doses and to measure bone turnover for patients undergoing oral surgery.

Editorial – The end of NPS MedicineWise

Following the announcement that NPS MedicineWise will cease operations this month, former director Deborah Rigby reflects on the organisation’s achievements and the events leading up to its closure.

New drugs approved by the TGA: asciminib for chronic myeloid leukaemia, decitabine/cedazuridine for chronic myelomonocytic leukaemia and myelodysplastic syndromes, elasomeran/imelasomeran for prevention of COVID-19, mecasermin for primary insulin-like growth factor-1 deficiency, pemigatinib for cholangiocarcinoma, and selinexor for multiple myeloma.

 

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