Consumer medicine information

CMV Immunoglobulin-VF

Immunoglobulin, cytomegalovirus

BRAND INFORMATION

Brand name

CSL CMV Immunoglobulin-VF

Active ingredient

Immunoglobulin, cytomegalovirus

Schedule

What is in this leaflet

This leaflet answers some common questions about CMV Immunoglobulin-VF. The letters CMV stand for cytomegalovirus, a type of virus. It does not contain complete information about CMV Immunoglobulin-VF. It does not take the place of talking to your doctor.

If you have any concerns about using this medicine, ask your doctor. Follow your doctor’s advice even if it is different from what this leaflet says.

Please read this leaflet carefully and keep it for future reference.

The information in this leaflet is subject to change. Please check with your doctor whether there is any new information about this medicine that you should know since you were last treated.

What CMV Immunoglobulin-VF is used for

CMV Immunoglobulin-VF is manufactured from human plasma (the liquid component of blood) collected by Australian Red Cross Lifeblood. Donations are selected on the basis that they contain high levels of specific antibody to the cytomegalovirus. CMV Immunoglobulin-VF contains protein substances called antibodies, which can provide protection against cytomegalovirus infection. CMV Immunoglobulin-VF is used to prevent cytomegalovirus infection in specific transplant patients. It may also help in the treatment of cytomegalovirus infection.

Ask your doctor if you have any questions why CMV Immunoglobulin-VF has been prescribed for you. Your doctor will have assessed the risks and benefits associated with the use of this medicine for you.

Before you are given CMV Immunoglobulin-VF

Make sure you tell your doctor of any reasons you know of why you should not be given this medicine. Inform your doctor of your blood group, if known.

You must not be given this medicine if you have:

a history of allergy to human immunoglobulin products (allergic reactions may include skin rash, face swelling, wheezing or breathing difficulties) or previously been told you react to any of the ingredients in CMV Immunoglobulin-VF (human immunoglobulins or maltose)
been told you have antibodies to immunoglobulin A (IgA).

Tell your doctor if you have allergies to any other medicines or if you have ever had an allergic reaction to an injection.

Tell your doctor also if you:

have previously been advised that you have Immunoglobulin A (IgA) deficiency
have previously been advised that you have kidney disease
have a history of heart, or blood vessel disease, or blood clots, have thick blood, have been immobile for some time. Also tell the doctor what medicine you are using as some medicines, such as those that contain the hormone estrogen (for example, birth control pills), may increase your risk of developing a blood clot.
have previously been advised that you have diabetes
have blood group A, B or AB
are taking or using any other medicines. These include medicines bought from pharmacies, supermarkets and health food stores.
have any other medical conditions
are pregnant or breast-feeding
become pregnant during your treatment
have had any vaccination during the last two weeks.

Vaccinations: Please inform your doctor if you are planning to have a vaccination. CMV Immunoglobulin-VF may impair the effect of some virus vaccines such as measles, mumps, rubella and chicken pox for a period of at least 6 weeks, and up to 3 months. After receiving this medicine, a period of 3 months should be allowed before vaccination with some virus vaccines. In the case of measles vaccine, this effect may last for up to 1 year. Therefore, your vaccinating doctor should check the effectiveness of the measles vaccination.

If you want any further information, consult your doctor.

About blood products

When products are made from human blood and injected into you, it is possible that viruses or other substances could be present in the product and cause an illness. These could be viruses such as hepatitis, human immunodeficiency virus (HIV), or human parvovirus B19 and theoretically the Creutzfeldt-Jakob Disease (CJD) agent. There could also be other infectious agents, some of which may not yet have been discovered.

To reduce the risk of this happening, extra steps are taken when manufacturing this product. Strict controls are applied when selecting blood donors and donations. The product is specially treated to remove and kill certain viruses. These special treatments are considered effective against viruses known as enveloped viruses such as HIV, hepatitis B virus and hepatitis C virus, and non-enveloped viruses, such as hepatitis A virus and human parvovirus B19. Despite these measures, the risk of viral and other agent’s infectivity cannot be totally eliminated.

Vaccines are available against some of these viruses and your doctor will be able to help you decide whether it is worthwhile having any of those vaccines.

Please discuss the risks and benefits of this product with your doctor.

How to use CMV Immunoglobulin-VF

Your doctor will determine the dose(s) of CMV Immunoglobulin-VF that you are to receive. Your doctor will give you CMV Immunoglobulin-VF as an infusion, that is, an injection given slowly into the vein.

Side effects

Along with their intended effects, blood products occasionally cause unwanted effects, some of which can sometimes be serious. Individuals may react differently to similar doses of the same medicine. This applies to CMV Immunoglobulin-VF.

Severe allergic reactions to immunoglobulins are rare. Should a severe allergic reaction occur, the doctor will stop the infusion.

Unwanted effects which may occur include: stomach pain, headache, chest tightness, flushed or pale face, feeling hot, shortness of breath, non-itchy skin rash, itching, faintness, dizziness, nausea or vomiting, or a hot feeling or redness at the site of injection. Should any of these effects develop during infusion, the doctor will take appropriate action.

Some patients may develop delayed unwanted effects such as nausea, vomiting, chest pain, chills or shivering, dizziness or aching legs. These effects may occur after the infusion has stopped but usually within 24 hours.

A condition called Aseptic Meningitis Syndrome (AMS) has been reported to occur infrequently in association with infusions similar to CMV Immunoglobulin-VF. It usually begins within several hours to two days following treatment. The signs include severe headache, neck stiffness, drowsiness, fever, inability to stand bright light, painful eye movements, and nausea and vomiting, or a hot feeling or redness at the site of injection. The condition reverses without ill effects when treatment is stopped.

There have been reports that the kidneys may be affected with infusions similar to CMV Immunoglobulin-VF. These occurrences are extremely rare.

If you experience any of the mentioned effects or any other abnormal signs after treatment, contact your doctor immediately.

Contact your doctor immediately if you experience any of these symptoms at any time:

fever
loss of appetite
extreme tiredness
dizziness
paleness of skin
stomach pain
jaundice (yellow skin and eyes)
dark urine
joint pains
skin rashes
shortness of breath
chest pain
pain/tenderness, swelling/discolouration of an arm or leg
weakness or numbness on one side of the body.

Interference with glucose estimations

The maltose present in CMV Immunoglobulin-VF may interfere with some blood glucose measurements, resulting in the overestimation of blood glucose results. If this glucose measurement is used to guide treatment, hypoglycaemia may occur. Only certain glucose tests have been implicated, so when monitoring glucose levels consult your doctor to ensure that maltose does not interfere with the blood glucose reading of the test you are using.

If you want further information, or if you are worried about any other symptoms after the infusion, consult your doctor.

Overdose

There is no information available.

Storing CMV Immunoglobulin-VF

Store at 2°C to 8°C (Refrigerate. Do not freeze). Protect from light.

Do not use after the expiry date shown on the label.

Further information

CMV Immunoglobulin-VF can only be obtained on a doctor’s prescription. This leaflet does not contain the complete information about CMV Immunoglobulin-VF. If you require further information about CMV Immunoglobulin-VF and your treatment generally, or if you have any questions or are not sure about something in this leaflet, consult your doctor.

Product description

What it looks like

CMV Immunoglobulin-VF is a clear, colourless, non-viscous (not thick) solution. It is available in glass bottles.

Ingredients

In each vial of CMV Immunoglobulin-VF is a sterile solution containing 6% blood proteins of which at least 98% is immunoglobulins. It also contains 10% maltose (a sugar).

Manufacturer

CMV Immunoglobulin-VF is manufactured in Australia by:

CSL Behring (Australia) Pty Ltd
ABN 48 160 734 761
189–209 Camp Road
Broadmeadows VIC 3047
Australia

Distributor

Australian Red Cross Lifeblood

Date of revision

June 2021

Australian Register Number
AUST R 31810

Published by MIMS August 2021

BRAND INFORMATION

Brand name

CSL CMV Immunoglobulin-VF

Active ingredient

Immunoglobulin, cytomegalovirus

Schedule

Notes

Distributed by Australian Red Cross Lifeblood

1 Name of Medicine

Human Cytomegalovirus Immunoglobulin.

2 Qualitative and Quantitative Composition

CMV Immunoglobulin-VF is a sterile, preservative free solution containing 50-70 mg/mL human plasma protein of which at least 98% is immunoglobulin (mainly IgG), with a cytomegalovirus (CMV) immunoglobulin activity of 1.5 million units per vial. The content of CMV immunoglobulin is defined in terms of EIA (enzyme immunoassay) units. One unit is equivalent to the specified volume of a standard CMV immunoglobulin.
The distribution of the IgG subclasses closely resembles that found in normal human plasma (approximate mean ranges: 52.5-64.9% IgG₁, 29.0-42.2% IgG₂, 3.1-6.8% IgG₃, 0.4-1.2% IgG₄).
CMV Immunoglobulin-VF contains less than 0.5 mg/mL immunoglobulin A (IgA).
The pH value of the ready-to-use solution is 4.25.
CMV Immunoglobulin-VF is manufactured from human plasma collected by Australian Red Cross Lifeblood.
Isotonicity is achieved by the addition of 292 mmol/L maltose.

3 Pharmaceutical Form

Solution for intravenous infusion.

4 Clinical Particulars

4.1 Therapeutic Indications

CMV Immunoglobulin-VF is indicated for the prevention of CMV infection following bone marrow and renal transplants. Specifically, the product is indicated when the recipient is seronegative for CMV and receives a graft from a CMV positive donor.
CMV Immunoglobulin-VF may also be a helpful adjunct to therapy in patients with established CMV infection, e.g. CMV pneumonitis.

4.2 Dose and Method of Administration

Dosage.

Because there is currently no international standard for CMV Immunoglobulin-VF, recommended dosage remains empirical. For prophylactic use it is recommended that patients receive 25,000 units/kg on days -4, -2, on the day of transplantation (intra-operatively) and then weekly for a further two months.
For therapy, 50,000 units/kg should be given initially, repeated after 4 to 5 days and then every 10 to 14 days until clinical improvement occurs.
See Table 1 for dosing requirements. If the calculated quantity of CMV Immunoglobulin-VF required for patients weighing > 15 kg includes a fraction of a vial, then the higher whole number of vials should be administered.
Specifically, patients weighing ≤ 15 kg must be dosed based on their body weight (units/kg). Each vial of CMV Immunoglobulin-VF contains at least 20,000 units/mL of CMV immunoglobulin activity. The actual volume is stated on the label. If only a portion of the vial is used, discard the residual volume. Do not administer the whole vial. The volume and acid load should be considered if CMV Immunoglobulin-VF is administered to neonates.

Administration.

If the product appears to be turbid by transmitted light or contains any sediment it must not be used, and the vial should be returned to Australian Red Cross Lifeblood. The product does not contain an antimicrobial preservative. It must, therefore, be used immediately after opening the vial. Any unused solution must be discarded appropriately. Use in one patient on one occasion only. Do not use if the solution has been frozen.
CMV Immunoglobulin-VF must be administered intravenously only.
It is usual to gradually increase the infusion rate to the desired rate over the first 30 minutes, provided the patient’s vital signs are satisfactory at the lower rate. The infusion may be commenced at the rate of 1 mL per minute. After 15 minutes the rate may be gradually increased to a maximum of 3 to 4 mL per minute over a further 15 minutes.
CMV Immunoglobulin-VF may be infused undiluted. Allow the preparation to reach room temperature before infusing into the patient. Remove the dust cover from the top of the vial.
Apply a suitable antiseptic such as povidone-iodine or 70% ethanol to the exposed part of the rubber stopper and allow to dry.

Compatibility with other medicines.

If necessary, CMV Immunoglobulin-VF may be diluted with up to four times its volume of 0.9% saline or 5% glucose. No other medicine interactions or compatibilities have been evaluated. CMV Immunoglobulin-VF should be administered separately from other intravenous fluids or medications the patient is receiving.

4.3 Contraindications

CMV Immunoglobulin-VF is contraindicated in patients:
who have had a true anaphylactic reaction to the active substance or to any of the components of the product;
with IgA deficiency, unless they have been tested and shown not to have circulating anti-IgA antibodies, since these patients may experience severe reactions to the IgA which is present in trace amounts.

4.4 Special Warnings and Precautions for Use

Route of administration.

CMV Immunoglobulin-VF must be administered intravenously only. Other routes of administration have not been evaluated.

Hypersensitivity.

CMV Immunoglobulin-VF contains trace amounts of IgA which may provoke anaphylaxis in patients with anti-IgA antibodies, such as those with IgA deficiency.
Rarely, human CMV immunoglobulin can induce a precipitous fall in blood pressure with anaphylactic reaction, even in patients who had tolerated previous treatment with human CMV immunoglobulin. These reactions may be related to the rate of infusion. Accordingly, the infusion rate given (see Section 4.2 Dose and Method of Administration) should be closely followed at least until the physician has had sufficient experience with a given patient. In case of anaphylactic reaction, the infusion should be stopped immediately. The patient's vital signs should be monitored regularly and careful observation made for any symptoms throughout the entire infusion and for at least 20 minutes after administration. In the case of shock, treatment should follow the guidelines of shock therapy. Adrenaline (epinephrine), oxygen, antihistamine and steroids should be available for the treatment of acute anaphylactic reactions.

Acute renal failure.

There have been occasional reports of renal dysfunction and acute renal failure in patients receiving IVIG products. Patients at increased risk are those with pre-existing renal insufficiency, diabetes mellitus, age greater than 65 years, volume depletion, sepsis and monoclonal gammopathy, and those taking concomitant nephrotoxic medicines. The majority of such incidents have been associated with sucrose-containing products. While these reports of renal dysfunction and acute renal failure have been associated with the use of many of the licensed IVIG products containing various excipients such as sucrose, glucose and maltose, those containing sucrose as a stabiliser accounted for a disproportionate higher share of the total number. CMV Immunoglobulin-VF contains maltose but it does not contain sucrose.
The following precautions should be followed: patients should be adequately hydrated prior to the initiation of the IVIG infusion and the recommended dose should not be exceeded.
Renal function should be monitored in patients at increased risk of developing acute renal failure. If renal function deteriorates, discontinuation of IVIG should be considered. In patients at risk of acute renal failure, IVIg products should be administered at the minimum rate of infusion and dose possible based on clinical judgement.

Haemolytic anaemia.

IVIG products can contain blood group antibodies which may act as haemolysins and induce in vivo coating of red blood cells (RBC) with immunoglobulin, causing a positive direct antiglobulin reaction (Coombs' test) and, rarely, haemolysis. Haemolytic anaemia can develop subsequent to IVIG therapy due to enhanced RBC sequestration. The following risk factors are associated with the development of haemolysis high doses, non-O blood group, and underlying inflammatory state. IVIG recipients should be monitored for clinical signs and symptoms of haemolysis, particularly those patients at increased risk. If these occur, appropriate laboratory testing should be obtained and discontinuation of the IVIG treatment considered by the treating physician if haemolysis develops.

Aseptic meningitis syndrome.

Aseptic Meningitis Syndrome (AMS) has been reported to occur infrequently in association with human intravenous immunoglobulin (IVIG) treatment. The syndrome usually begins within several hours to two days following IVIG treatment. It is characterised by symptoms and signs including severe headache, nuchal rigidity, drowsiness, fever, photophobia, painful eye movements, and nausea and vomiting. Cerebrospinal fluid (CSF) studies are frequently positive with pleocytosis, predominantly from the granulocytic series, and elevated protein levels. Patients exhibiting such symptoms and signs should receive a thorough neurological examination, including CSF studies, to rule out other causes of meningitis. AMS may occur more frequently in association with high dose (2 g/kg) IVIG treatment. Discontinuation of IVIg treatment has resulted in remission of AMS within several days without sequelae.

Thromboembolic events.

There is clinical evidence of an association between IVIG administration and thromboembolic events which is assumed to be related to a relative increase in blood viscosity through the high influx of immunoglobulin in at-risk patients. Caution should be exercised when prescribing and infusing IVIG for patients with pre-existing risk factors for thromboembolic events such as advanced age, estrogen use, in-dwelling vascular catheters, a history of venous or arterial thrombosis, acquired or inherited hypercoagulable states, cardiovascular risk factors (including history of atherosclerosis and/or impaired cardiac output), prolonged periods of immobilisation, severe hypovolaemia, hyperviscosity (including cryoglobulins, fasting chylomicronemia and/or hypertriglyceridaemia, and monoclonal gammopathies).
Reports have included cases of thrombophlebitis. In case of thromboembolic adverse reaction, the benefit and risk of treatment should be assessed before IVIG therapy is continued.
Patients at risk for thromboembolic adverse reactions should receive IVIG products at the minimum rate of infusion and dose possible based on clinical judgement and should be monitored for thromboembolic complications. Consideration should also be given to measurement of baseline blood viscosity in individuals at risk for hyperviscosity.

Pathogen safety.

This product is made from human plasma. Products made from human plasma may contain infectious agents, such as viruses and theoretically Creutzfeldt-Jakob Disease (CJD) agents that can cause disease. The risk that such products will transmit an infectious agent has been reduced by screening plasma donors for prior exposure to certain infectious agents and by testing for the presence of certain viral markers.
In addition, the manufacturing process for CMV Immunoglobulin-VF contains specific steps to reduce the possibility of viral transmission including low pH incubation for viral inactivation and nanofiltration for virus removal. The current procedures applied in the manufacture of this product are effective against enveloped viruses such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), and the non-enveloped viruses, such as hepatitis A virus (HAV) and human parvovirus B19.
There is reassuring clinical experience regarding the lack of parvovirus B19 transmission with immunoglobulins and the nanofiltration step of the manufacturing process has been shown to remove such viruses (or viruses of similar size). The product is known to contain antibodies to the virus.
Immunoglobulins for intravenous infusion, prepared by this process have not been implicated in the transmission of human immunodeficiency virus (HIV). Studies using plasma spiked with HIV have shown that the Cohn cold-ethanol fractionation process produces a very large reduction in virus titre with undetectable levels in the immunoglobulin fraction. Studies have shown that incubation at 27°C and pH 4.25, as performed in the manufacture of this product, also produces a very large reduction in HIV titre. Epidemiological studies have not recognised any cluster of AIDS patients or HIV seroconversion in immunoglobulin recipients.
Despite these measures, such products may still potentially transmit disease. There is also the possibility that other known or unknown infectious agents may be present in such products.
Vaccination should be considered where appropriate, for patients in receipt of medicinal products manufactured from human plasma.
It is strongly recommended that every time that CMV Immunoglobulin-VF is administered to a patient, the name and batch number of the product are recorded in order to maintain a link between the patient and the batch of the product.

Acid load.

In patients with limited or compromised acid-base compensatory mechanisms including neonates, consideration should be given to the effect of the additional acid load that the preparation might present.

Use in the elderly.

The use of this product in the elderly population has not been established in appropriate studies. To date, this population is not over-represented in spontaneous reports of adverse events associated with the use of CSL's IVIG therapeutic medicines.

Paediatric use.

The use of this product in the paediatric population has not been established in appropriate studies. To date, this population is not over-represented in spontaneous reports of adverse events associated with the use of CSL's IVIG therapeutic medicines.

Effects on laboratory tests.

After infusion of immunoglobulin, the transitory rise of the various passively transferred antibodies in the patient's blood may result in misleading positive results in serological testing. Passive transmission of antibodies to erythrocyte antigens (e.g. anti-A, anti-B, anti-D) may interfere with some serological tests for red cell allo-antibodies (e.g. Coombs’ test).

Interference with glucose estimations.

The maltose present in CMV Immunoglobulin-VF may interfere with some blood glucose measurements, resulting in the overestimation of blood glucose results. If this glucose measurement is used to guide treatment, hypoglycaemia may occur. Only certain glucose tests using glucose dehydrogenase have been implicated, so when monitoring glucose levels in patients receiving CMV Immunoglobulin-VF, information from the manufacturer of the glucose meter and/or test strips, should be reviewed to ensure that maltose does not interfere with the blood glucose reading.

4.5 Interactions with Other Medicines and Other Forms of Interactions

Live attenuated virus vaccines.

Passively acquired antibody can interfere with the response to live attenuated, virus vaccines. Therefore, administration of such vaccines, e.g. poliomyelitis or measles, should be deferred until approximately three months after passive immunisation.
In the case of measles, the decrease in efficacy may persist for up to one year. Therefore, patients receiving measles vaccine should have their antibody status checked. By the same token, immunoglobulins should not be administered for at least two weeks after a vaccine has been given.

4.6 Fertility, Pregnancy and Lactation

Effects on fertility.

No reproductive toxicity studies have been conducted with CMV Immunoglobulin-VF. There have been no reports of such effects associated with the use of CSL's plasma-derived therapeutic medicines.
The safety of CMV Immunoglobulin-VF for use in human pregnancy has not been established in controlled clinical trials and, therefore, it should be given to pregnant women only if clearly needed. However, clinical experience with other immunoglobulin preparations given during pregnancy suggests that there are no adverse effects on the foetus.
Immunoglobulins are excreted in breast milk and may contribute to the transfer of protective antibodies to the neonate. It is not known, however, whether this applies to passively administered CMV Immunoglobulin-VF. Clinical experience with immunoglobulins suggests that no harmful effects on the neonate are to be expected.

4.7 Effects on Ability to Drive and Use Machines

No effects on ability to drive and use machines have been observed.

4.8 Adverse Effects (Undesirable Effects)

Reactions to IVIG tend to be related to the infusion rate and are most likely to occur during the first hour of the infusion. It is recommended that the patient's vital signs and general status be monitored regularly throughout the infusion.
The types of reactions that may occur include: abdominal pain, headache, chest-tightness, facial flushing or pallor, feeling hot, dyspnoea, non-urticarial skin rash, itching, hypotension, nausea or vomiting. Should any of these reactions develop during infusion of CMV Immunoglobulin-VF, the infusion should be temporarily stopped until the patient improves clinically (5 to 10 minutes) and then cautiously recommenced at a slower rate.
Some patients may develop delayed adverse reactions to CMV Immunoglobulin-VF such as nausea, vomiting, chest pain, rigors or aching legs. These adverse reactions occur after the infusion has stopped but usually within 24 hours.
True anaphylactic reactions to IVIG such as urticaria, angioedema, bronchospasm or hypotension occur very rarely. Should an anaphylactic reaction to CMV Immunoglobulin-VF develop, the infusion should be stopped and treatment instituted with adrenaline (epinephrine), oxygen, antihistamine and steroids.
There have been reports that IVIG can affect renal function. This should be monitored in patients with pre-existing renal failure who are given CMV Immunoglobulin-VF.
Rarely, renal dysfunction and acute renal failure have been reported.

Reporting suspected adverse effects.

Reporting suspected adverse reactions after registration of the medicinal product is important. It allows continued monitoring of the benefit-risk balance of the medicinal product.
Healthcare professionals are asked to report any suspected adverse reactions at www.tga.gov.au/reporting-problems.

4.9 Overdose

Overdosage may lead to fluid overload and hyperviscosity, particularly in the elderly and in patients with cardiac or renal impairment.
For information on the management of overdose, contact the Poisons Information Centre on 13 11 26 (Australia).

5 Pharmacological Properties

5.1 Pharmacodynamic Properties

Mechanism of action.

Donations are selected on the basis that they contain high levels of specific antibodies to the CMV. The protein has not been chemically or enzymatically modified.

Clinical trials.

No data available.

5.2 Pharmacokinetic Properties

The serum half-life of CMV Immunoglobulin-VF is normally approximately three weeks, but may be shortened considerably in patients who are immunosuppressed.

5.3 Preclinical Safety Data

Genotoxicity.

No genotoxicity studies have been conducted with CMV Immunoglobulin-VF. There have been no reports of such effects associated with the use of CSL's plasma-derived therapeutic medicines.

Carcinogenicity.

No carcinogenicity studies have been conducted with CMV Immunoglobulin-VF. There have been no reports of such effects associated with the use of CSL's plasma-derived therapeutic medicines.

6 Pharmaceutical Particulars

6.1 List of Excipients

See Section 2 Qualitative and Quantitative Composition.

6.2 Incompatibilities

See Section 4.2 Dose and Method of Administration.

6.3 Shelf Life

In Australia, information on the shelf life can be found on the public summary of the Australian Register of Therapeutic Goods (ARTG). The expiry date can be found on the packaging.

6.4 Special Precautions for Storage

Store at 2°C to 8°C (Refrigerate. Do not freeze). Protect from light.
Do not use after the expiry date.

6.5 Nature and Contents of Container

CMV Immunoglobulin-VF is available in single vials each containing 1.5 million units of CMV immunoglobulin activity.

6.6 Special Precautions for Disposal

In Australia, any unused medicine or waste material should be disposed of in accordance with local requirements.

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Consumer medicine information

CMV Immunoglobulin-VF

Immunoglobulin, cytomegalovirus

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