- Brand name
- Venlafaxine AN SR Capsules
- Active ingredient
- Venlafaxine AN SR 150 mg Capsules
- Venlafaxine AN SR 37.5 mg Capsules
- Venlafaxine AN SR 75 mg Capsules
Consumer medicine information (CMI) leaflet
Please read this leaflet carefully before you start using Venlafaxine AN SR Capsules.Download CMI (PDF) Download large text CMI (PDF)
What is in this leaflet
This leaflet answers some common questions about Venlafaxine AN SR modified release capsules. It does not contain all the available information.
It does not take the place of talking to your doctor or pharmacist or asking questions.
All medicines have risks and benefits. Your doctor has weighed the risks of you taking Venlafaxine AN SR against the expected benefits it will have for you.
If you have any questions about Venlafaxine AN SR, ask your doctor or pharmacist.
Keep this leaflet with your Venlafaxine AN SR modified release capsules.
You may need to read it again.
What Venlafaxine AN SR is for
What it does
Venlafaxine AN SR modified release capsules are used in the treatment and prevention of relapse of depression and panic attacks and in the treatment of anxiety, including avoidance or fear of social situations.
Depression can affect your whole body and may cause emotional and physical symptoms such as feeling low in spirit, being unable to enjoy life, poor appetite or overeating, disturbed sleep, loss of sex drive, lack of energy and feeling guilty over nothing.
Excessive anxiety is a condition in which you feel constantly and uncontrollably worried and distressed. It may also make you feel irritable, and cause difficulty in thinking and sleeping. Other common symptoms associated with anxiety may include a dry mouth, a lump in the throat, cold clammy hands, diarrhoea and nausea.
Depression and anxiety are treatable illnesses. Anxiety or tension associated with the normal stress of everyday life usually does not require treatment with medicines.
How it works
Venlafaxine AN SR contains the active ingredient called venlafaxine hydrochloride. It belongs to a class of medications for depression and anxiety, called Serotonin-Noradrenaline Reuptake Inhibitors (SNRIs).
Serotonin and noradrenaline are chemical messengers that allow certain nerves in the brain to work. Venlafaxine AN SR modified release capsules increase the level of these two messengers. Experts think this is how it helps to restore your feeling of wellness.
Venlafaxine AN SR is not addictive.
Your doctor may have prescribed Venlafaxine AN SR modified release capsules for another purpose. Ask your doctor if you have any questions about why Venlafaxine AN SR modified release capsules has been prescribed for you.
Before you take Venlafaxine AN SR
When you must not take Venlafaxine AN SR
Do not take Venlafaxine AN SR if you are taking other medications for depression known as monoamine oxidase inhibitors, even if you have stopped taking them now, but have taken them within the last 14 days.
Do not take Venlafaxine AN SR if you are allergic to it or to any of the ingredients listed at the end of this leaflet.
Symptoms of an allergic reaction include:
- Rash, itching or hives on the skin
- Swelling of the face, lips, tongue or other parts of the body
- Shortness of breath, wheezing or troubled breathing.
Do not give Venlafaxine AN SR to children or adolescents under 18 years of age.
The safety and effectiveness of Venlafaxine AN SR in this age group have not been established.
Do not use Venlafaxine AN SR after the expiry date (EXP) printed on the pack.
If you take this medicine after the expiry date has passed, it may not work as well as it should.
Do not use Venlafaxine AN SR if the packaging is torn or shows signs of tampering.
Before you start to take Venlafaxine AN SR
Tell your doctor or pharmacist if you have allergies to the active ingredient or any of the other ingredients listed at the end of this leaflet.
Tell your doctor or pharmacist if you are pregnant or intend to become pregnant.
Venlafaxine AN SR is not recommended for use during pregnancy. Your doctor will discuss the risks and benefits of using Venlafaxine AN SR if you are pregnant. One of these risks is that newborn babies whose mothers have been taking Venlafaxine AN SR may have several problems including breathing difficulties, seizures and lack of oxygen in their blood.
Tell your doctor or pharmacist if you are breast-feeding or planning to breast-feed.
Venlafaxine AN SR passes into breast milk and there is a possibility that the breast-fed baby may be affected. For this reason, the use of Venlafaxine AN SR is not recommended in breast-feeding women.
Tell your doctor if you have, or have had, any medical conditions, especially the following:
- A history of fits (seizures or convulsions)
- A personal history or family history of bipolar disorder
- A history of aggression
- A history of restlessness or difficulty sitting still
- Blood pressure problems
- Glaucoma (increased pressure in the eye)
- A tendency to bleed more than normal or you are taking medicines to prevent blood clots
- Raised cholesterol levels or you are taking medicines to lower cholesterol
- Problems with your kidneys or liver
- Problems with your heart, especially conditions causing irregular heartbeats.
Your doctor may wish to do some heart tests such as an electrocardiogram (ECG) or blood tests during treatment with Venlafaxine AN SR.
- Any other medical conditions.
Tell your doctor if you plan to have surgery.
If you have not told your doctor about any of the above, tell them before you take Venlafaxine AN SR.
Taking other medicines
Tell your doctor or pharmacist if you take any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop, such as St Johns Wort or tryptophan supplements.
Do not start to take any other medicine while you are taking Venlafaxine AN SR, unless it is prescribed or approved by your doctor.
Some medicines may interfere with Venlafaxine AN SR or Venlafaxine AN SR may interfere with these medicines. These include:
- Medications for depression known as monoamine oxidase inhibitors (such as moclobemide, linezolid, phenelzine and tranylcypromine), even if you have stopped taking them now, but have taken them within the last 14 days. Your doctor or pharmacist can tell you what to do if you are taking any of these medicines.
- Any other medications for depression, anxiety, obsessive-compulsive disorder or premenstrual dysphoric disorder, including St John's Wort
- Medicines for treating mental disorders such as haloperidol, risperidone, lithium or clozapine.
- Tramadol, fentanyl, tapentadol, pethidine and methadone used to treat strong pain
- Cimetidine for reflux and stomach ulcers
- Triptans used to treat migraine
- Amiodarone or quinidine used to treat irregular heart beats
Your doctor may wish to do some heart tests such as an electrocardiogram (ECG) or blood tests if you are using either of these medicines whilst taking Venlafaxine AN SR.
- Metoprolol for high blood pressure or angina
- Medicines used to prevent blood clotting such as anti-coagulants and platelet inhibitors
- Indinavir for viral infections
- Antibiotics such as erythromycin and linezolid for bacterial infections
- Ketoconazole or fluconazole for fungal infections
You may need to use different amounts of your medicine, or you may need to take different medicines. Your doctor will advise you.
Your doctor or pharmacist has more information on medicines to be careful with or to avoid while taking Venlafaxine AN SR.
How to take Venlafaxine AN SR
Follow all directions given to you by your doctor or pharmacist carefully.
They may differ from the information contained in this leaflet.
If you do not understand the instructions on the box, ask your doctor or pharmacist for help.
How much to take
Your doctor will tell you how many capsules you need to take each day. This may depend on your age, your condition and whether or not you are taking any other medicines.
Depression and Anxiety
The usual starting dose is 75mg taken once daily. After 2 weeks, your doctor may increase the dose to 150 mg a day.
The usual starting dose is 37.5 mg taken once daily for the first 4 to 7 days, then increased to 75 mg taken once daily.
Do not change your dose unless your doctor tells you to.
If you have kidney or liver problems, you may need a lower dose of Venlafaxine AN SR.
If you have heart problems and your doctor wishes to increase your dose of Venlafaxine AN SR, your doctor may first do some blood tests or heart tests such as an electrocardiogram (ECG).
How to take it
Swallow the capsules whole with a glass of water or other non-alcoholic liquid.
Do not divide, crush, chew or dissolve the capsules in water.
Do not be concerned if you see small white granules or balls in your stools after taking Venlafaxine AN SR.
Inside Venlafaxine AN SR capsules are spheroids or small white balls that contain the venlafaxine active ingredient. These spheroids are released from the capsule into your gastrointestinal tract. As the spheroids travel the length of your gastrointestinal tract, venlafaxine is slowly released. The spheroid 'shell' remains undissolved and is eliminated in your stools. Therefore, even though, you may see spheroids in your stools, your dose of venlafaxine has been absorbed.
When to take it
Venlafaxine AN SR should be taken once daily with food, at approximately the same time each day.
This could be either in the morning or in the evening.
Taking it at the same time each day will have the best effect. It will also help you remember when to take it.
Avoid drinking alcohol while you are using Venlafaxine AN SR.
How long to take Venlafaxine AN SR
Continue taking your medicine for as long as your doctor tells you.
Although you may begin to feel better after two weeks, it may take several weeks before you feel much better. It is important to give Venlafaxine AN SR time to work.
This medicine helps to control your condition, but does not cure it. It is important to keep taking your medicine even if you feel well.
If you forget to take Venlafaxine AN SR
If it is less than 12 hours until your next dose, skip the dose you missed and then take your next dose when you are meant to. Otherwise, take it as soon as you remember, and then go back to taking as you would normally.
Do not take a double dose to make up for the dose you missed. Contact your doctor if you have missed more than two doses in a row.
Always finish the modified release capsules you are taking in the current pack before you start a new pack.
If you have trouble remembering when to take your medicine, ask your pharmacist for some hints.
If you take too much (overdose)
Immediately telephone your doctor or Poisons Information Centre for advice (tel: 13 11 26), or go to Accident and Emergency at your nearest hospital if you think you or anyone else may have taken too much Venlafaxine AN SR.
Do this even if there are no signs of discomfort or poisoning.
You may need urgent medical attention.
If you take too many Venlafaxine AN SR modified release capsules you may:
- Feel sleepy
- Have an increased heart rate or changes in heart rhythm
- Have a seizure (fits)
- Have breathing difficulties
- Become unconscious
- Have dilated pupils.
Keep the telephone number for these places handy whilst taking any medications.
While you are taking Venlafaxine AN SR
Things you must do
Visit your doctor regularly for a check up so that your progress can be checked.
Your doctor may do some tests (such as an electrocardiogram (ECG) or blood tests) from time to time to make sure the medicine is working and to prevent unwanted side effects.
Always discuss any questions you have about Venlafaxine AN SR modified release capsules with your doctor.
If you are going to have surgery, tell your doctor that you are taking this medicine.
Some agents used to assist your doctor during surgery may interact with Venlafaxine AN SR leading to unwanted side effects.
If you are about to have any urine tests, tell your doctor that you are taking this medicine.
It may interfere with the results of some tests.
Take Venlafaxine AN SR modified release capsules as your doctor has prescribed.
Keep enough Venlafaxine AN SR modified release capsules to last weekends and holidays.
This medicine helps to control your condition, but does not cure it. It is important to keep taking your medicine even if you feel well.
Tell any other doctors, dentists, and pharmacists who treat you that you are taking this medicine.
Watch carefully for signs that your depression or anxiety is getting worse, especially in the first few weeks of treatment or if your dose has changed.
Sometimes people with depression can experience a worsening of their depressive symptoms. This can happen even when taking an antidepressant.
Information from clinical trials has suggested that children, adolescents, and young adults (18-24 years), particularly those with depression, may be at increased risk of suicidal behaviour (including suicide attempts) if treated with venlafaxine, especially during initial treatment.
Tell your doctor immediately if you experience any of the following symptoms, especially if they are severe, you have not had these symptoms before or they happen very suddenly.
- Anxiety or agitation
- Panic attacks
- Difficulty sleeping
- Hostility or impulsiveness
- Overactivity or uninhibited behaviour
- Other unusual changes in behaviour
- Thoughts of suicide.
Tell your doctor immediately if you have any thoughts about suicide or doing harm to yourself.
Warning signs of suicide
If you or someone you know is showing the following warning signs, either contact your doctor or a mental health advisor right away or go to the nearest hospital for treatment.
All thoughts or talk about suicide or violence are serious.
- Thoughts or talk about death or suicide
- Thoughts or talk about self-harm or doing harm to others
- Any recent attempts of self-harm
- An increase in aggressive behaviour, irritability or agitation.
Things to be careful of
Be careful driving or operating dangerous machinery until you know how it affects you.
Venlafaxine AN SR modified release capsules may make you feel drowsy.
If you are feeling drowsy or are uncoordinated, be careful that you do not fall over.
Venlafaxine AN SR, like other medicines in this class, may increase your risk of bone fracture.
Things you must not do
Do not suddenly stop taking Venlafaxine AN SR modified release capsules or lower the dose if you have been taking it for some time.
Check with your doctor for the best way to slowly reduce the amount of Venlafaxine AN SR you are taking before stopping completely.
Side effects from stopping treatment with Venlafaxine AN SR may include:
- Nausea and vomiting
- Confusion and agitation
- Loss of appetite
- Impaired coordination and balance
- Tingling or numbness of the hands and feet.
Slowly reducing the amount of Venlafaxine AN SR being taken reduces the possibility of these effects occurring.
Some of these symptoms may impair driving, or the operation of dangerous machinery. These activities should be avoided if you experience these symptoms.
Do not give this medicine to anyone else even if they have the same condition as you.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Venlafaxine AN SR.
All medicines can have side effects. Sometimes they are serious; often they are not. You may need medical attention if you get some of the side effects.
It can be difficult to tell whether side effects are the result of taking this medicine, effects of your condition, or side effects of other medicines you may be taking. For this reason it is important to tell your doctor of any change in your condition.
Do not be alarmed by the list of side effects.
You may not experience any of them.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor if...
Tell your doctor if you notice any of the following and they worry you:
- Stomach, bowel or urinary tract problems such as:
- Nausea or vomiting
- Loss of appetite
- Difficulty passing urine, passing urine more frequently, or urinary incontinence.
- Changes in your behaviour such as:
- Difficulty sleeping or abnormal dreams
- Sexual function problems such as delayed ejaculation, problems with erection, decreased sex drive or difficulties achieving orgasm.
- Teeth grinding
- Impaired coordination and balance
Difficulty thinking or working because of:
- Feeling sedated or drowsy
- Fainting or dizziness after standing up
- Restlessness or difficulty sitting still
- Rapid heart beat
- Heavy or irregular menstrual periods.
- Hot flushes
- Hair loss
- Weight loss
- Weight gain
- Flow of milk in women who are not breastfeeding
- Blurred vision
- Ringing in the ears
- Altered taste
- Dry mouth
Tell your doctor as soon as possible if...
Tell your doctor as soon as possible if you notice any of the following:
- Muscle tremors, spasms, twitching, jerky movements or sustained muscle contractions
- Abnormal facial movements such as tongue thrusting, repetitive chewing, jaw swinging, or grimacing
- A feeling of apathy or not caring about things
- Unusually overactive
- Changes in muscle tone, muscle weakness or fatigue
- Numbness or pins and needles.
- Problems with breathing, shortness of breath
- Bleeding or bruising more easily than normal
- Sensitivity to sunlight.
Go to hospital if...
Tell your doctor immediately, or go to Accident and Emergency at your nearest hospital if you notice any of the following:
- Fits or seizures, which may be accompanied by a sudden fever
- Signs of allergy such as rash or hives, swelling of the face, lips or tongue, wheezing or difficulty breathing or swallowing
- Symptoms of sudden fever with sweating, rapid heart beat and muscle stiffness, which may lead to loss of consciousness
- Palpitations, shortness of breath, intense chest pain, or irregular heartbeats
- Dark, red or cola coloured urine, muscle weakness and tenderness, stiffness or aching
- Stomach pain, yellowing of the skin, nausea, fever, clammy skin and sweating
- Yellowing of the skin or eyeballs, fever, fatigue, loss of appetite, dark coloured urine or light coloured bowel movements
- A severe skin reaction with painful red areas and large blisters, accompanied by fever and chills, aching muscles and generally feeling unwell
- Symptoms of a high fever, agitation, confusion, trembling and abrupt contractions of muscles
- Signs of an infection such as severe chills, fever, sore throat and mouth ulcers.
- Black sticky bowel motions or bloody diarrhoea.
These symptoms are usually rare but may be serious and need urgent medical attention.
Tell your doctor or pharmacist if you notice anything else that is making you feel unwell.
Other side effects not listed above may also occur in some people. Some of these side effects (for example, increase in blood pressure or blood cholesterol) can only be found when your doctor does tests from time to time to check your progress.
After using Venlafaxine AN SR
Keep your Venlafaxine AN SR modified release capsules in their blister pack until it is time to take them.
The modified release capsules may not last as well if you take them out of the blister pack.
Keep Venlafaxine AN SR modified release capsules in a cool dry place where the temperature stays below 25°C.
Do not store Venlafaxine AN SR modified release capsules or any other medicine in the bathroom or near a sink. Do not leave Venlafaxine AN SR modified release capsules in the car or on windowsills.
Heat and dampness can destroy some medicines.
Keep Venlafaxine AN SR modified release capsules and all medication where young children cannot reach it.
A locked cupboard, at least one-and-a-half metres above the ground, is a good place to store medicines.
Return any unused medicine to your pharmacist.
What Venlafaxine AN SR looks like
There are three strengths of Venlafaxine AN SR modified release capsules, containing 37.5 mg, 75 mg or 150 mg of venlafaxine in a modified release formulation, which allows for once-a-day dosing. The modified release capsules have the following appearance:
37.5 mg, grey cap/peach body with thick and thin radial circular bands on the cap and body in red ink.
75 mg, peach cap and body with thick and thin radial circular bands on the cap and body in red ink.
150 mg, dark orange cap and body with thick and thin radial circular bands on the cap and body in white ink.
Venlafaxine AN SR 37.5 mg, 75 mg and 150 mg are available in blister packs containing 28 modified release capsules.
Venlafaxine AN SR modified release capsules contain venlafaxine hydrochloride as the active ingredient.
Venlafaxine AN SR 37.5 mg, 75 mg and 150 mg modified release capsules contain the following inactive ingredients:
- Cellulose - microcrystalline
- Talc, purified
- Silica – colloidal anhydrous
- Magnesium stearate
- Ethyl cellulose
- Titanium dioxide.
In addition to these,
Venlafaxine AN SR 37.5 mg modified release capsules also contain black iron oxide E172, red iron oxide E172, yellow iron oxide E172 and SB-1033 red ink;
Venlafaxine AN SR 75 mg modified release capsules also contain black iron oxide E172, red iron oxide E172 and SB-1033 red ink;
Venlafaxine AN SR 150 mg modified release capsules also contain Brilliant Blue FCF E 133, Allura Red AC E 129, Sunset Yellow FCF E 110 and SB-0007P white ink.
Venlafaxine AN SR does not contain gluten, sucrose, tartrazine or any other azo dyes.
Alembic Pharmaceuticals Australia Pty Ltd
Level 2 108 Power Street,
Hawthorn, VIC, 3122
Date of Information:
Australian registration numbers:
VENLAFAXINE AN SR 37.5 mg: AUST R 160293
VENLAFAXINE AN SR 75 mg: AUST R 160294
VENLAFAXINE AN SR 150 mg: AUST R 160295