- Medical termination of pregnancy is an alternative to surgical termination
Mifepristone followed by misoprostol is a safe and effective method for medical termination of pregnancy of up to 49 days' gestation.
- Mifepristone followed by misoprostol has efficacy and safety similar to those of surgical termination of pregnancy
It may cause more bleeding and painful cramps.
- Serious adverse events, such as infection, occur rarely
The woman must have access to 24-hour emergency care if required.
- Ectopic pregnancy must be excluded and gestational age confirmed, preferably by ultrasound, before prescribing
Ensure any intrauterine device is removed before termination is started.
- Mifepristone followed by misoprostol can be prescribed only by a suitably trained medical practitioner
Training is provided in Australia by MS Health, a subsidiary of Marie Stopes International.
What is known about this drug
Medical termination of a pregnancy of up to 49 days' gestation using mifepristone (200 mg) followed by misoprostol (800 microgram) is a well-established regimen that is safe and effective.
What does NPS MedicineWise say?
Medical termination of a pregnancy using the combination of mifepristone followed by misoprostol is safe and effective. The alternatives of medical or surgical termination of pregnancy should be offered to a woman if both are available and suitable for her.
For the termination of an intrauterine pregnancy of up to 49 days' gestation.
Who can prescribe and dispense it?
Some medical practitioners do not require training but must request certification from MS Health. These include Fellows ofRANZCOG, TGA Authorised Prescribers, and holders of an Advanced Diploma DRANZCOG from RANZCOG.2
Pharmacists are also required to request certification (as dispensers) from MS Health to purchase mifepristone and misoprostol. Pharmacists are required to confirm that medical practitioners are registered and certified with MS Health prior to dispensing. This can be done via the secure healthcare professional website (www.ms2step.com.au).
What is it?
Mifepristone (also known as RU-486) is a synthetic steroid and progesterone antagonist that competes with progesterone and blocks progesterone receptors.3
In pregnant women mifepristone's action on the uterus can induce abortion. It causes dilatation of the cervix and increases the sensitivity of the myometrium to the action of prostaglandins.
Misoprostol is a synthetic analogue of prostaglandin E1 that induces contractions of the smooth muscle fibres in the myometrium and relaxation of the uterine cervix.4
Mifepristone is followed 36–48 hours later with misoprostol to terminate a developing intrauterine pregnancy.5
Who is it for?
The combination of mifepristone followed by misoprostol is indicated for medical termination of a developing intrauterine pregnancy within 49 days of the start of a woman's last menstrual period.3,4
It is an alternative to surgical termination of early pregnancy that can be offered to women when it is suitable for them, for example, for women with no contraindications to mifepristone or misoprostol (see Safety issues).3,4
Candidates for medical termination of pregnancy must be able to adhere to the treatment regimen (including follow-up visits) and have access to a telephone and transportation to a medical facility in case of emergency.
Where does it fit?
Medical abortion became an alternative method of first-trimester pregnancy termination in the 1980s with the availability of prostaglandins and anti-progesterones.6
The efficacy and safety of mifepristone followed by misoprostol for medical termination of pregnancy is well established. This combination of medicines has been in use for up to 20 years in many countries, including France, China, the UK and US.7,8
Mifepristone has been available in Australia since 2006 through the TGA Authorised Prescriber Scheme and was included on the Australian Register of Therapeutic Goods (ARTG) in 2012.1
Misoprostol was registered in Australia in 2012 for use orally or buccallya in combination with mifepristone for termination of pregnancy of up to 49 days' gestation.4
* Buccal administration of misoprostol involves the tablet being kept between the cheek and the gum for 30 minutes before any fragments are swallowed with water.4
Proven efficacy for termination of pregnancy of up to 49 days' gestation
The efficacy and safety of mifepristone followed by misoprostol for termination of early pregnancy was established in four pivotal trials conducted in France, the UK and US. The overall rate of success was high, with complete termination of pregnancy achieved in 92–97% of women who were pregnant for up to 49 days.9–12
Subsequent clinical trials have demonstrated consistent efficacy of at least 93% with mifepristone (200 mg) followed by misoprostol (800 micrograms) 24–48 hours later.3,4,13
Not approved in Australia for termination of pregnancy after 49 days
In Australia medical termination of pregnancy using mifepristone followed by misoprostol is not approved by the TGA for use after 49 days of gestation. However, this combination of drugs is widely accepted and safely used overseas up to 63 days' gestation.14
Termination of pregnancy after 49 days' gestation using mifepristone followed by oral misoprostol has lower efficacy rates than termination up to 49 days — often less than 90%. A decline in efficacy was not observed using buccal misoprostol up to 63 days.3,4,13
Medical termination of pregnancy after 49 days' gestation is associated with slightly more adverse events, including bleeding, pain and a higher rate of complications.15
An alternative to surgical termination of pregnancy
Women can choose their preferred option if both alternatives for termination of pregnancy are suitable and available. Having a choice of method for termination of pregnancy may improve a woman's psychological outcome.16
In a UK study the most frequent reason for choosing medical abortion was to avoid some aspects of the operative process, particularly the anaesthetic (61%), or because women viewed the process as simpler and more natural (32%). Women who chose surgical termination of pregnancy generally wanted to avoid the awareness and involvement in the process of termination (49%) and were concerned about the pain (16%) or emotional impact (14%) of medical termination.17
Legal and regulatory requirements for termination of pregnancy
Termination of pregnancy by any method needs to be conducted in accordance with the legal and regulatory requirements of the jurisdiction where it occurs. Relevant law varies between Australian States and Territories.
Refer to the Children by Choice Fact Sheet: Australian abortion law and practice18 for a summary of current Australian legislative provisions relevant to abortion.
Prevention of future unintended pregnancy is a priority
Medical practitioners have an important role in prevention of unintended or unwanted pregnancy, through taking up opportunities for individual counselling and population health promotion about relationships, safe sex and contraceptive use.19
How does it compare?
The most effective regimen for medical termination
The most widely researched drugs for medical termination of early pregnancy are:6
- mifepristone with prostaglandins (misoprostol or gemeprost)
- prostaglandins alone
- mifepristone alone
- methotrexate alone
- methotrexate with prostaglandins.
Evidence suggests that combined regimens such as mifepristone followed by misoprostol are more effective than single agents.6 A combined regimen of mifepristone followed by misoprostol is faster and more effective than a combination of methotrexate followed by misoprostol.20
Different prostaglandins can be used with mifepristone for medical abortion, such as gemeprost, but misoprostol is superior because it is more cost effective, does not require refrigeration and offers different routes of administration.6
Buccal administration of misoprostol is absorbed more slowly than oral administration, but appears to induce higher overall uterine activity. Efficacy rates for mifepristone followed by misoprostol administered either orally or buccally are comparable for women at 43–49 days (94.7% vs 96.4%, respectively).4
Similar efficacy to that of surgical termination
Different surgical methods for termination of early pregnancy are available, with various levels of efficacy:
- dilatation and curettage
- power-operated vacuum aspiration
- manual vacuum aspiration or hysterotomy (not commonly used).21
A Cochrane review found insufficient data to make recommendations about which surgical methods are favoured for early termination of pregnancy.21
In general, medical termination of early pregnancy is considered to have similar efficacy to that of surgical termination.22,23 For example, vacuum aspiration, which is a common method for surgical terminations of early pregnancy, has similar efficacy to medical termination of pregnancy using mifepristone followed by misoprostol.22
However, surgical termination of early pregnancy appears to have higher rates of complete abortion, with less than 2–4% failure rate.23–27
Patient experience after termination of pregnancy
Satisfaction with both medical and surgical methods for termination of early pregnancy is high.27–29 The health outcomes appear to be similar with both methods, but many women have a strong preference for one approach.27,29,30
Recovery after medical and surgical termination of early pregnancy is estimated to be the same. For example, even though women who underwent vacuum aspiration required more time off work than those who underwent medical abortion (2.4 vs 1.3 days), the time taken for return to normal daily activities was similar for both groups.22
Choice of the method for termination
Medical termination of early pregnancy is an alternative to surgical termination and ideally both methods should be offered to ensure the woman understands that she has a choice.
For a woman the choice between surgical and medical abortion involves balancing the benefits and risks of both methods (Table 1). The risk of surgery and anaesthesia is balanced against the risk of a medical method with a slightly lower efficacy, involving more pain and bleeding.
Some women may feel more in control using a medical method, but this method may be perceived a more unpleasant option by others.
Table 1 Advantages and disadvantages of medical and surgical abortion
Expected consequences of medical abortion using mifepristone followed by misoprostol are heavy uterine bleeding and painful uterine contractions or cramps.7 Cramps are similar to those experienced during a menstrual cycle or labour. For most women the pain is adequately managed with OTC analgesics.19
Many of the side effects experienced during medical abortion are associated with misoprostol use. Common transient side effects from these drugs include:3,4,19
- nausea: experienced by about 40–70% women
- vomiting: experienced by about 10–45% women
- diarrhoea: experienced by about 10–30% women
- headache, fever, chills and fatigue.
Most women find the side effects acceptable. The rate of any serious adverse event or complication after medical termination of early pregnancy is low.8
Persistent bleeding for longer than 16 days occurs rarely
Bleeding associated with medical termination of pregnancy usually occurs within 4–6 hours of misoprostol administration in > 95% of women.3,4 Some vaginal bleeding may continue for an average of 10–16 days after mifepristone administration.3,4
Advise women experiencing heavy bleeding for > 2 days after misoprostol administration to seek medical advice. In 0.1–0.2% of women terminating pregnancy up to 49 days' gestation, the bleeding is heavy enough to cause anaemia and may require a blood transfusion.3,4
If persistent bleeding (even if light) is reported at the follow-up visit at 14–21 days, arrange a further appointment within a few days to assess cause. Persistent bleeding can be a consequence of incomplete abortion or an unnoticed extrauterine pregnancy and may require surgical intervention.3,4
As with other types of abortion, cases of serious bacterial infection, including very rare cases of fatal septic shock, have been reported after use of mifepristone followed by misoprostol.3,4
Fever, severe abdominal pain, nausea, vomiting or pelvic tenderness in the days after a medical abortion may indicate presence of an infection.3
There is currently insufficient evidence to recommend the use of prophylactic antibiotics for women having a medical abortion.32
Failures requiring surgical intervention
The overall failure rate of mifepristone followed by misoprostol is about 2–7%. Failure can be caused by incomplete abortion (about 2–4% of failures) or ongoing pregnancy (about 1% of failures).13
Surgical intervention is undertaken in ≤ 5% of women undergoing medical abortion for continuing viable pregnancy or, more commonly, incomplete abortion.19
The frequency of surgical evacuation of the uterus is reported to decrease with increasing experience of the clinical team with the medical method.33,34
Follow-up is essential due to risk of failure
Follow-up is essential 14–21 days after mifepristone administration to verify that expulsion has completed, vaginal bleeding has stopped and to exclude complications such as infection.3
If medical termination fails and ongoing pregnancy is confirmed with an ultrasound, offer termination of pregnancy by a surgical method.3
There is unknown risk to the foetus after exposure to mifepristone, but use of misoprostol is associated with birth defects.3
Long-term risks associated with termination of pregnancy
There does not appear to be an association between termination of pregnancy and risk of miscarriage, preterm birth or placenta praevia in subsequent pregnancies.19
Evidence does not support an association between termination of pregnancy and infertility, ectopic pregnancy or breast cancer.19
It appears that after one medical versus one surgical termination of pregnancy, obstetric risks for delivery in subsequent pregnancies are similar.35
Similar safety profile compared with that for surgical termination
Women who choose medical termination using mifepristone followed by misoprostol over surgical termination are more likely to experience adverse events such as bleeding, abdominal pain, nausea and vomiting.23,24,27,36
There is a low and comparable incidence of serious complication rates with surgical and medical methods for termination of pregnancy.8,37,38 A Cochrane systematic review reported no significant difference in the rate of complications between surgical and medical methods of abortion in the first trimester, although there were few sufficiently powered randomised studies to identify different rates for rare events.38
A large registry-based cohort study of more than 42,000 women in Finland compared complication rates after medical and surgical termination of early pregnancy and reported that both methods were safe.37
The incidence of haemorrhage or incomplete abortion was higher in women undergoing medical termination, while complications requiring surgical treatment were more common after surgical termination of pregnancy. The rates of infection and serious morbidity did not differ between the groups.37
Contraindications to mifepristone and misoprostol
Contraindications to mifepristone and misoprostol medical abortion include:
- chronic adrenal failure
- severe disease requiring steroid administration
- hypocoagulation diseases
- anticoagulant therapy
- allergy to mifepristone, misoprostol or other prostaglandin.3,4
This regimen is not recommended in women with anaemia, renal failure, hepatic impairment, malnutrition or cardiovascular disease.3,4
Before prescribing mifepristone and misoprostol ensure ectopic pregnancy is excluded, gestational age is confirmed as no more than 49 days and any intrauterine device is removed before treatment.3,4
For information about reporting adverse reactions to the TGA, or to report suspected adverse reactions online, see the TGA website or use the 'Blue Card' distributed three times a year with Australian Prescriber.
Reason for PBS listing
The PBAC recommended listing of mifepristone followed by misoprostol for medical termination of an intrauterine pregnancy of up to 49 days' gestation on the basis of similar effectiveness and cost compared with surgical termination of pregnancy.39
Before mifepristone administration
Discuss pain relief using paracetamol or OTC analgesics. Evidence supports the pre-emptive use of ibuprofen for pain relief.40
In all instances, the use of mifepristone requires prior rhesus determination.3
A single mifepristone tablet (200 mg) should be swallowed with water. Evidence suggests that 200 mg of mifepristone is as effective as higher doses (600 mg).41 In about 3% of pregnancies the products of conception will be expelled before misoprostol is administered.3
Misoprostol administration (36–48 hours after mifepristone)
Misoprostol should be taken 36–48 hours after mifepristone administration. Acceptable regimens for oral or buccal administration of misoprostol tablets (200 microgram tablet) are:
- 800 micrograms (four tablets) in a single dose
- 400 micrograms (two tablets) to be repeated after 2 hours.4
Advise the woman to stay at home and rest for 4–6 hours after taking misoprostol tablets or until the expulsion process is complete. Some women choose to be in the clinic for this part of the treatment. It is highly desirable that a support person is present who knows how to access emergency care if it is required.
Additional misoprostol dose (1–7 days after initial misoprostol)
If abortion has not occurred after the initial dose of misoprostol, an additional dose of misoprostol (up to 800 micrograms) can be prescribed from 1 to 7 days later.4
Follow-up examination is essential (14–21 days after mifepristone)
Advise the woman to return to the clinic 14–21 days after mifepristone administration to ensure termination of pregnancy is complete.3,4
Information for patients
If a woman chooses to terminate pregnancy using mifepristone followed by misoprostol, provide specific and clear instructions for this method.
Provide a written list of the symptoms women may experience during medical termination of pregnancy and those that require urgent medical consultation.
Advise a woman undergoing medical termination of pregnancy as follows.
- It is highly desirable to have a support person present who will stay with you until the abortion process is complete.
- Take mifepristone and oral misoprostol tablets with water 2 hours before or 2 hours after a meal.
- If using buccal administration of misoprostol, keep the tablet between the cheek and the gum for 30 minutes before swallowing any remaining fragments with water.
- After taking misoprostol tablets, stay at home and rest for 4–6 hours or until the expulsion process is complete.
- Vaginal bleeding will usually occur and the products of conception may be expelled within a few hours of taking misoprostol or during the next few days.
- Bleeding may last up to 10–16 days but should not be heavy for > 2 days.
- Ensure access to emergency care and a 24-hour phone service.
- Follow-up is essential within 14–21 days after taking mifepristone to confirm that the pregnancy is terminated.
- If ongoing pregnancy is confirmed, surgical termination of pregnancy is required due to risks of teratogenic effects from one or both drugs.
- Consider contraceptive options and, when appropriate, start contraception after the abortion process.
An NPS Medicine Update article on mifepristone followed by misoprostol for termination of pregnancy is available for consumers. Medicine Update helps consumers to ask the right questions about new medicines and helps them compare the potential benefits and harms of a new medicine with those of other medicines.
- Therapeutic Goods Administration. Registration of mifepristone linepharma (RU 486) and GyMiso (misoprostol). 2012. http://www.tga.gov.au/newsroom/btn-tga-statement-mifepristone-gymiso-120830.htm (accessed 26 April 2013).
- The Royal Australian and New Zealand College of Obstetricians and Gynaecologists. The use of mifepristone for medical termination of pregnancy. RANZCOG, 2012. http://www.ranzcog.edu.au/component/docman/doc_details/929-c-gyn-21-the-use-of-mifepristone-for-medical-termination-of-pregnancy.html?Itemid=580 (accessed 1 May 2013).
- MStopes Health. Mifepristone Linepharma product information. https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2012-PI-02513-1 (accessed 25 July 2013).
- MS Stopes Health. GyMiso product information. 18 September 2012. https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2012-PI-02514-1 (accessed 25 July 2013).
- Australian Prescriber. New Drugs: Mifepristone. 2013. http://www.australianprescriber.com/magazine/36/1/32/5/new-drugs-1015/mifepristone (accessed 8 May 2013).
- Kulier R, Kapp N, Gulmezoglu AM, et al. Medical methods for first trimester abortion. Cochrane Database Syst Rev 2011:CD002855. [PubMed]
- Sitruk-Ware R. Mifepristone and misoprostol sequential regimen side effects, complications and safety. Contraception 2006;74:48\u201355. [PubMed]
- Mulligan E, Messenger H. Mifepristone in South Australia \u2013 the first 1343 tablets. Aust Fam Physician 2011;40:342-5; quiz 51\u20132. [PubMed]
- Aubeny E, Peyron R, Turpin CL, et al. Termination of early pregnancy (up to 63 days of amenorrhea) with mifepristone and increasing doses of misoprostol. Int J Fertil Menopausal Stud 1995;40[Suppl.2]:85\u201391. [PubMed]
- Peyron R, Aubeny E, Targosz V, et al. Early termination of pregnancy with mifepristone (RU 486) and the orally active prostaglandin misoprostol. N Engl J Med 1993;328:1509\u201313. [PubMed]
- Spitz IM, Bardin CW, Benton L, et al. Early pregnancy termination with mifepristone and misoprostol in the United States. N Engl J Med 1998;338:1241\u20137. [PubMed]
- Urquhart DR, Templeton AA, Shinewi F, et al. The efficacy and tolerance of mifepristone and prostaglandin in termination of pregnancy of less than 63 days gestation; UK multicentre study \u2013 final results. Contraception 1997;55:1\u20135. http://www.sciencedirect.com/science/article/pii/S0010782496002521
- Kahn JG, Becker BJ, MacIsaa L, et al. The efficacy of medical abortion: a meta-analysis. Contraception 2000;61:29\u201340. [PubMed]
- Royal College of Obstetricians and Gynaecologists. The care of women requesting induced abortion. 2004. http://www.rcog.org.uk/files/rcog-corp/Abortion guideline_web_1.pdf (accessed 6 May 2013).
- de Costa CM, Carrette M. Early medical abortion \u2013 available and safe. Med J Aust 2012;197:257\u20138. [PubMed]
- Crandell L. Psychological outcomes of medical versus surgical elective first trimester abortion. Nurs Womens Health 2012;16:296\u2013307. [PubMed]
- Slade P, Heke S, Fletcher J, et al. A comparison of medical and surgical termination of pregnancy: choice, emotional impact and satisfaction with care. Br J Obstet Gynaecol 1998;105:1288\u201395. [PubMed]
- Children by Choice Association Inc. Fact sheet: Australian abortion law and practice. http://www.childrenbychoice.org.au/info-a-resources/facts-and-figures/australian-abortion-law-and-practice (accessed 8 May 2013).
- The Royal Australian and New Zealand College of Obstetricians and Gynaecologists. Termination of pregnancy: a resource for health professionals. 2005. http://www.ranzcog.edu.au/publication/womens-health-publications/termination-of-pregnancy-booklet.html (accessed 1 May 2013).
- Dahiya K, Madan S, Hooda R, et al. Evaluation of the efficacy of mifepristone/misoprostol and methotrexate/misoprostol for medical abortion. Indian J Med Sci 2005;59:301\u20136. [PubMed]
- Kulier R, Fekih A, Hofmeyr GJ, et al. Surgical methods for first trimester termination of pregnancy. Cochrane Database Syst Rev 2001:CD002900. [PubMed]
- Henshaw RC, Naji SA, Russell IT, et al. A comparison of medical abortion (using mifepristone and gemeprost) with surgical vacuum aspiration: efficacy and early medical sequelae. Hum Reprod 1994;9:2167\u201372. [PubMed]
- Winikoff B, Sivin I, Coyaji KJ, et al. Safety, efficacy, and acceptability of medical abortion in China, Cuba, and India: a comparative trial of mifepristone-misoprostol versus surgical abortion. Am J Obstet Gynecol 1997;176:431\u20137. [PubMed]
- Creinin MD. Randomized comparison of efficacy, acceptability and cost of medical versus surgical abortion. Contraception 2000;62:117\u201324. [PubMed]
- Paul ME, Mitchell CM, Rogers AJ, et al. Early surgical abortion: efficacy and safety. Am J Obstet Gynecol 2002;187:407\u201311. [PubMed]
- Rorbye C, Norgaard M, Nilas L. Medical versus surgical abortion efficacy, complications and leave of absence compared in a partly randomized study. Contraception 2004;70:393\u20139. [PubMed]
- Cabezas E. Medical versus surgical abortion. Int J Gynaecol Obstet 1998;63[Suppl.1]:S141\u20136. [PubMed]
- Rorbye C, Norgaard M, Nilas L. Medical versus surgical abortion: comparing satisfaction and potential confounders in a partly randomized study. Hum Reprod 2005;20:834\u20138. [PubMed]
- Mamers PM, Lavelle AL, Evans AJ, et al. Women's satisfaction with medical abortion with RU486. Med J Aust 1997;167:316\u20137. [PubMed]
- Therapeutic Goods Administration. Registration of medicines for the medical termination of early pregnancy. 2012. http://www.tga.gov.au/hp/information-medicines-mifepristone-gymiso.htm (accessed 1 May 2013).
- International Planned Parenthood Federation. First trimester abortion guidelines and protocols 2008. http://ippf.org/resource/First-Trimester-Abortion-Guidelines-and-Protocols (accessed 1 May 2013).
- U.S. Food and Drug Administration. Postmarket Drug Safety Information for Patient and Providers: Mifeprex (mifepristone) information. 2011 http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm111323.htm (accessed 22 May 2013).
- Bygdeman M, Danielsson KG. Options for early therapeutic abortion: a comparative review. Drugs 2002;62:2459\u201370. [PubMed]
- Baird DT. Medical abortion in the first trimester. Best Pract Res Clin Obstet Gynaecol 2002;16:221\u201336. [PubMed]
- Mannisto J, Mentula M, Bloigu A, et al. Medical versus surgical termination of pregnancy in primigravid women \u2013 is the next delivery differently at risk? A population-based register study. BJOG 2013;120:331\u20137. [PubMed]
- Elul B, Ellertson C, Winikoff B, et al. Side effects of mifepristone-misoprostol abortion versus surgical abortion. Data from a trial in China, Cuba, and India. Contraception 1999;59:107\u201314. [PubMed]
- Niinimaki M, Pouta A, Bloigu A, et al. Immediate complications after medical compared with surgical termination of pregnancy. Obstet Gynecol 2009;114:795\u2013804. [PubMed]
- Say L, Kulier R, Gulmezoglu M, et al. Medical versus surgical methods for first trimester termination of pregnancy. Cochrane Database Syst Rev 2002:CD003037. [PubMed]
- Pharmaceutical Benefits Scheme. March 2013 PBAC Outcomes \u2013 Positive Recommendations. 2013. http://www.pbs.gov.au/info/industry/listing/elements/pbac-meetings/pbac-outcomes/2013-03/positive-recommendations
- Avraham S, Gat I, Duvdevani NR, et al. Pre-emptive effect of ibuprofen versus placebo on pain relief and success rates of medical abortion: a double-blind, randomized, controlled study. Fertil Steril 2012;97:612\u20135. [PubMed]
- Comparison of two doses of mifepristone in combination with misoprostol for early medical abortion: a randomised trial. World Health Organization Task Force on Post-ovulatory Methods of Fertility Regulation. BJOG 2000;107:524\u201330. [PubMed]