Nitrofurantoin and fosfomycin for resistant urinary tract infections: old drugs for emerging problems
Uncomplicated urinary tract infection is one of the most common indications for antibiotic use in the community. However, the Gram-negative organisms that can cause the infection are becoming more resistant to antibiotics.
Many multidrug resistant organisms retain susceptibility to two old antibiotics, nitrofurantoin and fosfomycin. Advantages over newer drugs include their high urinary concentrations and minimal toxicity.
Bradley J Gardiner, Andrew J Stewardson, Iain J Abbott, Anton Y Peleg Aust Prescr 2019;42:14-9
This activity should take around 1 hour to complete. It can be included in a pharmacist’s CPD plan for either one Group 1 credit or, on successful completion of the assessment activity, two Group 2 credits. Pharmacists should self-record this activity.
Pharmacy Competency Standards
1.6 Contribute to continuous improvement in quality and safety.
3.3 Monitor and evaluate medication management.
3.5 Support Quality Use of Medicines
This activity has been designed to take around 1 hour to complete - this is based on reading the article from an issue of Australian Prescriber and completing a quiz. You will be provided with immediate feedback on your answers and a certificate of completion will be available for you to download for self-reporting purposes.
It can be included in a pharmacist’s CPD plan for either one Group 1 credit or, on successful completion of the assessment activity, two Group 2 credits. Pharmacists should self-record this activity.
Please note that the assessment may only be attempted twice.
- Identify adverse effects and drug interactions with nitrofurantoin and fosfomycin.
- Understand the basic pharmacokinetics of nitrofurantoin and fosfomycin.
- Know indications and contraindications of nitrofurantoin and fosfomycin.
- Describe dosing recommendations of nitrofurantoin and fosfomycin.