Journal reading

P-glycoprotein and its role in drug-drug interactions

Efflux transporters such as P-glycoprotein play an important role in drug transport in many organs. In the gut, P-glycoprotein pumps drugs back into the lumen, decreasing their absorption.

Andrew Finch and Peter Pillans, Aust Prescr 2014;37:137-9

  • Cost: free
P-glycoprotein and its role in drug-drug interactions

CPD Points

This activity should take approximately 1 hour to complete. It can be included in a pharmacist’s CPD Plan for either one Group 1 credit or, on successful completion of the assessment activity, two Group 2 credits. Pharmacists should self-record this activity for CPD purposes.

Pharmacy Competency Standards

  • 1.4 Manage quality and safety
  • 7.1 Contribute to therapeutic decision making
  • 7.3 Influence patterns of medicine use


This activity has been designed to take around 1 hour to complete - this is based on reading the article from an issue of Australian Prescriber and completing a quiz. You will be provided with immediate feedback on your answers and a certificate of completion will be available for you to download for self-reporting purposes.


Learning objectives

  1. Understand the role of P-glycoprotein in drug disposition
  2. Predict drug interactions involving P-glycoprotein