1. Why am I using Amvuttra?
Amvuttra contains the active ingredient vutrisiran.
Amvuttra is used to treat an illness which runs in families called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis).
- hATTR amyloidosis is caused by problems with a protein in the body called ‘transthyretin’ (TTR).
- This protein is made mostly in the liver and carries vitamin A and other substances around the body.
- In people with this illness, small fibres of TTR protein clump together to make deposits called ‘amyloid’.
- Amyloid can build up around or within the nerves, heart, and other places in the body, stopping them from working normally. This causes the symptoms of the illness.
Amvuttra works by lowering the amount of TTR protein made by the liver which means there is less TTR protein in the blood that can form amyloid. This can help to reduce the effects of this illness. Amvuttra is used in adults only.
Published by MIMS June 2025