1. Why am I using ANDEMBRY®?
ANDEMBRY® contains the active ingredient garadacimab.
ANDEMBRY® is a monoclonal antibody.
ANDEMBRY® is used in adults and children aged 12 years and older to prevent swelling attacks in patients with hereditary angioedema (HAE).
Hereditary angioedema is a rare genetic disease in which people do not produce enough (deficiency) working C1 esterase inhibitor (C1-INH) protein, leading to an overproduction of bradykinin. Bradykinin causes blood vessels to leak fluids into the surrounding tissue resulting in spontaneous and unpredictable swelling attacks as seen in HAE. These can typically occur in the hands, feet, face, abdomen, genitals, tongue and larynx (voice-box).
How does ANDEMBRY® work?
ANDEMBRY® prevents HAE attacks by inhibiting a protein known as factor XIIa (FXIIa) from starting the events that lead to bradykinin overproduction.
2. What should I know before I use ANDEMBRY®?
Warnings
Do not use ANDEMBRY® if:
- you are allergic to garadacimab, or any of the ingredients listed at the end of this leaflet.
Published by MIMS September 2025