Consumer medicine information

Codral Original Day & Night Tablets

Paracetamol; Pseudoephedrine hydrochloride; Triprolidine hydrochloride

BRAND INFORMATION

Brand name

Codral Original Day & Night

Active ingredient

Paracetamol; Pseudoephedrine hydrochloride; Triprolidine hydrochloride

Schedule

S3

 

Consumer medicine information (CMI) leaflet

Please read this leaflet carefully before you start using Codral Original Day & Night Tablets.

FULL CMI

CODRAL Original Day & Night

Active ingredient(s): Paracetamol and Pseudoephedrine hydrochloride and Triprolidine hydrochloride


Consumer Medicine Information (CMI)

This leaflet provides important information about using CODRAL Original Day & Night. You should also speak to your doctor or pharmacist if you would like further information or if you have any concerns or questions about using CODRAL Original Day & Night.

Where to find information in this leaflet:

1. Why am I using CODRAL Original Day & Night?
2. What should I know before I use CODRAL Original Day & Night?
3. What if I am taking other medicines?
4. How do I use CODRAL Original Day & Night?
5. What should I know while using CODRAL Original Day & Night?
6. Are there any side effects?
7. Product details

1. Why am I using CODRAL Original Day & Night?

CODRAL Original Day & Night contains the active ingredients Paracetamol and Pseudoephedrine hydrochloride and Triprolidine hydrochloride. Paracetamol is an analgesic. It works to stop the pain messages from getting through to the brain. It also acts in the brain to reduce fever. Pseudoephedrine hydrochloride belongs to a group of medicines called sympathomimetic decongestants. It works by reducing congestion in the upper respiratory tract, including the nose, nasal passages and sinuses, and making it easier to breathe. Triprolidine belongs to a group of medicines called 'antihistamines'. Antihistamines help reduce allergic symptoms by preventing the effects of a substance called histamine. Histamine is produced by the body in response to foreign substances that the body is allergic to.

CODRAL Original Day & Night is used for the temporary relief from the symptoms of cold and flu. 'Day' tablet relieves runny nose, blocked nose, headache, body aches and pains, and fever. 'Night' tablet relieves runny nose, blocked nose, headache, body aches and pains, fever and sneezing.

2. What should I know before I use CODRAL Original Day & Night?

Warnings

Do not use CODRAL Original Day & Night if:

  • you are allergic to Paracetamol, Pseudoephedrine hydrochloride, Triprolidine hydrochloride or other antihistamines, or any of the ingredients listed at the end of this leaflet.
    Always check the ingredients to make sure you can use this medicine.
  • you are younger than 12 years
  • have very high blood pressure
  • have severe coronary artery disease (heart disease caused by poor blood flow or narrowing of the blood vessels of the heart)
  • have taken other products containing paracetamol
  • have taken antihistamines
  • have taken monoamine oxidase inhibitors, medicines used to treat depression, in the last 14 days.

Check with your doctor or pharmacist if you:

  • have any other medical conditions
    - respiratory condition (such as emphysema, chronic bronchitis or acute or chronic bronchial asthma)
    - high blood pressure
    - overactive thyroid gland
    - diabetes
    - heart disease and poor blood flow in the blood vessels of the heart
    - glaucoma (high pressure in the eyes)
    - prostate problems
    - liver or kidney disease
    - alcohol dependence
    - epilepsy
  • take sedatives
  • take any medicines for any other condition

During treatment, you may be at risk of developing certain side effects. It is important you understand these risks and how to monitor for them. See additional information under Section 6. Are there any side effects?

Pregnancy and breastfeeding

Check with your doctor or pharmacist if you are pregnant or intend to become pregnant.

Talk to your doctor or pharmacist if you are breastfeeding or intend to breastfeed.

Small amounts of pseudoephedrine pass into the breast milk. Your pharmacist or doctor will discuss the potential benefits and risks of taking the medicine if you are breastfeeding.

3. What if I am taking other medicines?

Tell your doctor or pharmacist if you are taking any other medicines, including any medicines, vitamins or supplements that you buy without a prescription from your pharmacy, supermarket or health food shop.

Some medicines may interfere with CODRAL Original Day & Night and affect how it works.

These include

  • medicines used to treat depression especially monoamine oxidase inhibitors and tricyclic antidepressants
  • medicines used to treat heart conditions
  • medicines used to treat high blood pressure
  • medicines used to treat urinary tract infections and bladder problems
  • medicines used to treat behavioral disorders
  • phenylephrine, a medicine used to treat congestion
  • appetite suppressants
  • warfarin, a medicine used to prevent blood clots
  • metoclopramide, a medicine used to control nausea and vomiting
  • medicines used to treat epilepsy or fits
  • chloramphenicol, an antibiotic used to treat ear and eye infections
  • alcohol
  • medicines used to help you sleep or relax (sedatives and hypnotics)
  • opioid analgesics, medicines used to treat pain
  • flucloxacillin, an antibiotic used to treat skin infections.

You may need different amounts of your medicines, or you may need to take different medicines.

Check with your doctor or pharmacist if you are not sure about what medicines, vitamins or supplements you are taking and if these affect CODRAL Original Day & Night.

4. How do I use CODRAL Original Day & Night?

How much to take

  • The recommended dose of CODRAL Original Day & Night for adults and children over 12 years is
    Day time: 2 Day tablets in the morning and 2 tablets in the afternoon, as necessary
    Night time: 2 Night tablets at night time, as necessary
  • Follow the instructions provided with the medicine.
  • Do not exceed 4 day tablets and 2 night tablets in 24 hours.
  • Do not exceed the recommended dosage.

When to take CODRAL Original Day & Night

  • Day tablets should be taken in the morning and in the afternoon, as necessary.
  • Night capsules should be taken in the evening, as necessary.

How to take CODRAL Original Day & Night

  • Swallow the tablets whole.
  • Do not use for more than a few days at a time except on medical advice.
  • Follow all directions given to you by your pharmacist or doctor carefully. This may differ from the information contained in this leaflet.
  • If you forget to take it and it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise, you may take a dose as soon as you remember if you think you need it. Do not take a double dose to make up for the dose that you missed.
  • If you do not understand the instructions on the pack, ask your pharmacist or doctor for help.

If you use too much CODRAL Original Day & Night

If you think that you have used too much CODRAL Original Day & Night, you may need urgent medical attention.

You should immediately:

  • phone the Poisons Information Centre
    (by calling 13 11 26), or
  • contact your doctor, or
  • go to the Emergency Department at your nearest hospital.

You should do this even if there are no signs of discomfort or poisoning.

5. What should I know while using CODRAL Original Day & Night?

Things you should do

Stop use and talk to your doctor or pharmacist if your symptoms persist, worsen, or if new symptoms occur. Your doctor or pharmacist will assess your condition and decide if you should continue to take the medicine.

Remind any doctor, dentist or pharmacist you visit that you are using CODRAL Original Day & Night.

Things you should not do

  • Do not take CODRAL Original Day & Night to treat any other complaints unless your pharmacist or doctor tells you to.
  • Do not give your medicine to anyone else, even if they have the same condition as you.
  • Do not take more than the recommended dose unless your pharmacist or doctor tells you to.

Driving or using machines

Be careful before you drive or use any machines or tools until you know how CODRAL Original Day & Night affects you.

CODRAL Original Day & Night may cause dizziness in some people.

If this happens, do not drive or operate machinery.

Drinking alcohol

Tell your doctor or pharmacist if you drink alcohol.

Looking after your medicine

  • Keep your medicine in the original pack until it is time to take.
  • Keep your medicine in a cool dry place where the temperature stays below 25°C.

Follow the instructions in the carton on how to take care of your medicine properly.

Store it in a cool dry place away from moisture, heat or sunlight; for example, do not store it:

  • in the bathroom or near a sink, or
  • in the car or on window sills.

Keep it where young children cannot reach it.

Getting rid of any unwanted medicine

If you no longer need to use this medicine or it is out of date, take it to any pharmacy for safe disposal.

Do not use this medicine after the expiry date.

6. Are there any side effects?

All medicines can have side effects. If you do experience any side effects, most of them are minor and temporary. However, some side effects may need medical attention.

See the information below and, if you need to, ask your doctor or pharmacist if you have any further questions.

Less serious side effects

Less serious side effectsWhat to do
  • nausea or dyspepsia
  • stomach discomfort
  • diarrhoea
  • vomiting
  • constipation
  • drowsiness or sleepiness
  • dizziness
  • insomnia
  • difficulty sleeping
  • nervousness
  • excitability
  • feeling of extreme happiness
  • restlessness
  • fear or anxiety
  • twitching or jerking muscles
  • dry mouth, nose and throat
  • nose bleed
  • rapid or irregular heart beat
  • tremor
  • headache
  • hallucinations
  • rectal bleeding
  • small bumps on the skin with or without fever or reddening of the skin
Speak to your doctor or pharmacist if you have any of these less serious side effects and they worry you.

Serious side effects

Serious side effectsWhat to do
  • urine retention
  • pain when passing urine
  • seizures (fits)
  • shortness of breath
  • wheezing or difficulty breathing
  • swelling of the face, lips, tongue, or other parts of the body
  • rash, itching or hives on the skin
Call your doctor straight away, or go straight to the Emergency Department at your nearest hospital if you notice any of these serious side effects.

Tell your doctor or pharmacist if you notice anything else that may be making you feel unwell.

Other side effects not listed here may occur in some people. Children and people over 65 years if age may have an increased chance of getting side effects.

Reporting side effects

After you have received medical advice for any side effects you experience, you can report side effects to the Therapeutic Goods Administration online at www.tga.gov.au/reporting-problems. By reporting side effects, you can help provide more information on the safety of this medicine.

7. Product details

This medicine is available over-the-counter without a doctor's prescription.

What CODRAL Original Day & Night contains

Day Tablets

Active ingredient
(main ingredient)
Paracetamol
Pseudoephedrine hydrochloride
Other ingredients
(inactive ingredients)
Ethanol
Hyprolose
Magnesium stearate
Microcrystalline cellulose
Pregelatinized maize starch
Purified water
Sodium starch glycollate
Stearic Acid

Night Tablets

Active ingredient
(main ingredient)
Paracetamol
Pseudoephedrine hydrochloride
Triprolidine hydrochloride
Other ingredients
(inactive ingredients)
Brilliant blue FCF
Ethanol
Hyprolose
Magnesium stearate
Microcrystalline cellulose
Povidone
Purified water
Quinoline yellow

Do not take this medicine if you are allergic to any of these ingredients.

What CODRAL Original Day & Night looks like

Day tablets are white, round, flat tablets with wide bevelled edges. Scored and coded "P3F" on the face. Plain on the other face.

Night tablets are turquoise, bevelled, capsule-shaped, flat tablets. Scored on one face and coded "S3F" each side of the score. Plain on the other face.

(Aust R 275261).

Who distributes CODRAL Original Day & Night

Johnson & Johnson Pacific
45 Jones Street
Ultimo NSW 2007
Australia
Phone: 1800 029979

This leaflet was prepared in January 2022.

Published by MIMS June 2022

BRAND INFORMATION

Brand name

Codral Original Day & Night

Active ingredient

Paracetamol; Pseudoephedrine hydrochloride; Triprolidine hydrochloride

Schedule

S3

 

1 Name of Medicine

Paracetamol.
Pseudoephedrine hydrochloride.
Triprolidine hydrochloride.

2 Qualitative and Quantitative Composition

Codral Original Day & Night tablets contain two separate formulations: day tablets and night tablets.
Each Codral Original Day & Night day tablet contains pseudoephedrine hydrochloride 30 mg, paracetamol 500 mg.
For the full list of excipients, see Section 6.1 List of Excipients.
Each Codral Original Day & Night night tablet contains pseudoephedrine hydrochloride 30 mg, paracetamol 500 mg, triprolidine hydrochloride 1.25 mg.
For the full list of excipients, see Section 6.1 List of Excipients.

3 Pharmaceutical Form

Codral Original Day & Night day tablets are white, round, flat and uncoated with wide bevelled edges. They are scored and coded 'P3F' on one face, and the other face is plain.
Codral Original Day & Night night tablets are turquoise, bevelled, capsule-shaped, flat and uncoated. They are scored on one face and coded 'S3F' each side of the score, and plain on the other face.

4 Clinical Particulars

4.1 Therapeutic Indications

Codral Original Day & Night provides temporary relief from the symptoms of colds and flu. "Day" tablet relieves runny nose, nasal congestion, headache, body aches and pains, and fever. "Night" tablet relieves runny nose, pain, fever, headache and sneezing.

4.2 Dose and Method of Administration

The recommended dosage of Codral Original Day & Night for adults and children 12 years and over is:
Day - take 2 day tablets in the morning and 2 tablets in the afternoon;
Night - take 2 night tablets in the evening at bedtime.
Codral Original Day & Night should not to be taken by children under 12 years of age.

Use in adults.

Paracetamol should not be taken for more than a few days at a time except on medical advice.

Use in children.

Paracetamol should not be taken for more than 48 hours except on medical advice.

4.3 Contraindications

Pseudoephedrine is contraindicated for use in patients:
with known hypersensitivity or idiosyncratic reaction to pseudoephedrine (or any of the other ingredients in the product);
with severe hypertension or coronary artery disease;
taking monoamine oxidase inhibitors (MAOIs) or who have taken MAOIs within the previous 14 days.
Paracetamol is contraindicated for use in patients with known hypersensitivity or idiosyncratic reaction to paracetamol (or any of the other ingredients in the product). Use of the product should be discontinued at the first appearance of a skin rash or any other sign of hypersensitivity.
Triprolidine is contraindicated for use in patients with:
a history of hypersensitivity to the substance or substances of similar chemical structure (or any of the other ingredients in the product);
narrow-angle glaucoma;
stenosing peptic ulcer;
symptomatic prostatic hypertrophy;
bladder neck obstruction;
pyloroduodenal obstruction.
Triprolidine is contraindicated for use in:
newborns or premature infants;
lactating women;
patients taking monoamine oxidase inhibitors (MAOIs).
See Section 4.5 Interactions with Other Medicines and Other Forms of Interactions for additional information.

4.4 Special Warnings and Precautions for Use

Pseudoephedrine should be used with caution in patients with hypertension, hyperthyroidism or thyroid disease, diabetes mellitus, coronary heart disease, ischaemic heart disease, glaucoma, prostatic hypertrophy, severe hepatic or renal dysfunction.
Some cases of ischaemic colitis have been reported with pseudoephedrine.
Pseudoephedrine should be discontinued and medical advice sought if sudden abdominal pain, rectal bleeding or other symptoms of ischaemic colitis develop.
If signs and symptoms such as formation of small pustules occur, with or without pyrexia or erythema, then treatment with pseudoephedrine should be discontinued and a physician should be consulted.
Paracetamol should be used with caution in patients with impaired hepatic function, impaired renal function, chronic alcoholism.
Triprolidine may cause drowsiness and may increase the effects of alcohol. Drowsiness may continue the following day. Those affected should not drive or operate machinery; alcohol should be avoided.
Use with caution in patients with renal or hepatic impairment and in patients with epilepsy, and in patients with respiratory conditions such as emphysema, chronic bronchitis, or acute or chronic bronchial asthma.
See Section 4.5 Interactions with Other Medicines and Other Forms of Interactions for additional information.

Use in elderly.

The elderly may experience paradoxical excitation with triprolidine. The elderly are more likely to have CNS depressive side effects, including confusion.

Paediatric use.

Children may experience paradoxical excitation with triprolidine.

Effects on laboratory tests.

No data available.

4.5 Interactions with Other Medicines and Other Forms of Interactions

The following interactions with pseudoephedrine have been noted:
antidepressant medication e.g. tricyclic antidepressants and monoamine oxidase inhibitors (MAOIs) - may cause a serious increase in blood pressure or hypertensive crisis;
other sympathomimetic agents, such as decongestants, appetite suppressants and amphetamine-like psychostimulants - may cause an increase in blood pressure and additive effects;
methyldopa and β-blockers - may cause an increase in blood pressure;
urinary acidifiers enhance elimination of pseudoephedrine;
urinary alkalinisers decrease elimination of pseudoephedrine.
The following interactions with paracetamol have been noted:
anticoagulant drugs (warfarin) - dosage may require reduction if paracetamol and anticoagulants are taken for a prolonged period of time;
paracetamol absorption is increased by substances that increase gastric emptying, e.g. metoclopramide;
paracetamol absorption is decreased by substances that decrease gastric emptying, e.g. propantheline, antidepressants with anticholinergic properties, and narcotic analgesics;
paracetamol may increase chloramphenicol concentrations;
the risk of paracetamol toxicity may be increased in patients receiving other potentially hepatotoxic drugs or drugs that induce liver microsomal enzymes such as alcohol and anticonvulsant agents;
paracetamol excretion may be affected and plasma concentrations altered when given with probenecid;
colestyramine reduces the absorption of paracetamol if given within 1 hour of paracetamol.
high anion gap metabolic acidosis from pyroglutamic acid (5-oxoprolinemia) has been reported with concomitant use of therapeutic doses of paracetamol and flucloxacillin. Patients reported to be most at risk are elderly females with underlying disease such as sepsis, renal function abnormality, and malnutrition.
The following interactions with triprolidine have been noted:
CNS depressants (alcohol, sedatives, opioid analgesics, hypnotics) - may cause an increase in sedation effects;
monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs) - may prolong and intensify the anticholinergic and CNS depressive effects.

4.6 Fertility, Pregnancy and Lactation

Effects on fertility.

No data available.
(Category B2)
The pregnancy categorisation is B2. Pseudoephedrine has been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human foetus having been observed. Studies in animals are inadequate or may be lacking, but available data shows no evidence of an increased occurrence of foetal damage.
Pseudoephedrine should be used in pregnancy only if the potential benefits to the patient are weighed against the possible risk to the foetus.
Paracetamol has been taken by a large number of pregnant women and women of childbearing age without any proven increase in the frequency of malformations or other direct or indirect harmful effects on the foetus having been observed.
Triprolidine has been taken by a large number of pregnant women and women of childbearing age without any proven increase in the frequency of malformations or other direct or indirect harmful effects on the foetus having been observed.
Pseudoephedrine is secreted in breast milk in small amounts. It has been estimated that 0.5% to 0.7% of a single dose of pseudoephedrine ingested by the mother will be excreted in the breast milk over 24 hours. Therefore, it is not recommended for breastfeeding mothers unless the potential benefits to the patient are weighed against the possible risk to the infant.
Paracetamol is excreted in small amounts (< 0.2%) in breast milk. Maternal ingestion of paracetamol in usual analgesic doses does not appear to present a risk to the breastfed infant.
Triprolidine is excreted in breast milk. Therefore, it is not recommended for breastfeeding mothers unless the potential benefits to the patient are weighed against the possible risk to the infant.

4.7 Effects on Ability to Drive and Use Machines

Triprolidine may cause drowsiness and may increase the effects of alcohol. Drowsiness may continue the following day. Those affected should not drive or operate machinery; alcohol should be avoided.

4.8 Adverse Effects (Undesirable Effects)

Adverse drug reactions identified during postmarketing experience are detailed in Table 1. Additionally, the following should be noted.
Adverse effects of pseudoephedrine include elevated blood pressure.
Children and the elderly are more likely to experience adverse effects than other age groups.
Side effects of paracetamol are rare and usually mild, although haematological reactions have been reported. Overdosage with paracetamol if left untreated can result in severe, sometimes fatal liver damage and rarely, acute renal tubular necrosis.
CNS depressive effects of triprolidine include sedation and impaired performance (impaired driving performance, poor work performance, incoordination, reduced motor skills and impaired information processing). Performance may be impaired in the absence of sedation and may persist the morning after a night time dose.
CNS stimulatory effects of triprolidine may include appetite stimulation, muscle dyskinesias and activation of epileptogenic foci.
High doses of triprolidine may cause agitation and irritability.
Side effects of triprolidine associated with cholinergic blockage include dryness of the eyes, mouth and nose, blurred vision, urinary hesitancy and retention, constipation and tachycardia.
Adverse drug reactions identified during postmarketing experience with paracetamol, pseudoephedrine, the combination of pseudoephedrine and triprolidine, the combination of pseudoephedrine and paracetamol or the combination paracetamol, pseudoephedrine and triprolidine appear in Table 1. The frequency category was estimated from spontaneous reporting rates.
Adverse events that have been observed during clinical trials and/or post-marketing use are ranked under the following frequency: Very common (> 1/10); common (> 1/100, < 1/10); uncommon (> 1/1000, < 1/100); rare (> 1/10,000, < 1/1000); very rare (< 1/10,000 and including isolated reports).

Reporting suspected adverse effects.

Reporting suspected adverse reactions after registration of the medicinal product is important. It allows continued monitoring of the benefit-risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions at www.tga.gov.au/reporting-problems.

4.9 Overdose

If an overdose is taken or suspected, immediately contact the Poisons Information Centre (in Australia, call 13 11 26; in New Zealand call 0800 764 766) for advice, or go to a hospital straight away even if you feel well because of the risk of delayed, serious liver damage.
Overdosage with paracetamol if left untreated can result in severe, sometimes fatal liver damage, and rarely, acute renal tubular necrosis.

5 Pharmacological Properties

5.1 Pharmacodynamic Properties

Mechanisms of action.

Pseudoephedrine has direct and indirect sympathomimetic activity and is an effective decongestant in the upper respiratory tract. It is a stereoisomer of ephedrine and has a similar action, but has been found to have less pressor activity and fewer central nervous system (CNS) effects.
Sympathomimetic agents are used as nasal decongestants to provide symptomatic relief. They act by causing vasoconstriction resulting in redistribution of local blood flow to reduce oedema of the nasal mucosa, thus improving ventilation, drainage and nasal stuffiness.
Paracetamol is a p-aminophenol derivative that exhibits analgesic and antipyretic activity. It does not possess anti-inflammatory activity. Paracetamol is thought to produce analgesia through a central inhibition of prostaglandin synthesis.
Triprolidine competes with histamine at central and peripheral histamine1-receptor sites, preventing the histamine-receptor interaction and subsequent mediator release.
Triprolidine is a highly lipophilic molecule that readily crosses the blood-brain barrier.
Triprolidine is highly selective for histamine1-receptors but has little effect on histamine2 or histamine3 receptors. Triprolidine also activates 5-hydroxytryptamine (serotonin) and α-adrenergic receptors and blocks cholinergic receptors.

Clinical trials.

No data available.

5.2 Pharmacokinetic Properties

Pseudoephedrine is readily absorbed from the gastrointestinal tract. It is largely excreted unchanged in the urine together with small amounts of its hepatic metabolite. It has a half-life of about 5-8 hours; elimination is enhanced and half-life reduced accordingly in acid urine. Small amounts are distributed into breast milk.
Paracetamol is readily absorbed from the gastrointestinal tract with peak plasma concentrations occurring about 10 to 60 minutes after oral administration. Paracetamol is distributed into most body tissues. Plasma protein binding is negligible at usual therapeutic doses but increases with increasing doses. The elimination half-life varies from about 1 to 3 hours.
Paracetamol is metabolised extensively in the liver and excreted in the urine mainly as inactive glucuronide and sulfate conjugates. Less than 5% is excreted unchanged. The metabolites of paracetamol include a minor hydroxylated intermediate which has hepatotoxic activity. This intermediate metabolite is detoxified by conjugation with glutathione; however, it can accumulate following paracetamol overdosage (more than 150 mg/kg or 10 g total paracetamol ingested) and if left untreated can cause irreversible liver damage.
Paracetamol is metabolised differently by premature infants, newborns, infants and young children compared to adults, the sulfate conjugate being predominant.
After absorption from the gastro-intestinal tract, triprolidine hydrochloride is metabolised; a carboxylated derivative accounts for about half the dose excreted in the urine. Reported half-lives vary from 3 to 5 hours or more. Triprolidine is distributed into breast milk.

5.3 Preclinical Safety Data

Genotoxicity.

No data available.

Carcinogenicity.

No data available.

6 Pharmaceutical Particulars

6.1 List of Excipients

Each Codral Original Day & Night day tablet contains the excipients: microcrystalline cellulose, hydroxypropylcellulose, magnesium stearate, sodium starch glycollate, pregelatinised wheat starch, stearic acid.
Each Codral Original Day & Night night tablet contains the excipients: brilliant blue FCF, microcrystalline cellulose, hydroxypropylcellulose, magnesium stearate, povidone, quinoline yellow.

6.2 Incompatibilities

Incompatibilities were either not assessed or not identified as part of the registration of this medicine. See Section 4.5 Interactions with Other Medicines and Other Forms of Interactions.

6.3 Shelf Life

3 Years.

6.4 Special Precautions for Storage

Store below 25°C. Keep in a dry dark place.

6.5 Nature and Contents of Container

Codral Original Day & Night tablets are available in blister packs of the following sizes: 24 tablets (S3) Pharmacist Only Medicine.

6.6 Special Precautions for Disposal

In Australia, any unused medicine or waste material should be disposed of in accordance with local requirements.

6.7 Physicochemical Properties

Chemical structure.


CAS number.

Paracetamol.

CAS Registry Number: 103-90-2.

Pseudoephedrine hydrochloride.

CAS Registry Number: 345-78-8.

Triprolidine hydrochloride.

CAS Registry Number: 6138-79-0.

7 Medicine Schedule (Poisons Standard)

Schedule 3.

Summary Table of Changes