SUMMARY CMI
Pexsig
Consumer Medicine Information (CMI) summary
The full CMI on the next page has more details. If you are worried about using this medicine, speak to your doctor or pharmacist.
1. Why am I using PEXSIG?
PEXSIG contains the active ingredient perhexiline maleate. It is used to reduce the frequency of moderate to severe attacks of angina pectoris (severe chest pain caused by heart disease)
For more information, see Section 1. Why am I using PEXSIG? in the full CMI.
2. What should I know before I use PEXSIG?
Do not use if you have ever had an allergic reaction to perhexiline or any of the ingredients listed at the end of the CMI.
Talk to your doctor if you have any other medical conditions, take any other medicines, or are pregnant or plan to become pregnant or are breastfeeding.
For more information, see Section 2. What should I know before I use PEXSIG? in the full CMI.
3. What if I am taking other medicines?
Some medicines may interfere with PEXSIG and affect how it works.
A list of these medicines is in Section 3. What if I am taking other medicines? in the full CMI.
4. How do I use PEXSIG?
- The dose will be decided by your doctor and will depend on your condition and how you respond to PEXSIG. A common starting dose is 1 tablet taken once or twice a day. It may be decreased or increased every 2 to 4 weeks depending on your response, to a maximum of 3 tablets a day in divided doses, or 4 tablets in rare cases.
- PEXSIG tablets should be swallowed whole with a glass of water.
More instructions can be found in Section 4. How do I use PEXSIG? in the full CMI.
5. What should I know while using PEXSIG?
Things you should do |
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Things you should not do |
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Driving or using machines |
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Drinking alcohol |
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Looking after your medicine |
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For more information, see Section 5. What should I know while using PEXSIG? in the full CMI.
6. Are there any side effects?
Common side effects of PEXSIG include: dizziness or drunken sensation; difficulty in/or changed walking; unsteadiness; nausea; vomiting; headache; lack of appetite and moderate weight loss (2‐4kg); temporary increases in blood substances from the liver; increases in blood fats; moderate decreases in blood sugar; and alterations to the ECG (the electrical record of heart activity). Serious side effects of PEXSIG include: inflammation of nerve roots of the skin and spine accompanied by fever; loss of appetite and significant weight loss (>10% of body weight); severe lack of sugar in blood; and liver disease.
For more information, including what to do if you have any side effects, see Section 6. Are there any side effects? in the full CMI.
FULL CMI
Pexsig
Active ingredient(s): Perhexiline maleate
Consumer Medicine Information (CMI)
This leaflet provides important information about using PEXSIG. You should also speak to your doctor or pharmacist if you would like further information or if you have any concerns or questions about using PEXSIG.
Where to find information in this leaflet:
1. Why am I using PEXSIG?
2. What should I know before I use PEXSIG?
3. What if I am taking other medicines?
4. How do I use PEXSIG?
5. What should I know while using PEXSIG?
6. Are there any side effects?
7. Product details
1. Why am I using PEXSIG?
PEXSIG contains the active ingredient perhexiline maleate. It belongs to a group of medicines called anti‐anginal agents.
These are used to reduce the frequency of moderate to severe attacks of angina pectoris (severe chest pain caused by heart disease). PEXSIG acts by increasing the efficiency of the heart.
Only take PEXSIG when your doctor prescribes it for you.
Ask your doctor if you have any questions about why PEXSIG has been prescribed for you.
If you have any concerns you should discuss this with your doctor.
This medicine is available only with a doctor's prescription.
2. What should I know before I use PEXSIG?
Warnings
Do not use PEXSIG if:
- You are allergic to perhexiline maleate, or any of the ingredients listed at the end of this leaflet.
- Some symptoms of an allergic reaction may include shortness of breath, wheezing or difficulty in breathing; swelling of the face, lips, tongue, or any other parts of the body; rash, itching or hives on the skin.
- Always check the ingredients to make sure you can use this medicine. Check with your doctor or pharmacist if you are unsure. - You have or have had any of the following medical conditions:
- Kidney or liver disease - The expiry date printed on the pack has passed.
- The packaging is torn or shows signs of tampering.
Check with your doctor if you:
- Have any other medical conditions, especially the following:
- Diabetes
If you use insulin or take a certain type of antidiabetic tablet you may need to adjust your dosage during the first few days after starting on PEXSIG.
- Kidney or liver disease. - Take any medicines for any other condition.
- Have had any allergy to any other medicines, or any other substances, such as foods, preservatives, or dyes.
During treatment, you may be at risk of developing certain side effects. It is important you understand these risks and how to monitor for them. See additional information under Section 6. Are there any side effects?
Pregnancy and breastfeeding
Check with your doctor if you are pregnant or intend to become pregnant. As there is no experience with the use of PEXSIG in pregnant women, your doctor must weigh the potential benefits against the possible risks.
Do not take his medicine if you are breastfeeding or intend to breastfeed.
Use in children
This medicine should not be used in children.
3. What if I am taking other medicines?
Tell your doctor or pharmacist if you are taking any other medicines, including any medicines, vitamins or supplements that you buy without a prescription from your pharmacy, supermarket or health food shop.
Some medicines may interfere with PEXSIG and affect how it works. These include:
- Beta‐blockers e.g. propranolol, metoprolol – a group of medicines used for heart conditions and high blood pressure.
- If your doctor wants you to stop taking these, it should be withdrawn gradually over several days. - Anti‐diabetic medications (used to treat diabetes)
Check with your doctor or pharmacist if you are not sure about what medicines, vitamins or supplements you are taking and if these affect PEXSIG.
4. How do I use PEXSIG?
How much to take
- The dose will be decided by your doctor and will depend on your condition and how you respond to PEXSIG.
- A common starting dose is one PEXSIG tablet taken once or twice a day; your doctor may increase or decrease this dose at intervals, usually 2 to 4 weeks, based on the results obtained.
- Generally, the dose should not exceed three PEXSIG tablets a day in divided doses. In some cases, a dose of 4 PEXSIG tablets per day may be necessary.
- Do NOT take more tablets than your doctor has prescribed.
- Some patients may require a lower dose than the 100 mg contained in PEXSIG tablets; in this case, PEXSIG tablets can be broken in half, giving 50 mg in each half tablet.
When to take it
- If your doctor has prescribed you more than one PEXSIG tablet per day, you will take them in divided doses as directed by your doctor.
For example, if you have been prescribed two tablets per day, your doctor would probably direct you to take one tablet in the morning and one in the evening. - Follow the directions on the pharmacist's label on the pack.
How to take it
- PEXSIG tablets should be swallowed whole with a glass of water.
How long to take it for
- PEXSIG controls your condition but does not cure it. Therefore, PEXSIG should be taken every day for as long as your doctor has prescribed it.
If you forget to use it
Take it as soon as you remember and then go back to taking it as you would normally.
If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.
Do not take a double dose to make up for the dose you missed.
If you take too much
If you think that you have used too much PEXSIG, you may need urgent medical attention.
You should immediately:
- phone the Poisons Information Centre
(by calling 13 11 26), or - contact your doctor, or
- go to the Emergency Department at your nearest hospital.
You should do this even if there are no signs of discomfort or poisoning.
If you accidentally take too many tablets, you will likely have the following symptoms:
- Nausea
- Vomiting
- Unsteady walking
- Headache
More severe symptoms, for example, liver damage or irregular or rapid heartbeat, may develop. Damage to the liver could occur.
5. What should I know while using PEXSIG?
Things you should do
Tell any other doctors, dentists and pharmacists who are treating you that you are using PEXSIG.
Visit your doctor regularly. Your doctor will want to regularly examine you (at least once a month) to see how you are responding to the medication and check if they need to adjust the dose or stop the medication.
If you need to have any medical tests while you are taking PEXSIG tell your doctor. PEXSIG may affect the results of some tests.
Call your doctor straight away if you:
- Become pregnant while taking PEXSIG.
Things you should not do
Do not give PEXSIG to anyone else, even if their symptoms seem similar or they have the same condition as you.
Do not take PEXSIG to treat any other complaints unless your doctor tells you to.
Do not stop taking PEXSIG or change the dose even if you are feeling better, without checking with your doctor.
Driving or using machines
Be careful before you drive or use any machines or tools until you know how PEXSIG affects you.
PEXSIG may cause dizziness or unsteadiness in some people.
Drinking alcohol
Tell your doctor if you drink alcohol.
Looking after your medicine
- Keep PEXSIG tablets in a cool dry place, away from light where the temperature stays below 30°C.
For example, do not store it:
- In the bathroom or near a sink, or
- In the car or on window sills
Heat and dampness can destroy some medicines.
Follow the instructions in the carton on how to take care of your medicine properly.
Keep it where young children cannot reach it.
A locked cupboard at least one and a half metres above the ground is a good place to store medicines.
Getting rid of any unwanted medicine
If you no longer need to use this medicine or it is out of date, take it to any pharmacy for safe disposal.
Do not use this medicine after the expiry date.
6. Are there any side effects?
All medicines can have side effects. If you do experience any side effects, most of them are minor and temporary. However, some side effects may need medical attention.
See the information below and, if you need to, ask your doctor or pharmacist if you have any further questions about side effects.
Less serious side effects
Less serious side effects | What to do |
More common
| Speak to your doctor if you have any of these less serious side effects. |
Serious side effects
Serious side effects | What to do |
Signs of inflammation of nerve roots of the skin and spine, and accompanied by fever:
| Call your doctor straight away, or go straight to the Emergency Department at your nearest hospital if you notice any of these serious side effects. |
Most side effects of PEXSIG usually occur in the first few weeks of treatment, and some may disappear in 2 to 4 weeks. More often they go away if the dose is reduced. In some cases they only go away if the treatment is stopped.
Tell your doctor or pharmacist if you notice anything else that may be making you feel unwell.
Other side effects not listed here may occur in some people.
Reporting side effects
After you have received medical advice for any side effects you experience, you can report side effects to the Therapeutic Goods Administration online at www.tga.gov.au/reporting-problems. By reporting side effects, you can help provide more information on the safety of this medicine.
Always make sure you speak to your doctor or pharmacist before you decide to stop taking any of your medicines.
7. Product details
This medicine is only available with a doctor's prescription.
What PEXSIG contains
Active ingredient (main ingredient) | Perhexiline maleate 100mg |
Other ingredients (inactive ingredients) | Lactose monohydrate Maize starch Sucrose Purified talc |
Potential allergens | Lactose Sucrose |
Do not take this medicine if you are allergic to any of these ingredients.
What PEXSIG looks like
A white to off‐white tablet scored on one side. It is supplied in amber glass bottles containing 100 tablets.
(AUST R 52182)
Who distributes PEXSIG
Aspen Pharmacare Australia Pty Ltd
34‐36 Chandos St
St Leonards NSW 2065
Australia
This leaflet was revised in November 2024
Published by MIMS February 2025