Consumer medicine information

Aeris Medical E.P. Grade Compressed Oxygen

Oxygen

BRAND INFORMATION

Brand name

Aeris Medical E.P. Grade Compressed Oxygen

Active ingredient

Oxygen

Schedule

Unscheduled

What is in this leaflet

This leaflet answers some common questions about Aeris Medical (Aeris) Medical Oxygen.

It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist.

All medicines have risks and benefits. Your doctor has weighed the risks of you taking Aeris Medical Oxygen against the benefits they expect it will have for you.

If you have any concerns about taking this medicine, ask your doctor or pharmacist.

Keep this leaflet. You may need to read it again.

What Aeris Medical Oxygen is used for

Aeris Medical Oxygen is for use only by or under the supervision of qualified medical practitioners.

This medicine is used to increase supply of oxygen and treat a shortage of oxygen in the body.

Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed it for another reason.

Before you use Aeris Medical Oxygen

Taking other medicines

Tell your doctor or pharmacist if you are taking any other medicines, including any that you get without a prescription from your pharmacy, supermarket or health food shop. Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking this medicine.

Do not use oxygen near naked flame or equipment that may spark. Oxygen increases the risk of fire.

Do not smoke when using oxygen.

If you cannot stop smoking, you may not be able to use oxygen, because of the risk of fires and severe burns.

Ensure your hands are clean and free from oil or grease before using.

How to use Aeris Medical Oxygen

Read and follow all the safety directions and instructions for use provided with the oxygen cylinder.

Follow all directions given to you by your doctor or pharmacist carefully. They may differ from the information contained in this leaflet.

If you do not understand the instructions, ask your doctor or pharmacist for help.

How much to use

Use the concentration prescribed by your doctor.

How to use it

Use regulator and equipment compatible with contents and pressure.

Do not open cylinder valve unless an appropriate authorised pressure- reducing device is attached to the cylinder valve. The cylinder valve is not a metering device.

Open valve slowly and shut after use.

Inhale using a mask, cannula or catheter.

Keep and use in a well-ventilated secure area.

Do not smoke when using.

When to use it

Use as prescribed by your doctor.

How long to use it

Continue taking your medicine for as long as your doctor tells you.

If you forget to use it

Use it as soon as you remember, and then go back to taking your medicine as you would normally.

Do not use a double dose to make up for the dose that you missed.

If you are not sure what to do, ask your doctor or pharmacist.

If you have trouble remembering to use your medicine, ask your pharmacist for some hints.

If you use too much (overdose)

Immediately telephone your doctor or the Poisons Information Centre (telephone 13 11 26) for advice, or go to the Accident and Emergency at the nearest hospital, if you think that you or anyone else may have used too much Aeris Medical Oxygen. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.

Your doctor has prescribed for you the concentration of oxygen for you to breathe. Concentrations higher than recommended, over a long time, may have some harmful effects.

Symptoms of an overdose may include

Soreness or tightness in the chest, coughing or breathing difficulties
Drowsiness

While you are using Aeris Medical Oxygen

Things you must do

If you are about to be started on any new medicine, remind your doctor and pharmacist that you are using this medicine.

Tell any other doctors, dentists, and pharmacists who treat you that you are taking this medicine.

If you are going to have surgery, tell the surgeon or anaesthetist that you are taking this medicine. It may affect other medicines used during surgery.

If you are about to have any blood tests, tell your doctor that you are taking this medicine. It may interfere with the results of some tests.

Use only saline nasal sprays or water-based lubricants to treat nasal stuffiness or dryness caused by oxygen treatment through nasal tubing.

Things you must not do

Do not use this medicine to treat any other complaints unless your doctor tells you to.

Do not give your medicine to anyone else, even if they have the same condition as you.

Do not stop taking your medicine or lower the dosage without checking with your doctor. If you stop taking it suddenly, your condition may worsen. If possible, your doctor will gradually reduce the amount you use each day before stopping the medicine completely.

Never use as a substitute for compressed air.

Do not smoke.

Do not use near naked flame.

Do not use oil or grease on any part of the equipment.

Do not use oil-based moisturiser when using a facemask or nasal tubing.

Things to be careful of

If you feel light-headed, dizzy or faint when getting out of bed or standing up, get up slowly. Standing up slowly, especially when you get up from bed or chairs, will help your body get used to the change in position and blood pressure. If this problem continues or gets worse, talk to your doctor.

Do not use near equipment or material that may spark or cause fire.

Tell your doctor if you want to drive a car or operate machinery. Your doctor will assess your fitness to drive. While oxygen therapy is not expected to affect your ability to drive a car or operate machinery, oxygen must not be used near equipment or material that may spark or cause fire.

Check with your doctor or pharmacist before using a moisturiser with a facemask or in the nose.

Side effects

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are using Aeris Medical Oxygen.

Tell your doctor or pharmacist if you notice any of the following and they worry you:

problems with vision
dryness, irritation or pain in the ear, nose or throat
drowsiness
chest tightness, dry cough, pain when breathing
nausea

If using nasal tubing, nasal symptoms such as nasal stuffiness, dryness or bleeding are common.

Ask your doctor or pharmacist to answer any questions you may have.

After using Aeris Medical Oxygen

Storage

Keep your oxygen cylinder in a cool dry place where the temperature stays below 30°C.

Keep the oxygen cylinder where children cannot reach it.

Store away from combustible, flammable, oily, greasy and tarry materials.

Do not apply any oily, greasy substances to any part of the cylinder, valve or any attached devices.

Do not heat cylinder.

Disposal

If your doctor tells you to stop using this medicine or the expiry date has passed, return the oxygen cylinder to the place where you bought it.

Product description

What it looks like

Aeris Medical Oxygen is a colourless, odourless gas contained in a metal cylinder that has a black body and a white shoulder, which is the Australian Standard colour coding for medical grade oxygen. All medical oxygen cylinders contain high pressure and should only be used in conjunction with an authorised mask and pressure- reducing device attached to control the rate of oxygen flow.

Ingredients

Aeris Medical Oxygen contains 100% oxygen as the active ingredient.

There are no other ingredients.

Manufacturer

Aeris Medical Medical Oxygen is manufactured in Australia by:

Supagas Pty Ltd
23 Commercial Drive, Dandenong South VIC 3175

This leaflet was prepared in July 2012. This leaflet was formatted October 24^th 2017.

AUST R 135847

Published by MIMS November 2019

BRAND INFORMATION

Brand name

Aeris Medical E.P. Grade Compressed Oxygen

Active ingredient

Oxygen

Schedule

Unscheduled

1 Name of Medicine

Oxygen.

2 Qualitative and Quantitative Composition

Each gas cylinder contains oxygen 100% v/v.

3 Pharmaceutical Form

Medicinal gas.
Odourless, colourless gas.

4 Clinical Particulars

4.1 Therapeutic Indications

Oxygen for medical use.
To increase supply of oxygen to the lungs.
For respiratory support where there is a requirement for medical oxygen to treat or prevent hypoxemia.

4.2 Dose and Method of Administration

Oxygen is administered by inhalation through the lungs. The major exception is when a metered supply is fed into the oxygenator of an extracorporeal circulation of a cardio-pulmonary by-pass system.

Dosage.

Inhaled medical oxygen must be administered using an appropriate pressure reduction device and equipment such as mask or nasal prongs to deliver the required inspired concentration of oxygen, between 21% and 100%, as determined by the prescriber after full clinical assessment. Most delivery systems for adults result in an inspired oxygen concentration of 60% or less.
Inhaled oxygen may require humidification when treatment duration is longer than an hour. Nasal symptoms, such as nasal stuffiness, dryness or bleeding may be alleviated by the use of nasal saline sprays or water-based lubricant.
Standard texts and clinical protocols should be consulted for the oxygen requirements specific to the underlying condition and the clinical status of the individual patient. It is essential to monitor ventilation, arterial oxygen saturation, and the clinical effect of the treatment.
In general, the aim of treatment is to ensure that the oxygen partial pressure in arterial blood (PaO₂) does not fall below 60 mmHg or that the oxygen saturation of haemoglobin in arterial blood does not fall below 90%, by adjusting the oxygen fraction in the inhaled air (FiO₂). The dose (FiO₂) must be adjusted according to each patient's individual needs, taking into account the risk of oxygen toxicity. The general recommendation is to use the lowest dose necessary to achieve the desired result of treatment.
In cases of pronounced hypoxia, oxygen fractions that can involve a risk of oxygen toxicity may be indicated (see Section 4.9 Overdose).
In short-term treatment with oxygen, the oxygen concentration i.e. the fraction in the inhaled gas mixture (FiO₂; avoid > 0.6 = 60% O₂ in the inhaled gas mixture) should be maintained so as to achieve an arterial oxygen partial pressure (PaO₂) > 60 mmHg.
In patients with chronic respiratory disorders with hypercapnia there is a risk of reduced respiratory drive with high oxygen concentrations, and low controlled oxygen concentrations (24%-28%) are generally used at commencement, with incremental increases based on individual clinical assessment.
Treatment of neonates with oxygen may be required but must be strictly monitored, so that the oxygen concentration may be reduced when the patient's condition allows. For neonates (full-term and preterm) the appropriate institutional protocols, based on full clinical assessment, should be followed.
In the emergency/acute setting the usual dose for adults to treat or prevent acute oxygen deficiency is 3-4 litres per minute when using nasal prongs or 5-15 litres per minute with a mask.
Oxygen treatment must be continuously evaluated and the effect measured by means of PaO₂ or arterial oxygen saturation.
The use of medical oxygen for hyperbaric oxygen treatment is beyond the scope of this Registered Therapeutic Good. See specialist literature.

Handling and instructions for use.

Warning: medical oxygen increases burning and the risk of fire.
Do not use medical oxygen if:
a. you are smoking;
b. you are near open flames.
Cylinders must be fitted with an appropriate pressure-reducing device; see Section 4.4 Special Warnings and Precautions for Use.
Consult the information provided by the sponsor about operating procedures for the cylinders.
Do not use medical oxygen if the cylinder is damaged or has the tamper evident plastic seal removed.
All personnel handling medical oxygen should have adequate knowledge of:
properties of the gas;
correct operating procedures for the cylinder;
precautions and actions to be taken in the event of an emergency.
Under no circumstances should oils or grease be used to lubricate any part of the compressed gas medical oxygen cylinder or the associated equipment used to deliver the gas to the patient. Always ensure hands are clean and free from any oils or grease.
Where moisturizing preparations are required for use with a facemask or in nasal passages etc., avoid using oil based creams. If in doubt, check with the manufacturer to ensure that the product of choice is suitable for use with oxygen.
When compressed medical oxygen cylinders are in use, ensure that they are:
only used for medicinal purposes;
only moved with the appropriate size and type of trolley or handling device;
handled with care and not knocked violently or allowed to fall;
firmly secured to a suitable cylinder support when in use;
not used in the vicinity of persons smoking or near naked lights.
When the compressed medical oxygen cylinder is empty ensure that:
the cylinder valve is closed using moderate force only and the pressure in the regulator or tailpipe released, and the valve outlet cap, where fitted, is replaced;
empty cylinders are immediately returned to the empty cylinder store for return to the supplier.

4.3 Contraindications

Domiciliary oxygen therapy is not indicated for adult patients with severe airflow limitation whose main complaint is dyspnoea but who maintain a PaO₂ > 60 mmHg and who show no secondary effects of chronic hypoxia, or who have not received adequate therapy of other kinds (e.g. bronchodilators and corticosteroids, treatment for right ventricular failure, or for any respiratory infection).
Domiciliary oxygen should generally not be used by patients who continue to smoke cigarettes, due to the increased risk of fire. See Section 4.4 Special Warnings and Precautions for Use.

4.4 Special Warnings and Precautions for Use

General.

Warning: oxygen aids and increases combustion. Oxygen strongly supports combustion. Smoking is prohibited and no naked flame is allowed.
Oxygen when in contact with oils, greases, tarry substances and many plastics is highly dangerous due to the risk of spontaneous combustion with high-pressure gases.
Electrical equipment capable of sparking or generating extreme heat should not be used in the vicinity of patients receiving oxygen.

Check the following before use.

Oxygen cylinders must be fitted with an appropriate and lawfully supplied pressure-reducing device dedicated to use with medical oxygen and complying with Australian Standards (see Section 4.2 Dose and Method of Administration, Handling and instructions for use). Where this device is separate, it must match the cylinder valve pin index outlet. Where the dispensing equipment connection is separate, this must be connected by an oxygen-specific coupling.
Cylinder pressure may be used as an indicator of the quantity of gas remaining in the cylinder.

Use of gas cylinders.

The normal precautions required for the storage and use of medical gas cylinders are applicable. Because the contents are under pressure and are sometimes hazardous, there are special safety regulations for handling cylinders of gases. These include chaining cylinders to prevent falling and breaking, proper ventilation to prevent injury or death in case of leaks and signage to indicate the potential hazards. Installing and replacing gas cylinders should be done by trained personnel.
Under no circumstances should oils or grease be used to lubricate any part of the compressed gas medical air cylinder or the associated equipment used to deliver the gas to the patient.
Cylinders must be kept out of reach of children.
Cylinders must not be exposed to extremes of temperature. Always ensure hands are clean and free from any oils or grease.
See Section 4.2 Dose and Method of Administration, Handling and instructions for use; Section 6.4 Special Precautions for Storage.
Additional information is contained in the safety data sheet from the sponsor. Oxygen toxicity may occur with prolonged exposure to high inspired oxygen levels. High oxygen concentrations should be given for the shortest possible time required to achieve the required clinical outcome, and reduced as soon as possible to the lowest concentrations needed to prevent or treat hypoxia.
There is evidence in the literature that the risk of oxygen toxicity can be minimised if the treatment follows these guidelines (oxygen fraction in the inhaled air/gas mixture = FiO₂):
Oxygen in concentrations up to 100% (FiO₂ 1.0) should not be given for more than 6 hours.
Oxygen in concentrations above 60-70% (FiO₂ 0.6-0.7) should not be given for more than 24 hours.
Oxygen in concentrations above 40-50% (FiO₂ 0.4-0.5) should not be given during the next 24 hours.
Oxygen concentrations > 40% (FiO₂ > 0.4) can potentially cause damage after 2 days.
Premature infants are excluded from these guidelines because retrolental fibroplasia may occur with a much lower FiO₂.
The response to oxygen varies depending on the underlying disorder, cause of hypoxia, and clinical status of the individual patient. The clinician should consider all relevant factors in selecting the inspired oxygen concentration, flow rate, and duration of therapy. Careful monitoring of oxygen therapy is required, with repeated clinical assessment and monitoring of inhaled oxygen concentration (FiO₂) and checks of arterial oxygenation e.g. by arterial blood gas measurements, or arterial oxygen saturations via pulse oximetry, as clinically appropriate.

Use in the elderly.

Use in the elderly is determined by clinical assessment and course of the illness. Some elderly patients with chronic severe obstructive airways disease may rely on hypoxic drive for respiration and require relatively low inspired oxygen concentrations: see Section 4.2 Dose and Method of Administration.

Paediatric use.

Special care must be observed when administering oxygen to neonates. Preterm infants are more susceptible to the direct and indirect potentially toxic effects of oxygen exposure, including retinopathy of prematurity. Clinical protocols appropriate to the condition and age of the infant should be followed, including advice for appropriate arterial oxygen saturation monitoring. Ongoing monitoring is required to achieve the targeted arterial saturation using the lowest possible inspired oxygen levels.

Effects on laboratory tests.

None stated.

4.5 Interactions with Other Medicines and Other Forms of Interactions

Bleomycin.

Potentially fatal pulmonary toxicity can develop in patients treated with bleomycin who are exposed to conventional oxygen concentrations during anaesthesia. It is recommended that oxygen concentration in bleomycin-treated patients should where possible be limited to less than 30% (FiO₂ < 0.3), with use of low concentrations (25%, FiO₂ 0.25) during surgery and postoperative recovery, and avoidance of pulmonary interstitial oedema by careful choice and monitoring of fluid replacement (see bleomycin product information).

Amiodarone.

High dose oxygen may increase the risks of amiodarone-induced post-operative adult respiratory distress syndrome (see amiodarone product information).

4.6 Fertility, Pregnancy and Lactation

Effects on fertility.

Medical oxygen has not been shown to adversely affect fertility when used as clinically required.
(Category A)
When oxygen is used in pregnancy as clinically required, to treat intercurrent illness and avoid hypoxia, at the lowest concentration for the shortest possible time.
Hyperbaric oxygen treatment during gestation in mice, rats, hamsters and rabbits led to increased resorptions and foetal abnormalities, and decreased foetal body weights.
Category A does not relate to hyperbaric oxygen treatment and specialist literature should be consulted.
Oxygen is used during breast-feeding as clinically required, to treat intercurrent illness and avoid hypoxia, at the lowest concentration for the shortest possible time.

4.7 Effects on Ability to Drive and Use Machines

Under normal conditions, oxygen does not interfere with consciousness; however patients who require oxygen support will require individual assessment as to their ability to drive or to operate machinery. Oxygen therapy may affect the level of consciousness in a patient with hypercapnia and reduced respiratory drive. (See Section 4.8 Adverse Effects (Undesirable Effects)).

4.8 Adverse Effects (Undesirable Effects)

Oxygen toxicity depends upon both the inspired partial pressure of oxygen (a function of concentration and barometric pressure) and duration of exposure, the safe duration decreasing as pressure increases.
With 100% normobaric oxygen, symptoms of pulmonary toxicity are cough, substernal chest pain, mild dyspnoea, malaise, nausea, or transient paraesthesia after 6-24 hours, substernal distress, atelectasis, decrease in vital capacity (after 18 hours) and acute respiratory distress syndrome (after 24-48 hours).
Up to 2 atmospheres, pulmonary toxicity occurs before central nervous system toxicity (CNS); at higher pressures, the reverse applies. Symptoms of CNS toxicity include nausea, mood changes, vertigo, twitching, convulsions and loss of consciousness.
Adverse effects of oxygen exposure as described in standard texts include:

Blood and lymphatic system disorders.

Haemolysis of red blood cells.

Ear and labyrinth disorders.

Mucosal dryness and irritation, ear or sinus trauma, tympanic membrane rupture with hyperbaric oxygen.

Eye disorders.

Retinopathy of prematurity, retrolental fibroplasia in neonates; tunnel vision; myopia with hyperbaric oxygen.

Gastrointestinal disorders.

Nausea.

General disorders and administration site conditions.

Lipid peroxidation and cell membrane damage due to chemical toxicity in any metabolising cells.

Nervous system disorders.

Drowsiness/carbon dioxide narcosis if given in high concentrations to patients with reduced sensitivity to carbon dioxide tension in arterial blood; effects of hyperbaric oxygen toxicity include vertigo, convulsions, loss of consciousness.

Respiratory thoracic and mediastinal disorders.

Chest tightness, dry cough, pain on inspiration; decreased vital capacity; pneumonitis; atelectasis; bronchopulmonary dysplasia in neonates; carbon dioxide retention when given in high concentrations to patients with reduced sensitivity to arterial CO₂ tension; pneumothorax or air embolism have been reported with hyperbaric oxygen.

Reporting suspected adverse effects.

Reporting suspected adverse reactions after registration of the medicinal product is important. It allows continued monitoring of the benefit-risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions at www.tga.gov.au/reporting-problems.

4.9 Overdose

In oxygen intoxication there may be pulmonary symptoms of chest tightness, dry cough, and pain on inspiration. Care must be taken where symptoms cannot present (e.g. intensive care) since the onset of objective evidence for pulmonary oxygen toxicity occurs late in its development (see Section 4.8 Adverse Effects (Undesirable Effects)).
The oxygen therapy should be reduced or, if possible, stopped, and symptomatic treatment should be started in order to maintain vital functions (e.g. artificial ventilation/assisted ventilation should be given if the patient shows signs of failing respiration).
For information on the management of overdose, contact the Poisons Information Centre on 131126 (Australia).

5 Pharmacological Properties

Pharmacotherapeutic group: GASMED, gas, medical. ATC code: V03AN01.

5.1 Pharmacodynamic Properties

Mechanism of action.

Oxygen is present in the atmosphere at 21% and is essential for cellular metabolism. The therapeutic use of oxygen is intended to improve, or prevent a reduction in, the oxygen content of blood leaving the lungs (or the oxygenator of a heart-lung machine).
The basal oxygen consumption in humans is approximately 250 mL/min for a body surface of 1.8 square metres. In anaesthesia and natural sleep it is reduced by about 10% and decreased by about 50% for a 10°C fall in body temperature.
Alveolar air contains about 14% oxygen at 14 kPa (105 mmHg) and the arterial blood has an oxygen tension of 13 kPa (97 mmHg). The difference (the alveolar-arterial oxygen tension gradient), increases with age, and may be as great as 4 kPa (30 mmHg) in a healthy, elderly individual.
Oxygen in the blood is mostly combined with haemoglobin. Normally haemoglobin in arterial blood is 97% saturated and the oxygen content of the blood is 19.8 vol %, 0.3 mL of this being carried in solution. The remainder is bound to haemoglobin.
The concept of "oxygen availability" can be used to quantify the amount available to the body. It can be expressed as product of cardiac output and the oxygen content of the blood. This is estimated by (cardiac output) x (Hb concentration) x (amount of oxygen carried by one gram of haemoglobin) x (% saturation of haemoglobin), plus the amount in solution.
The average healthy individual with basal oxygen consumption has no more than 4 minutes supply of oxygen circulating in the blood.

5.2 Pharmacokinetic Properties

Absorption.

Inhaled oxygen is transported via the airways to the lung with the inspired air. Oxygen is absorbed in the alveoli by gas exchange resulting from the difference in partial pressure from the inspired air/gas mixture to the capillary blood. Increasing the inhaled oxygen concentration (i.e. inspired gas oxygen fraction, FiO₂), is intended to compensate for problems of ventilation, diffusion and ventilation/perfusion mismatch, by increasing the alveolar partial pressure of oxygen.

Distribution.

The uptake of oxygen by the blood in the lungs and discharge to the tissues is determined by the oxygen dissociation curve.
The characteristic sigmoid curve ensures that, at tensions between 5 kPa (40 mmHg) and 2 kPa (15 mmHg), the oxygen carried in the blood from the lungs can be readily given up to the tissues. See Figure 1.

At rest, mixed venous blood returning to the lungs contains 13-14 mL of oxygen per 100 mL, but with severe exercise, the oxygen content may fall to 3-4 mL. In very active tissue, there is almost complete extraction.

5.3 Preclinical Safety Data

Genotoxicity.

Genotoxicity studies (in vitro and in vivo) have shown that hyperbaric oxygen causes DNA damage and chromosomal aberrations. However, the risk of damage to genetic material from intermittent exposures to normobaric oxygen is considered to be low.

Carcinogenicity.

There are no carcinogenicity studies with oxygen, but carcinogenic risk from intermittent exposures to normobaric oxygen is likely to be low.

6 Pharmaceutical Particulars

6.1 List of Excipients

Not applicable.

6.2 Incompatibilities

Incompatibilities were either not assessed or not identified as part of the registration of this medicine.

6.3 Shelf Life

In Australia, information on the shelf life can be found on the public summary of the Australian Register of Therapeutic Goods (ARTG). The expiry date can be found on the packaging.

6.4 Special Precautions for Storage

Store below 30 degrees Celsius.
The normal precautions required in the storage and use of medical gas cylinders are applicable. See Section 4.4 Special Warnings and Precautions for Use.

6.5 Nature and Contents of Container

Aluminium alloy (C or CR wound with carbon fibre) or steel (D, E and G) gas cylinder with brass valve closure. The BR, CR, CSR, CXR, DR and ER gas cylinders are supplied with either pin index or integrated analogue regulator valve closures.

Pack sizes.

See Table 1.

6.6 Special Precautions for Disposal

Empty cylinders are immediately returned to the empty cylinder store for return to the supplier.

6.7 Physicochemical Properties

Aeris compressed medical gas 100% v/v oxygen E.P. grade complies with current European Pharmacopoeial specifications:
Purity: not less than 99.5% v/v.
Carbon dioxide: not more than 300 ppm v/v.
Carbon monoxide: not more than 5 ppm v/v.
Water: not more than 67 ppm v/v.
Appearance: odourless, colourless gas.
Vapour density: 1.105 at 25°C.
Boiling point: -183°C.
Combustion characteristics: non-flammable. Strongly supports combustion.

Chemical structure.

Molecular formula: O₂.

CAS number.

7782-44-7.

7 Medicine Schedule (Poisons Standard)

Unscheduled.

Service Unavailable

Consumer medicine information

Aeris Medical E.P. Grade Compressed Oxygen

Oxygen

Keep track of your medicines

BRAND INFORMATION